Annette D De Kloet

Annette D De Kloet,

Assistant Professor

Department: MD-PHYSIOLOGY FUNCTIONAL GENOM
Business Phone: (850) 212-6209
Business Email: adekloet@ufl.edu

Teaching Profile

Courses Taught
2020-2021
PAS5025 Human Physiology
2019-2020
GMS6473 Fundamentals of Physiology and Functional Genomics III
2019-2020
GMS6472 Fundamentals of Physiology and Functional Genomics II
2018
GMS6400C Principles of Physiology
2018,2021
GMS6405 Fundamentals of Endocrine Physiology

Publications

2022
A Novel Organ-Specific Approach to Selectively Target Sensory Afferents Innervating the Aortic Arch.
Frontiers in physiology. 13 [DOI] 10.3389/fphys.2022.841078. [PMID] 35399269.
2022
Conditioned social preference and reward value of activating oxytocin-receptor-expressing ventral tegmental area neurons following repeated daily binge ethanol intake.
Alcoholism, clinical and experimental research. 46(2):194-206 [DOI] 10.1111/acer.14769. [PMID] 34964139.
2022
Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia-induced pulmonary hypertension.
Pulmonary circulation. 12(1) [DOI] 10.1002/pul2.12015. [PMID] 35506083.
2022
Oxytocin and cardiometabolic interoception: Knowing oneself affects ingestive and social behaviors.
Appetite. 175 [DOI] 10.1016/j.appet.2022.106054. [PMID] 35447163.
2022
Targeting angiotensin type-2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice.
Cardiovascular research. 118(3):883-896 [DOI] 10.1093/cvr/cvab085. [PMID] 33723600.
2021
An Angiotensin-Responsive Connection from the Lamina Terminalis to the Paraventricular Nucleus of the Hypothalamus Evokes Vasopressin Secretion to Increase Blood Pressure in Mice.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(7):1429-1442 [DOI] 10.1523/JNEUROSCI.1600-20.2020. [PMID] 33328294.
2021
Central and peripheral GLP-1 systems independently suppress eating.
Nature metabolism. 3(2):258-273 [DOI] 10.1038/s42255-021-00344-4. [PMID] 33589843.
2021
Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 41(21):4641-4657 [DOI] 10.1523/JNEUROSCI.0251-21.2021. [PMID] 33858944.
2020
Brain Angiotensin Type-1 and Type-2 Receptors in Physiological and Hypertensive Conditions: Focus on Neuroinflammation.
Current hypertension reports. 22(7) [DOI] 10.1007/s11906-020-01062-0. [PMID] 32661792.
2020
Brain angiotensin type-1 and type-2 receptors: cellular locations under normal and hypertensive conditions.
Hypertension research : official journal of the Japanese Society of Hypertension. 43(4):281-295 [DOI] 10.1038/s41440-019-0374-8. [PMID] 31853042.
2020
Endogenous oxytocin inhibits hypothalamic corticotrophin-releasing hormone neurones following acute hypernatraemia.
Journal of neuroendocrinology. 32(3) [DOI] 10.1111/jne.12839. [PMID] 32133707.
2020
Gut Pathology and Its Rescue by ACE2 (Angiotensin-Converting Enzyme 2) in Hypoxia-Induced Pulmonary Hypertension.
Hypertension (Dallas, Tex. : 1979). 76(1):206-216 [DOI] 10.1161/HYPERTENSIONAHA.120.14931. [PMID] 32418496.
2020
Overexpression of angiotensin converting enzyme 2 reduces anxiety-like behavior in female mice.
Physiology & behavior. 224 [DOI] 10.1016/j.physbeh.2020.113002. [PMID] 32525008.
2019
An anti-CRF antibody suppresses the HPA axis and reverses stress-induced phenotypes.
The Journal of experimental medicine. 216(11):2479-2491 [DOI] 10.1084/jem.20190430. [PMID] 31467037.
2019
Angiotensin receptor expression revealed by reporter mice and beneficial effects of AT2R agonist in retinal cells.
Experimental eye research. 187 [DOI] 10.1016/j.exer.2019.107770. [PMID] 31449794.
2019
Oxytocin Receptors Are Expressed by Glutamatergic Prefrontal Cortical Neurons That Selectively Modulate Social Recognition.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(17):3249-3263 [DOI] 10.1523/JNEUROSCI.2944-18.2019. [PMID] 30804095.
2019
Top-down and bottom-up control of stress-coping.
Journal of neuroendocrinology. 31(3) [DOI] 10.1111/jne.12675. [PMID] 30578574.
2018
Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(32):7032-7057 [DOI] 10.1523/JNEUROSCI.3542-17.2018. [PMID] 29976627.
2018
Coupling corticotropin-releasing-hormone and angiotensin converting enzyme 2 dampens stress responsiveness in male mice.
Neuropharmacology. 133:85-93 [DOI] 10.1016/j.neuropharm.2018.01.025. [PMID] 29360543.
2018
Fat-brain connections: Adipocyte glucocorticoid control of stress and metabolism.
Frontiers in neuroendocrinology. 48:50-57 [DOI] 10.1016/j.yfrne.2017.10.005. [PMID] 29042142.
2018
Macrophage angiotensin II type 2 receptor triggers neuropathic pain.
Proceedings of the National Academy of Sciences of the United States of America. 115(34):E8057-E8066 [DOI] 10.1073/pnas.1721815115. [PMID] 30082378.
2018
New horizons for future research – Critical issues to consider for maximizing research excellence and impact.
Molecular metabolism. 14:53-59 [DOI] 10.1016/j.molmet.2018.05.007. [PMID] 29886182.
2017
A Single Angiotensin II Hypertensive Stimulus Is Associated with Prolonged Neuronal and Immune System Activation in Wistar-Kyoto Rats.
Frontiers in physiology. 8 [DOI] 10.3389/fphys.2017.00592. [PMID] 28912720.
2017
A Unique “Angiotensin-Sensitive” Neuronal Population Coordinates Neuroendocrine, Cardiovascular, and Behavioral Responses to Stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 37(13):3478-3490 [DOI] 10.1523/JNEUROSCI.3674-16.2017. [PMID] 28219987.
2017
Oxytocin receptors are expressed on dopamine and glutamate neurons in the mouse ventral tegmental area that project to nucleus accumbens and other mesolimbic targets.
The Journal of comparative neurology. 525(5):1094-1108 [DOI] 10.1002/cne.24116. [PMID] 27615433.
2017
Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats.
PloS one. 12(7) [DOI] 10.1371/journal.pone.0180738. [PMID] 28671997.
2017
Protective Angiotensin Type 2 Receptors in the Brain and Hypertension.
Current hypertension reports. 19(6) [DOI] 10.1007/s11906-017-0746-x. [PMID] 28488048.
2017
Susceptibility or resilience? Prenatal stress predisposes male rats to social subordination, but facilitates adaptation to subordinate status.
Physiology & behavior. 178:117-125 [DOI] 10.1016/j.physbeh.2017.03.006. [PMID] 28284881.
2017
The intricacies of the renin-angiotensin-system in metabolic regulation.
Physiology & behavior. 178:157-165 [DOI] 10.1016/j.physbeh.2016.11.020. [PMID] 27887998.
2016
Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus control cardiovascular reactivity and anxiety-like behavior in male mice.
Physiological genomics. 48(9):667-76 [DOI] 10.1152/physiolgenomics.00029.2016. [PMID] 27468749.
2016
Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice.
Endocrinology. 157(8):3167-80 [DOI] 10.1210/en.2016-1131. [PMID] 27267713.
2016
Cross talk between AT1 receptors and Toll-like receptor 4 in microglia contributes to angiotensin II-derived ROS production in the hypothalamic paraventricular nucleus.
American journal of physiology. Heart and circulatory physiology. 310(3):H404-15 [DOI] 10.1152/ajpheart.00247.2015. [PMID] 26637556.
2016
Increasing brain angiotensin converting enzyme 2 activity decreases anxiety-like behavior in male mice by activating central Mas receptors.
Neuropharmacology. 105:114-123 [DOI] 10.1016/j.neuropharm.2015.12.026. [PMID] 26767952.
2016
Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system.
Brain structure & function. 221(2):891-912 [DOI] 10.1007/s00429-014-0943-1. [PMID] 25427952.
2015
Adipocyte glucocorticoid receptors mediate fat-to-brain signaling.
Psychoneuroendocrinology. 56:110-9 [DOI] 10.1016/j.psyneuen.2015.03.008. [PMID] 25808702.
2015
Angiotensin type 2 receptors: blood pressure regulation and end organ damage.
Current opinion in pharmacology. 21:115-21 [DOI] 10.1016/j.coph.2015.01.004. [PMID] 25677800.
2015
Hydration and beyond: neuropeptides as mediators of hydromineral balance, anxiety and stress-responsiveness.
Frontiers in systems neuroscience. 9 [DOI] 10.3389/fnsys.2015.00046. [PMID] 25873866.
2015
Neuroendocrine Function After Hypothalamic Depletion of Glucocorticoid Receptors in Male and Female Mice.
Endocrinology. 156(8):2843-53 [DOI] 10.1210/en.2015-1276. [PMID] 26046806.
2015
Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control.
American journal of physiology. Regulatory, integrative and comparative physiology. 309(5):R444-58 [DOI] 10.1152/ajpregu.00078.2015. [PMID] 26084692.
2014
Acute hypernatremia promotes anxiolysis and attenuates stress-induced activation of the hypothalamic-pituitary-adrenal axis in male mice.
Physiology & behavior. 136:91-6 [DOI] 10.1016/j.physbeh.2014.03.027. [PMID] 24704193.
2014
Obesity induces neuroinflammation mediated by altered expression of the renin-angiotensin system in mouse forebrain nuclei.
Physiology & behavior. 136:31-8 [DOI] 10.1016/j.physbeh.2014.01.016. [PMID] 24508821.
2013
Acute hypernatremia exerts an inhibitory oxytocinergic tone that is associated with anxiolytic mood in male rats.
Endocrinology. 154(7):2457-67 [DOI] 10.1210/en.2013-1049. [PMID] 23653461.
2013
Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 33(11):4825-33 [DOI] 10.1523/JNEUROSCI.3806-12.2013. [PMID] 23486953.
2013
Neuroimmune communication in hypertension and obesity: a new therapeutic angle?
Pharmacology & therapeutics. 138(3):428-40 [DOI] 10.1016/j.pharmthera.2013.02.005. [PMID] 23458610.
2013
Subcutaneous Adipose Tissue Transplantation in Diet-Induced Obese Mice Attenuates Metabolic Dysregulation While Removal Exacerbates It.
Physiological reports. 1(2) [PMID] 23914298.
2012
Female rats are relatively more sensitive to reduced lipid versus reduced carbohydrate availability.
Nutrition & diabetes. 2 [DOI] 10.1038/nutd.2011.23. [PMID] 23169552.
2011
Blood-borne angiotensin II acts in the brain to influence behavioral and endocrine responses to psychogenic stress.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(42):15009-15 [DOI] 10.1523/JNEUROSCI.0892-11.2011. [PMID] 22016534.
2011
Central angiotensin II has catabolic action at white and brown adipose tissue.
American journal of physiology. Endocrinology and metabolism. 301(6):E1081-91 [DOI] 10.1152/ajpendo.00307.2011. [PMID] 21862725.
2011
Hydration state controls stress responsiveness and social behavior.
The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(14):5470-6 [DOI] 10.1523/JNEUROSCI.6078-10.2011. [PMID] 21471383.
2011
The effect of TNF╬▒ on food intake and central insulin sensitivity in rats.
Physiology & behavior. 103(1):17-20 [DOI] 10.1016/j.physbeh.2010.11.037. [PMID] 21163282.
2010
Introduction – obesity and food intake: basic and clinical approaches.
Forum of nutrition. 63:1-8 [DOI] 10.1159/000264391. [PMID] 19955771.
2010
Molecular neuroendocrine targets for obesity therapy.
Current opinion in endocrinology, diabetes, and obesity. 17(5):441-5 [DOI] 10.1097/MED.0b013e32833c3013. [PMID] 20585249.
2010
Pleasurable behaviors reduce stress via brain reward pathways.
Proceedings of the National Academy of Sciences of the United States of America. 107(47):20529-34 [DOI] 10.1073/pnas.1007740107. [PMID] 21059919.
2010
Post-ingestive signals and satiation of water and sodium intake of male rats.
Physiology & behavior. 99(5):657-62 [DOI] 10.1016/j.physbeh.2010.01.030. [PMID] 20138075.
2010
The renin angiotensin system and the metabolic syndrome.
Physiology & behavior. 100(5):525-34 [DOI] 10.1016/j.physbeh.2010.03.018. [PMID] 20381510.
2009
Minireview: Endocannabinoids and their receptors as targets for obesity therapy.
Endocrinology. 150(6):2531-6 [DOI] 10.1210/en.2009-0046. [PMID] 19372200.
2009
The effect of angiotensin-converting enzyme inhibition using captopril on energy balance and glucose homeostasis.
Endocrinology. 150(9):4114-23 [DOI] 10.1210/en.2009-0065. [PMID] 19497971.
2008
Angiotensin type 1 receptors in the subfornical organ mediate the drinking and hypothalamic-pituitary-adrenal response to systemic isoproterenol.
Endocrinology. 149(12):6416-24 [DOI] 10.1210/en.2008-0477. [PMID] 18687780.

Grants

Jan 2021 ACTIVE
Gustatory and interoceptive regulation of hypertension
Role: Other
Funding: NATL INST OF HLTH NHLBI
Feb 2020 ACTIVE
Interrogating stress-relieving neural circuits to alleviate cardiovascular disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jan 2019 ACTIVE
Interrogating distinct angiotensin type-1 and type-2 receptor containing brain circuits to understand and alleviate hypertension
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Dec 2017 ACTIVE
Neurons expressing angiotensin type 2 receptors in the NTS as an access point for cardiovascular control.
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Dec 2017 – Jan 2020
Targeting brain angiotensin signaling to discern and alleviate stress-related disease.
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2017 – Jun 2019
Targeting angiotensin-vasopressin interactions in the brain to alleviate hypertension
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Sep 2016 – Aug 2020
Novel role of central AT2R in blood pressure regulation
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI

Contact Details

Phones:
Business:
(850) 212-6209
Emails:
Business:
adekloet@ufl.edu
Addresses:
Business Mailing:
1149 NEWELL DR RM L4 162 BLDG 59
GAINESVILLE FL 32610