- Indirect calorimetry (TSE Phenomaster)
- Telemetric recording of cardiovascular parameters, body temperature, and plasma glucose (DSI and TSE Stellar Systems)
- Whole body composition analysis via Bruker NMR
- Optogenetics, laser light sources and fiber optic hardware (Doric Instruments)
- In vivo Calcium Imaging (Inscopix)
- Glomerular filtration rate (MediBeacon)
- Blood and urine electrolyte analysis
- Gene expression profiling
- Histological processing
- Light and confocal microscopy
- Radioimmunoassays for plasma hormones
CICMD Research Support
Available Expertise & Technical Support
- Blood pressure monitoring in various mouse models (e.g., AT2 reporter mice, PER1KO mice, Cre+/Cre– lines).
- Ventricular pressure measurements, including right ventricular systolic pressure (RVSP) and left ventricular pressure.
- Myography experiments to evaluate vascular function in aortic tissues (e.g., AATKO and control mice).
- Microsurgical procedures, including osmotic mini-pump implantation for AngII infusion models.
- Pharmacologic testing to assess cardiovascular effects of novel compounds (e.g., CaV2.2 inhibitor C2230).
Examples of Past Collaborative Projects
- Recording blood pressure in AT2 reporter mice.
- Conducting aortic myography in AATKO mice .
- Measuring RVSP and LV pressure and training lab members.
- Performing osmotic pump surgeries and blood pressure assessments.
- Blood pressure measurements in Cre– and Cre+ mice.
- Evaluating cardiovascular responses to C2230.
Service Strengths
- Advanced technical skillset in cardiovascular physiology and microsurgical techniques.
- Reliable, reproducible experimental execution across models.
- Cross-disciplinary collaboration with CICMD labs.
- Training and mentorship to expand research capacity.
- Direct contributions to peer-reviewed publications.