Jasenka Zubcevic

Jasenka Zubcevic,

Assistant Professor

Department: Department of Physiological Sciences
Business Phone: (352) 294-4057
Business Email: jasenkaz@ufl.edu

Accomplishments

Best Presentation Award
2013 · American Heart Association
Best Presentation Award
2011 · American Heart Association
New Investigator Travel Award
2011 · American Heart Association
Trainee Award
2006 · Donald J. Reiss Memorial

Teaching Profile

Courses Taught
2019
VME6905 Problems in Veterinary Medical Sciences
2015-2019
VEM5110 Animal Systems 1
2018
VEM5991 Clkship Indiv Invest
2018
VME7980 Research for Doctoral Dissertation
2018
GMS7979 Advanced Research
2016
VEM5111 Animal Systems 2
2016
VME6932 Seminar in Physiological Sciences
2015
VEM5115 Veterinary Histology

Research Profile

Neural control of cardiovascular physiology, neurogenic hypertension, bone marrow immune responses in cardiovascular and metabolic diseases, the gut-brain axis in cardiovascular diseases.

Open Researcher and Contributor ID (ORCID)

0000-0003-3840-3211

Publications

2022
Identification of a Gut Commensal That Compromises the Blood Pressure-Lowering Effect of Ester Angiotensin-Converting Enzyme Inhibitors.
Hypertension (Dallas, Tex. : 1979). 79(8):1591-1601 [DOI] 10.1161/HYPERTENSIONAHA.121.18711. [PMID] 35538603.
2022
Measures of cardiovascular function suggest autonomic nervous system dysregulation after surgical induction of joint injury in the male Lewis rat.
Osteoarthritis and cartilage. 30(4):586-595 [DOI] 10.1016/j.joca.2021.12.008. [PMID] 35017058.
2022
Nicotine Exposure during Rodent Pregnancy Alters the Composition of Maternal Gut Microbiota and Abundance of Maternal and Amniotic Short Chain Fatty Acids
Metabolites. 12(8) [DOI] 10.3390/metabo12080735. [PMID] 36005607.
2022
Tumor Necrosis Factor Alpha and the Gastrointestinal Epithelium: Implications for the Gut-Brain Axis and Hypertension.
Cellular and molecular neurobiology. 42(2):419-437 [DOI] 10.1007/s10571-021-01044-z. [PMID] 33594519.
2021
Ain’t No Sunshine When They’re Gone: Rendering the Gut Microbiota “Homeless” by Cecectomy Reveals Their True Thermogenic Potential.
Function (Oxford, England). 2(3) [DOI] 10.1093/function/zqab020. [PMID] 35330674.
2021
Central Administration of Hydrogen Sulfide Donor NaHS Reduces Iba1-Positive Cells in the PVN and Attenuates Rodent Angiotensin II Hypertension.
Frontiers in neuroscience. 15 [DOI] 10.3389/fnins.2021.690919. [PMID] 34602965.
2021
Impact of Nutritional Epigenetics in Essential Hypertension: Targeting microRNAs in the Gut-Liver Axis.
Current hypertension reports. 23(5) [DOI] 10.1007/s11906-021-01142-9. [PMID] 33961141.
2020
Gastrointestinal dysbiosis following diethylhexyl phthalate exposure in zebrafish (Danio rerio): Altered microbial diversity, functionality, and network connectivity.
Environmental pollution (Barking, Essex : 1987). 265(Pt B) [DOI] 10.1016/j.envpol.2020.114496. [PMID] 32806437.
2020
Genetic ablation of bone marrow beta-adrenergic receptors in mice modulates miRNA-transcriptome networks of neuroinflammation in the paraventricular nucleus.
Physiological genomics. 52(4):169-177 [DOI] 10.1152/physiolgenomics.00001.2020. [PMID] 32089076.
2020
Ghrelin Signaling Affects Feeding Behavior, Metabolism, and Memory through the Vagus Nerve
Current Biology. 30(22):4510-4518.e6 [DOI] 10.1016/j.cub.2020.08.069. [PMID] 32946754.
2020
Gut microbiota and neuroinflammation in pathogenesis of hypertension: A potential role for hydrogen sulfide.
Pharmacological research. 153 [DOI] 10.1016/j.phrs.2020.104677. [PMID] 32023431.
2020
Pulmonary arterial hypertension-associated changes in gut pathology and microbiota.
ERJ open research. 6(3) [DOI] 10.1183/23120541.00253-2019. [PMID] 32743008.
2020
The importance of bone marrow and the immune system in driving increases in blood pressure and sympathetic nerve activity in hypertension
Experimental Physiology. 105(11):1815-1826 [DOI] 10.1113/ep088247.
2020
The importance of bone marrow and the immune system in driving increases in blood pressure and sympathetic nerve activity in hypertension
Experimental Physiology. 105(11):1815-1826 [DOI] 10.1113/ep088247.
2019
Attenuated Amiloride-Sensitive Current and Augmented Calcium-Activated Chloride Current in Marsh Rice Rat (Oryzomys palustris) Airways.
iScience. 19:737-748 [DOI] 10.1016/j.isci.2019.08.011. [PMID] 31491720.
2019
Comparison of Isoflurane, Ketamine-Dexmedetomidine, and Ketamine-Xylazine for General Anesthesia during Oral Procedures in Rice Rats (Oryzomys palustris).
Journal of the American Association for Laboratory Animal Science : JAALAS. 58(1):40-49 [DOI] 10.30802/AALAS-JAALAS-18-000032. [PMID] 30572978.
2019
Elevated bone marrow sympathetic drive precedes systemic inflammation in angiotensin II hypertension.
American journal of physiology. Heart and circulatory physiology. 317(2):H279-H289 [DOI] 10.1152/ajpheart.00510.2018. [PMID] 31150271.
2019
Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension.
Circulation research. 125(1):104-116 [DOI] 10.1161/CIRCRESAHA.119.313965. [PMID] 31219753.
2019
Impaired butyrate absorption in the proximal colon, low serum butyrate and diminished central effects of butyrate on blood pressure in spontaneously hypertensive rats.
Acta physiologica (Oxford, England). 226(2) [DOI] 10.1111/apha.13256. [PMID] 30656835.
2019
Sustained Captopril-Induced Reduction in Blood Pressure Is Associated With Alterations in Gut-Brain Axis in the Spontaneously Hypertensive Rat.
Journal of the American Heart Association. 8(4) [DOI] 10.1161/JAHA.118.010721. [PMID] 30755073.
2018
Butyrate regulates inflammatory cytokine expression without affecting oxidative respiration in primary astrocytes from spontaneously hypertensive rats.
Physiological reports. 6(14) [DOI] 10.14814/phy2.13732. [PMID] 30039527.
2018
Cocaine differentially affects synaptic activity in memory and midbrain areas of female and male rats: an in vivo MEMRI study.
Brain imaging and behavior. 12(1):201-216 [DOI] 10.1007/s11682-017-9691-1. [PMID] 28236167.
2018
Increased Abundance of Lactobacillales in the Colon of Beta-Adrenergic Receptor Knock Out Mouse Is Associated With Increased Gut Bacterial Production of Short Chain Fatty Acids and Reduced IL17 Expression in Circulating CD4+ Immune Cells.
Frontiers in physiology. 9 [DOI] 10.3389/fphys.2018.01593. [PMID] 30483153.
2018
Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension.
Hypertension (Dallas, Tex. : 1979). 71(6):1156-1163 [DOI] 10.1161/HYPERTENSIONAHA.118.10934. [PMID] 29712738.
2018
MEMRI reveals altered activity in brain regions associated with anxiety, locomotion, and cardiovascular reactivity on the elevated plus maze in the WKY vs SHR rats.
Brain imaging and behavior. 12(5):1318-1331 [DOI] 10.1007/s11682-017-9798-4. [PMID] 29181695.
2017
A Single Angiotensin II Hypertensive Stimulus Is Associated with Prolonged Neuronal and Immune System Activation in Wistar-Kyoto Rats.
Frontiers in physiology. 8 [DOI] 10.3389/fphys.2017.00592. [PMID] 28912720.
2017
Gut-Brain Axis in Regulation of Blood Pressure.
Frontiers in physiology. 8 [DOI] 10.3389/fphys.2017.00845. [PMID] 29118721.
2017
Hypertension-Linked Pathophysiological Alterations in the Gut.
Circulation research. 120(2):312-323 [DOI] 10.1161/CIRCRESAHA.116.309006. [PMID] 27799253.
2017
Shifts in the Gut Microbiota Composition Due to Depleted Bone Marrow Beta Adrenergic Signaling Are Associated with Suppressed Inflammatory Transcriptional Networks in the Mouse Colon.
Frontiers in physiology. 8 [DOI] 10.3389/fphys.2017.00220. [PMID] 28446880.
2017
Transcriptional networks in rodent models support a role for gut-brain communication in neurogenic hypertension: a review of the evidence.
Physiological genomics. 49(7):327-338 [DOI] 10.1152/physiolgenomics.00010.2017. [PMID] 28550087.
2016
Loss of bone marrow adrenergic beta 1 and 2 receptors modifies transcriptional networks, reduces circulating inflammatory factors, and regulates blood pressure.
Physiological genomics. 48(7):526-36 [DOI] 10.1152/physiolgenomics.00039.2016. [PMID] 27235450.
2015
Gut dysbiosis is linked to hypertension.
Hypertension (Dallas, Tex. : 1979). 65(6):1331-40 [DOI] 10.1161/HYPERTENSIONAHA.115.05315. [PMID] 25870193.
2015
Involvement of bone marrow cells and neuroinflammation in hypertension.
Circulation research. 117(2):178-91 [DOI] 10.1161/CIRCRESAHA.117.305853. [PMID] 25963715.
2014
Altered inflammatory response is associated with an impaired autonomic input to the bone marrow in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979). 63(3):542-50 [DOI] 10.1161/HYPERTENSIONAHA.113.02722. [PMID] 24366083.
2014
Functional neural-bone marrow pathways: implications in hypertension and cardiovascular disease.
Hypertension (Dallas, Tex. : 1979). 63(6):e129-39 [DOI] 10.1161/HYPERTENSIONAHA.114.02440. [PMID] 24688127.
2014
Iba1+Microglia/Macrophages in the Rat Hypothalamic Paraventricular Nucleus Are Both Resident and Bone Marrow-Derived in Ang II Induced Hypertension
The FASEB's Journal. 28(1, S)
2013
Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979). 61(6):1328-33 [DOI] 10.1161/HYPERTENSIONAHA.111.00156. [PMID] 23547238.
2013
Dysfunctional brain-bone marrow communication: a paradigm shift in the pathophysiology of hypertension.
Current hypertension reports. 15(4):377-89 [DOI] 10.1007/s11906-013-0361-4. [PMID] 23715920.
2013
Increased Expression of Prorenin Receptor (Prr) in the Nts of Spontaneously Hypertensive Rats (Shr) May Be a Compensatory Mechanism of Hypertension
The FASEB's Journal. 27
2013
Neuroimmune communication in hypertension and obesity: a new therapeutic angle?
Pharmacology & therapeutics. 138(3):428-40 [DOI] 10.1016/j.pharmthera.2013.02.005. [PMID] 23458610.
2013
Nucleus of the solitary tract (pro)renin receptor-mediated antihypertensive effect involves nuclear factor-κB-cytokine signaling in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979). 61(3):622-7 [DOI] 10.1161/HYPERTENSIONAHA.111.199836. [PMID] 23319541.
2013
Role of Microglia Activation in Neurogenic Hypertension
Glia. 61
2012
Brain-mediated dysregulation of the bone marrow activity in angiotensin II-induced hypertension.
Hypertension (Dallas, Tex. : 1979). 60(5):1316-23 [DOI] 10.1161/HYPERTENSIONAHA.112.199547. [PMID] 23045460.
2012
Dysfunctional Bone Marrow-Derived Endothelial Progenitor Cells in Chronic Ang II Infusion Rat Model of Hypertension
The FASEB's Journal. 26
2012
Nts (Pro)Renin Receptor (Prr)-Mediated Antihypertensive Effect Involves Nf-Kappab-Cytokine Signaling in the Spontaneously Hypertensive Rats (Shr)
The FASEB's Journal. 26
2011
(Pro)Renin Receptor (Prr) Mediates Antihypertensive Effects in the Necleus of Solitary Tract (Nts) of Spontaneously Hypertensive Rats (Shr)
Hypertension. 58
2011
Autonomic-immune-vascular interaction: an emerging concept for neurogenic hypertension.
Hypertension (Dallas, Tex. : 1979). 57(6):1026-33 [DOI] 10.1161/HYPERTENSIONAHA.111.169748. [PMID] 21536990.
2011
Dysfunctional Bone Marrow-Derived Endothelial Progenitor Cells (Epcs) in Rat Models of Neurogenic Hypertension
Hypertension. 58:E97-E98
2010
Role of GABAergic neurones in the nucleus tractus solitarii in modulation of cardiovascular activity.
Experimental physiology. 95(9):909-18 [DOI] 10.1113/expphysiol.2010.054007. [PMID] 20591977.
2009
Chronic blockade of phosphatidylinositol 3-kinase in the nucleus tractus solitarii is prohypertensive in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979). 53(1):97-103 [DOI] 10.1161/HYPERTENSIONAHA.108.122341. [PMID] 19015400.
2009
Shift to an involvement of phosphatidylinositol 3-kinase in angiotensin II actions on nucleus tractus solitarii neurons of the spontaneously hypertensive rat.
Circulation research. 105(12):1248-55 [DOI] 10.1161/CIRCRESAHA.109.208926. [PMID] 19850939.
2004
Cloning and characterization of a secreted form of angiotensin-converting enzyme 2.
Regulatory peptides. 122(2):61-7 [PMID] 15380922.
2004
Structure-based discovery of a novel angiotensin-converting enzyme 2 inhibitor.
Hypertension (Dallas, Tex. : 1979). 44(6):903-6 [PMID] 15492138.

Grants

Sep 2017 – Aug 2019
High salt diet potentiation of AngII HTN : Novel role for Th17 cell infiltration into the PVN
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Aug 2016 – Dec 2021
ACE2, Brain, Gut Dysbiosis in Pulmonary Hypertension
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2016 – Jun 2020
Miscellaneous Donors 209
Role: Principal Investigator
Funding: MISCELLANEOUS DONORS
Apr 2016 – Sep 2021
Brain-Gut Microbiome-Immune Axis in Hypertension
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Jan 2014 – Jun 2018
Altered sympathetic activity to the bone marrow in neurogenic hypertension
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION

Education

Research Assistant Professor, Department of Physiology and Functional Genomics
2013-2014 · University of Florida
Post-doctoral fellow, Department of Physiology and Functional Genomics
2010-2013 · University of Florida
PhD in Physiology
2008 · Bristol Heart Institute, University of Bristol
BSc in Pharmacology
2003 · Bristol Heart Institute, University of Bristol

Contact Details

Phones:
Business:
(352) 294-4057
Emails:
Business:
jasenkaz@ufl.edu
Addresses:
Business Mailing:
PO Box 100274
GAINESVILLE FL 32610