William T Donahoo, MD, FTOS
CHIEF & CLIN PROF
About William T Donahoo
William “Troy” Donahoo, MD, FTOS, is a Clinical Professor and Chief of the Division of Endocrinology, Diabetes & Metabolism at the University of Florida. He received his medical degree from the University of Colorado, where he also continued his training through an internship and residency in internal medicine. He then completed a clinical fellowship in endocrinology, metabolism and diabetes, as well as a research fellowship in the same area. He is a practicing Endocrinologist and diabetes and obesity medicine researcher with research experience in lifestyle interventions, physiological studies and big data epidemiology/comparative effectiveness research. Since 2010, his major research focus has been leveraging data from the electronic medical record to answer epidemiological and pragmatic outcomes questions. In high impact work, he showed a substantial risk of increased opioid use following bariatric surgery. He has also been able to develop and validate algorithms for type 1 and type 2 diabetes in adults and to use Natural Language Processing to determine provision of weight management counseling following delivery in women with a history of gestational diabetes. At UF, he has used the UF IDR and the OneFlorida+ clinical research network to develop a computable phenotype for type 1 vs type 2 diabetes in children and adolescents and helped to develop and validate a computable phenotype for type 2 diabetes in the PCORNet. He is currently working on prediction modeling and clinical decision support tools and recently published a study using machine learning to diagnose hepatic steatosis and fibrosis.
Teaching Profile
Courses Taught
2018
GMS7980 Research for Doctoral Dissertation
Board Certifications
-
Endocrinology, Diabetes and MetabolismAmerican Board of Internal Medicine
-
Internal MedicineAmerican Board of Internal Medicine
Clinical Profile
Specialties
- Endocrinology, Diabetes and Metabolism
- Endocrinology, Diabetes and Metabolism
Areas of Interest
- Bariatric Surgery
- Diabetes
- Obesity
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-2126-860X
Publications
2023
Assessment of the Risk Evaluation and Mitigation Strategy (REMS) for Phentermine–Topiramate to Prevent Exposure During Pregnancy
Annals of Internal Medicine.
176(4):443-454
[DOI] 10.7326/m22-1743.
2023
Association of Medication Adherence With HbA1c Control Among American Indian Adults With Type 2 Diabetes Using Tribal Health Services.
Diabetes care.
46(6):1245-1251
[DOI] 10.2337/dc22-1885.
[PMID] 37068266.
2023
Impact of Contextual-Level Social Determinants of Health on Newer Antidiabetic Drug Adoption in Patients with Type 2 Diabetes
International Journal of Environmental Research and Public Health.
20(5)
[DOI] 10.3390/ijerph20054036.
[PMID] 36901047.
2023
Newer glucose-lowering drugs and risk of dementia: A systematic review and meta-analysis of observational studies.
Journal of the American Geriatrics Society.
[DOI] 10.1111/jgs.18306.
[PMID] 36821780.
2022
Medication Adherence and Cardiometabolic Control Indicators Among American Indian Adults Receiving Tribal Health Services: Protocol for a Longitudinal Electronic Health Records Study
JMIR Research Protocols.
11(10)
[DOI] 10.2196/39193.
[PMID] 36279173.
2022
Noninvasive Diagnosis of Nonalcoholic Steatohepatitis and Advanced Liver Fibrosis Using Machine Learning Methods: Comparative Study With Existing Quantitative Risk Scores
JMIR Medical Informatics.
10(6)
[DOI] 10.2196/36997.
[PMID] 35666557.
2022
Topiramate Utilization After Phentermine/Topiramate Approval for Obesity Management: Risk Minimization in the Era of Drug Repurposing.
Drug safety.
45(12):1517-1527
[DOI] 10.1007/s40264-022-01244-6.
[PMID] 36318419.
2021
Comparing cardiovascular benefits between GLP-1 receptor agonists and SGLT2 inhibitors as an add-on to metformin among patients with type 2 diabetes: A retrospective cohort study.
Journal of diabetes and its complications.
35(9)
[DOI] 10.1016/j.jdiacomp.2021.107972.
[PMID] 34247911.
2021
COVID-19 vaccines are effective in people with obesity: A position statement from The Obesity Society.
Obesity (Silver Spring, Md.).
29(10):1575-1579
[DOI] 10.1002/oby.23251.
[PMID] 34212511.
2021
Dietary supplements and alternative therapies for obesity: A Perspective from The Obesity Society’s Clinical Committee.
Obesity (Silver Spring, Md.).
29(7):1095-1098
[DOI] 10.1002/oby.23189.
[PMID] 34159756.
2020
Acceptance-based therapy: the potential to augment behavioral interventions in the treatment of type 2 diabetes.
Nutrition & diabetes.
10(1)
[DOI] 10.1038/s41387-020-0106-9.
[PMID] 32066659.
2020
An Iterative Process for Identifying Pediatric Patients With Type 1 Diabetes: Retrospective Observational Study
JMIR Medical Informatics.
8(9)
[DOI] 10.2196/18874.
[PMID] 32886067.
2020
Determinants of Adherence in Time-Restricted Feeding in Older Adults: Lessons from a Pilot Study.
Nutrients.
12(3)
[DOI] 10.3390/nu12030874.
[PMID] 32213965.
2020
Diabetes medication regimens and patient clinical characteristics in the national patient-centered clinical research network, PCORnet.
Pharmacology research & perspectives.
8(5)
[DOI] 10.1002/prp2.637.
[PMID] 32881317.
2020
How to Manage a Patient with Weight Regain.
American family physician.
102(9):567-570
[PMID] 33118796.
2019
Neurocognitive Deficits in a Cohort With Class 2 and Class 3 Obesity: Contributions of Type 2 Diabetes and Other Comorbidities.
Obesity (Silver Spring, Md.).
27(7):1099-1106
[DOI] 10.1002/oby.22508.
[PMID] 31116012.
2019
Objectively measured pediatric obesity prevalence using the OneFlorida Clinical Research Consortium.
Obesity research & clinical practice.
13(1):12-15
[DOI] 10.1016/j.orcp.2018.10.002.
[PMID] 30391132.
2019
Performance of a computable phenotype for identification of patients with diabetes within PCORnet: The Patient-Centered Clinical Research Network.
Pharmacoepidemiology and drug safety.
28(5):632-639
[DOI] 10.1002/pds.4718.
[PMID] 30680840.
2019
The Effects of Time Restricted Feeding on Overweight, Older Adults: A Pilot Study.
Nutrients.
11(7)
[DOI] 10.3390/nu11071500.
[PMID] 31262054.
2018
Evidence of a gap in understanding obesity among physicians.
Obesity science & practice.
4(1):46-51
[DOI] 10.1002/osp4.146.
[PMID] 29479464.
2018
Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.
Obesity (Silver Spring, Md.).
26(2):254-268
[DOI] 10.1002/oby.22065.
[PMID] 29086496.
2018
Marijuana’s Influence on Pain Scores, Initial Weight Loss, and Other Bariatric Surgical Outcomes.
The Permanente journal.
22:18-002
[DOI] 10.7812/TPP/18-002.
[PMID] 30010532.
2016
Investing in Obesity Treatment: Kaiser Permanente’s Approach to Chronic Disease Management.
Current obesity reports.
5(3):307-11
[DOI] 10.1007/s13679-016-0223-x.
[PMID] 27342446.
2016
Women With Gestational Diabetes Mellitus Randomized to a Higher-Complex Carbohydrate/Low-Fat Diet Manifest Lower Adipose Tissue Insulin Resistance, Inflammation, Glucose, and Free Fatty Acids: A Pilot Study.
Diabetes care.
39(1):39-42
[DOI] 10.2337/dc15-0515.
[PMID] 26223240.
2015
Evaluation of care management intensity and bariatric surgical weight loss.
The American journal of managed care.
21(3):182-9
[PMID] 25880623.
2014
A higher-complex carbohydrate diet in gestational diabetes mellitus achieves glucose targets and lowers postprandial lipids: a randomized crossover study.
Diabetes care.
37(5):1254-62
[DOI] 10.2337/dc13-2411.
[PMID] 24595632.
2014
Automating assessment of lifestyle counseling in electronic health records.
American journal of preventive medicine.
46(5):457-64
[DOI] 10.1016/j.amepre.2014.01.001.
[PMID] 24745635.
2014
Chronic opioid use emerging after bariatric surgery.
Pharmacoepidemiology and drug safety.
23(12):1247-57
[DOI] 10.1002/pds.3625.
[PMID] 24733580.
2014
Comparative effectiveness of laparoscopic adjustable gastric banding vs laparoscopic gastric bypass.
JAMA surgery.
149(12):1279-87
[DOI] 10.1001/jamasurg.2014.1674.
[PMID] 25353723.
2013
Chronic use of opioid medications before and after bariatric surgery.
JAMA.
310(13):1369-76
[DOI] 10.1001/jama.2013.278344.
[PMID] 24084922.
2011
Leptin increases skeletal muscle lipoprotein lipase and postprandial lipid metabolism in mice.
Metabolism: clinical and experimental.
60(3):438-43
[DOI] 10.1016/j.metabol.2010.03.016.
[PMID] 20494377.
2009
Greater systemic lipolysis in women compared with men during moderate-dose infusion of epinephrine and/or norepinephrine.
Journal of applied physiology (Bethesda, Md. : 1985).
107(1):200-10
[DOI] 10.1152/japplphysiol.90812.2008.
[PMID] 19407251.
2009
Plasma alpha-melanocyte-stimulating hormone: sex differences and correlations with obesity.
Metabolism: clinical and experimental.
58(1):16-21
[DOI] 10.1016/j.metabol.2008.07.028.
[PMID] 19059526.
2009
The relationship between dietary fat and fatty acid intake and body weight, diabetes, and the metabolic syndrome.
Annals of nutrition & metabolism.
55(1-3):229-43
[DOI] 10.1159/000229004.
[PMID] 19752544.
2008
Dietary fat increases energy intake across the range of typical consumption in the United States.
Obesity (Silver Spring, Md.).
16(1):64-9
[DOI] 10.1038/oby.2007.31.
[PMID] 18223614.
2007
Changes in 24-h substrate oxidation in older and younger men in response to exercise.
Journal of applied physiology (Bethesda, Md. : 1985).
103(5):1576-82
[PMID] 17717111.
2006
Acute and 1-month effect of small-volume suction lipectomy on insulin sensitivity and cardiovascular risk.
International journal of obesity (2005).
30(8):1217-22
[PMID] 16520815.
2006
Glucose kinetics differ between women and men, during and after exercise.
Journal of applied physiology (Bethesda, Md. : 1985).
100(6):1883-94
[PMID] 16714415.
2005
Effect of low- and high-calcium dairy-based diets on macronutrient oxidation in humans.
Obesity research.
13(12):2102-12
[PMID] 16421344.
2005
Insulin sensitivity determines the effectiveness of dietary macronutrient composition on weight loss in obese women.
Obesity research.
13(4):703-9
[PMID] 15897479.
2005
QT interval dispersion and resting metabolic rate in chronic anorexia nervosa.
The International journal of eating disorders.
37(2):166-70
[PMID] 15732074.
2005
The paradox of normal serum albumin in anorexia nervosa: a case report.
The International journal of eating disorders.
37(3):278-80
[PMID] 15822081.
2005
Twenty-four-hour metabolic responses to resistance exercise in women.
Journal of strength and conditioning research.
19(1):61-6
[PMID] 15705046.
2004
Commercially available pedometers: considerations for accurate step counting.
Preventive medicine.
39(2):361-8
[PMID] 15226047.
2004
Enhanced metabolic efficiency contributes to weight regain after weight loss in obesity-prone rats.
American journal of physiology. Regulatory, integrative and comparative physiology.
287(6):R1306-15
[PMID] 15331386.
2004
Physiological mechanisms for the seasonal changes in serum cholesterol level.
Archives of internal medicine.
164(22):2506; author reply 2506-7
[PMID] 15596654.
2004
Resistant starch consumption promotes lipid oxidation.
Nutrition & metabolism.
1(1)
[PMID] 15507129.
2004
Resting and ambulatory heart rate variability in chronic anorexia nervosa.
The American journal of cardiology.
94(9):1217-20
[PMID] 15518630.
2004
Serum lithium concentration can be used to assess dietary compliance in adults.
The Journal of nutrition.
134(11):3133-6
[PMID] 15514287.
2004
Variability in energy expenditure and its components.
Current opinion in clinical nutrition and metabolic care.
7(6):599-605
[PMID] 15534426.
2003
Relation between calcium intake and fat oxidation in adult humans.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.
27(2):196-203
[PMID] 12586999.
2002
From instinct to intellect: the challenge of maintaining healthy weight in the modern world.
Obesity reviews : an official journal of the International Association for the Study of Obesity.
3(2):69-74
[PMID] 12120422.
2000
Comparison of risk factors for obesity in young, nonobese African-American and Caucasian women.
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity.
24(11):1514-22
[PMID] 11126350.
2000
Percent body fat and lean mass explain the gender difference in leptin: analysis and interpretation of leptin in Hispanic and non-Hispanic white adults.
Obesity research.
8(8):543-52
[PMID] 11156429.
2000
Seasonal variation in lipoprotein lipase and plasma lipids in physically active, normal weight humans.
The Journal of clinical endocrinology and metabolism.
85(9):3065-8
[PMID] 10999787.
1999
Leptin levels in restricting and purging anorectics.
The International journal of eating disorders.
26(2):189-94
[PMID] 10422608.
1998
Drugs causing dyslipoproteinemia.
Endocrinology and metabolism clinics of North America.
27(3):677-97
[PMID] 9785060.
1997
Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion.
The Journal of clinical endocrinology and metabolism.
82(12):4139-43
[PMID] 9398728.
An Iterative Process for Identifying Pediatric Patients With Type 1 Diabetes: Retrospective Observational Study (Preprint)
.
[DOI] 10.2196/preprints.18874.
Noninvasive Diagnosis of Nonalcoholic Steatohepatitis and Advanced Liver Fibrosis Using Machine Learning Methods: Comparative Study With Existing Quantitative Risk Scores (Preprint)
.
[DOI] 10.2196/preprints.36997.
Grants
Sep 2022
ACTIVE
Diabetes Risk after COVID-19 in Racial and Ethnic Minority Communities
Role: Principal Investigator
Funding: EMORY UNIV
via NATL INST OF HLTH NIDDK
Mar 2022
ACTIVE
Medication Adherence and Cardio-Metabolic Control Indicators among Adult American Indians Receiving Tribal Health Services
Role: Co-Investigator
Funding: NATL INST OF HLTH NINR
Oct 2021
– Sep 2022
Comparative Cardiovascular and Renal Effectiveness and Safety of Empagliflozin in Patients with Type 2 Diabetes, with and without Baseline Kidney Disease in the United States
Role: Principal Investigator
Funding: DUKE UNIVERSITY
via BOEHRINGER INGELHEIM INTL GmbH
Jan 2021
– Nov 2021
Non-Alcoholic Steatohepatitis (NASH) Prevalence Estimation and Risk Stratification using a Multi-System Regional Research Network Database
Role: Principal Investigator
Funding: UNIV OF PITTSBURGH
Dec 2020
– Nov 2022
Novel, High-Impact Studies Evaluating Health System and Healthcare Professional Responsiveness to COVID-19
Role: Co-Investigator
Funding: AGCY HEALTHCARE RES AND QUALITY
Sep 2020
ACTIVE
Using Real-world Data to Assess the Burden of Diabetes in Children and Adolescents in Florida
Role: Co-Investigator
Funding: CTRS FOR DISEASE CONTROL AND PREVENTION
Apr 2020
ACTIVE
Phentermine/tOpiramate to end Obesity and Uric acid stones Trial (POuND OUT)
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2019
ACTIVE
Project ECHO T1D: HCT Trial
Role: Project Manager
Funding: STANFORD UNIV
via HELMSLEY CHARITABLE TRUST, LEONA & HARRY
Aug 2018
– May 2021
Acceptance-Based Therapy Weight Loss Intervention for Adolescents: A Pilot, Randomized Controlled Trial
Role: Other
Funding: NATL INST OF HLTH NHLBI
Dec 2017
– Aug 2018
The Mid-South CDRN
Role: Co-Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER
via PATIENT-CENTERED OUTCOMES RES INST
Apr 2015
– Jun 2021
Clinical and Translational Science Institute (CTSI)
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
Education
Fellowship – Endocrinology, Diabetes and Metabolism
1997
·
University of Colorado
Residency – Internal Medicine
1994
·
University of Colorado
Internship – Internal Medicine
1992
·
University of Colorado
Medical Degree
1991
·
University of Colorado
Contact Details
Phones:
- Business:
- (352) 273-8655
Emails:
- Business:
- wdonahoo@ufl.edu
Addresses:
- Business Mailing:
-
PO Box 100226
GAINESVILLE FL 32610 - Business Street:
-
1600 SW ARCHER RD
GAINESVILLE FL 32610