Glenn Walter

Glenn Walter, PhD

Professor and Vice-Chair

Department: Department of Physiology and Aging
Business Email: glennw@ufl.edu

About Glenn Walter

Throughout my career, I have pushed cutting-edge magnetic resonance (MR) technology in order to answer clinically relevant physiology and metabolomics questions. Diverse collaborations with investigators with different backgrounds (physiologist, cell biologist, engineers, biochemist, physicists, clinicians, etc) have helped me to successfully tackle common problems. My primary area of focus had been the development of translational noninvasive imaging and spectroscopy techniques for clinical applications, with extensive experiences in both animal models and patients. I had the good fortune of performing my Ph.D. work focused on in vivo metabolism using MR under the guidance of the late Drs. Jack Leigh, Britton Chance, and Mildred Cohn at the University of Pennsylvania. With this basic training in biophysics and metabolism, my post-doctoral fellowship was performed with Dr. H. Lee Sweeney in the Department of Physiology at the University of Pennsylvania. During my time as a post-doctoral fellow, I expanded my knowledge of MR to study the in vivo physiology and metabolism of dystrophic muscle, prior to and following gene transfer of therapeutic genes as well as MR marker genes encoding for unique metabolic pathways. Ever since then, I have been using these combined biophysics, MR, and physiology foundations to develop comprehensive ways to monitor and study muscle structure, function, and metabolism in vivo using novel MR and optical imaging techniques. The University of Florida has provided a rich environment to build my research program, with UF being home to the National High Magnetic Field Laboratory (NHMFL), McKnight Brain Institute, Clinical Translational Sciences, Myology, and Powell Gene Therapy Institutes. I was also a founding member of Southeast Center for Integrated Metabolism, funded through the NIH common fund, and the director of its NMR metabolomics core. I have greater than 20 yrs. of experience with skeletal muscle research, and lead data coordination and analysis cores for multicenter NIH studies focused on the use of MR Imaging/Spectroscopy in preclinical models and in subjects with a range of different types of muscular dystrophy. Specifically, I have extensive experience with MR sequence design, implementation, and processing of MRI/MRS data in neuromuscular diseases on multiple platforms.

Additional Positions:
Professor and Vice-Chair
2022 – Current ·

Teaching Profile

Courses Taught
2019-2024
GMS6476 Fundamentals of Skeletal Muscle
2015-2024
GMS6491 Journal Club in Physiology
2011-2023
DEN5120C Physiology
2019-2020,2024
GMS6471 Fundamentals of Physiology and Functional Genomics I
2018
GMS7593 Topics in Pharmacology and Toxicology
2018
CHM7979 Advanced Research
2018
GMS7980 Research for Doctoral Dissertation
2018
EML7980 Research for Doctoral Dissertation
2018
BME7980 Research for Doctoral Dissertation
2013-2014
BMS6031 Foundations of Med
2007-2008
GMS6008 Fundamentals of Physiology and Functional Genomics
2020-2022
BMS3521 Human Physiology in Translation
2021
GMS5905 Special Topics in Biomedical Sciences
2023-2024
BMS6635 Derm and Msk
2024
GMS6473 Fundamentals of Physiology and Functional Genomics III
2024
GMS6472 Fundamentals of Physiology and Functional Genomics II
2024
BMS6633 The Cv System

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-7346-2244

Publications

2024
Clinical importance of changes in magnetic resonance biomarkers for Duchenne muscular dystrophy.
Annals of clinical and translational neurology. 11(1):67-78 [DOI] 10.1002/acn3.51933. [PMID] 37932907.
2023
A comprehensive study of skeletal muscle imaging in FHL1-related reducing body myopathy.
Annals of clinical and translational neurology. 10(8):1442-1455 [DOI] 10.1002/acn3.51834. [PMID] 37483011.
2023
Blocking muscle wasting via deletion of the muscle-specific E3 ligase MuRF1 impedes pancreatic tumor growth.
Communications biology. 6(1) [DOI] 10.1038/s42003-023-04902-2. [PMID] 37179425.
2023
Blocking muscle wasting via deletion of the muscle-specific E3 ubiquitin ligase MuRF1 impedes pancreatic tumor growth.
Research square. [DOI] 10.21203/rs.3.rs-2524562/v1. [PMID] 36798266.
2023
Magnetic resonance quantification of skeletal muscle lipid infiltration in a humanized mouse model of Duchenne muscular dystrophy.
NMR in biomedicine. 36(3) [DOI] 10.1002/nbm.4869. [PMID] 36331178.
2023
Multivariate modeling of magnetic resonance biomarkers and clinical outcome measures for Duchenne muscular dystrophy clinical trials.
CPT: pharmacometrics & systems pharmacology. 12(10):1437-1449 [DOI] 10.1002/psp4.13021. [PMID] 37534782.
2022
Characterizing Expiratory Respiratory Muscle Degeneration in Duchenne Muscular Dystrophy Using MRI.
Chest. 161(3):753-763 [DOI] 10.1016/j.chest.2021.08.078. [PMID] 34536384.
2022
Development of Contractures in DMD in Relation to MRI-Determined Muscle Quality and Ambulatory Function.
Journal of neuromuscular diseases. 9(2):289-302 [DOI] 10.3233/JND-210731. [PMID] 35124659.
2022
Effects of muscle damage on 31 phosphorus magnetic resonance spectroscopy indices of energetic status and sarcolemma integrity in young mdx mice.
NMR in biomedicine. 35(3) [DOI] 10.1002/nbm.4659. [PMID] 34841594.
2022
Evaluating Genetic Modifiers of Duchenne Muscular Dystrophy Disease Progression Using Modeling and MRI.
Neurology. 99(21):e2406-e2416 [DOI] 10.1212/WNL.0000000000201163. [PMID] 36240102.
2022
Isolated murine skeletal muscles utilize pyruvate over glucose for oxidation.
Metabolomics : Official journal of the Metabolomic Society. 18(12) [DOI] 10.1007/s11306-022-01948-x. [PMID] 36480060.
2022
Longitudinal changes in cardiac function in Duchenne muscular dystrophy population as measured by magnetic resonance imaging.
BMC cardiovascular disorders. 22(1) [DOI] 10.1186/s12872-022-02688-5. [PMID] 35681116.
2022
Step Activity Monitoring in Boys with Duchenne Muscular Dystrophy and its Correlation with Magnetic Resonance Measures and Functional Performance.
Journal of neuromuscular diseases. 9(3):423-436 [DOI] 10.3233/JND-210746. [PMID] 35466946.
2021
A form of muscular dystrophy associated with pathogenic variants in JAG2.
American journal of human genetics. 108(5):840-856 [DOI] 10.1016/j.ajhg.2021.03.020. [PMID] 33861953.
2021
A form of muscular dystrophy associated with pathogenic variants in JAG2.
American journal of human genetics. 108(6) [DOI] 10.1016/j.ajhg.2021.04.018. [PMID] 34087166.
2021
Assessment of rAAVrh.74.MHCK7.micro-dystrophin Gene Therapy Using Magnetic Resonance Imaging in Children With Duchenne Muscular Dystrophy.
JAMA network open. 4(1) [DOI] 10.1001/jamanetworkopen.2020.31851. [PMID] 33394000.
2021
Disease-modifying effects of edasalonexent, an NF-κB inhibitor, in young boys with Duchenne muscular dystrophy: Results of the MoveDMD phase 2 and open label extension trial.
Neuromuscular disorders : NMD. 31(5):385-396 [DOI] 10.1016/j.nmd.2021.02.001. [PMID] 33678513.
2021
Functional heart recovery in an adult mammal, the spiny mouse.
International journal of cardiology. 338:196-203 [DOI] 10.1016/j.ijcard.2021.06.015. [PMID] 34126132.
2021
Magnetization Transfer Ratio in Lower Limbs of Late Onset Pompe Patients Correlates With Intramuscular Fat Fraction and Muscle Function Tests.
Frontiers in neurology. 12 [DOI] 10.3389/fneur.2021.634766. [PMID] 33796064.
2021
Postcontractile blood oxygenation level-dependent (BOLD) response in Duchenne muscular dystrophy.
Journal of applied physiology (Bethesda, Md. : 1985). 131(1):83-94 [DOI] 10.1152/japplphysiol.00634.2020. [PMID] 34013753.
2021
Safety, feasibility, and efficacy of strengthening exercise in Duchenne muscular dystrophy.
Muscle & nerve. 63(3):320-326 [DOI] 10.1002/mus.27137. [PMID] 33295018.
2021
Skeletal muscle magnetic resonance imaging in Pompe disease.
Muscle & nerve. 63(5):640-650 [DOI] 10.1002/mus.27099. [PMID] 33155691.
2020
Characterizing Enrollment in Observational Studies of Duchenne Muscular Dystrophy by Race and Ethnicity.
Journal of neuromuscular diseases. 7(2):167-173 [DOI] 10.3233/JND-190447. [PMID] 31929119.
2020
Conference report on contractures in musculoskeletal and neurological conditions.
Muscle & nerve. 61(6):740-744 [DOI] 10.1002/mus.26845. [PMID] 32108365.
2020
Diaphragm weakness and proteomics (global and redox) modifications in heart failure with reduced ejection fraction in rats.
Journal of molecular and cellular cardiology. 139:238-249 [DOI] 10.1016/j.yjmcc.2020.02.002. [PMID] 32035137.
2020
Lower Extremity Muscle Involvement in the Intermediate and Bethlem Myopathy Forms of COL6-Related Dystrophy and Duchenne Muscular Dystrophy: A Cross-Sectional Study.
Journal of neuromuscular diseases. 7(4):407-417 [DOI] 10.3233/JND-190457. [PMID] 32538860.
2020
Magnetic Resonance Imaging Studies in Duchenne Muscular Dystrophy: Linking Findings to the Physical Therapy Clinic.
Physical therapy. 100(11):2035-2048 [DOI] 10.1093/ptj/pzaa140. [PMID] 32737968.
2020
MEF2c-Dependent Downregulation of Myocilin Mediates Cancer-Induced Muscle Wasting and Associates with Cachexia in Patients with Cancer.
Cancer research. 80(9):1861-1874 [DOI] 10.1158/0008-5472.CAN-19-1558. [PMID] 32132110.
2020
Modeling disease trajectory in Duchenne muscular dystrophy.
Neurology. 94(15):e1622-e1633 [DOI] 10.1212/WNL.0000000000009244. [PMID] 32184340.
2020
MR biomarkers predict clinical function in Duchenne muscular dystrophy.
Neurology. 94(9):e897-e909 [DOI] 10.1212/WNL.0000000000009012. [PMID] 32024675.
2020
Upper and Lower Extremities in Duchenne Muscular Dystrophy Evaluated with Quantitative MRI and Proton MR Spectroscopy in a Multicenter Cohort
Radiology. 295(3):616-625 [DOI] 10.1148/radiol.2020192210. [PMID] 32286193.
2019
Age‐dependent changes in metabolite profile and lipid saturation in dystrophic mice
NMR in Biomedicine. 32(5) [DOI] 10.1002/nbm.4075. [PMID] 30848538.
2019
Effects of PDE5 inhibition on dystrophic muscle following an acute bout of downhill running and endurance training.
Journal of applied physiology (Bethesda, Md. : 1985). 126(6):1737-1745 [DOI] 10.1152/japplphysiol.00664.2018. [PMID] 30946638.
2019
Exploration of New Contrasts, Targets, and MR Imaging and Spectroscopy Techniques for Neuromuscular Disease – A Workshop Report of Working Group 3 of the Biomedicine and Molecular Biosciences COST Action BM1304 MYO-MRI.
Journal of neuromuscular diseases. 6(1):1-30 [DOI] 10.3233/JND-180333. [PMID] 30714967.
2019
Imaging respiratory muscle quality and function in Duchenne muscular dystrophy.
Journal of neurology. 266(11):2752-2763 [DOI] 10.1007/s00415-019-09481-z. [PMID] 31350642.
2019
Magnetic resonance imaging characteristics of injection site reactions after long-term subcutaneous delivery of drisapersen.
European journal of pediatrics. 178(5):777-778 [DOI] 10.1007/s00431-019-03349-0. [PMID] 30790036.
2019
Texture Analysis for Muscular Dystrophy Classification in MRI with Improved Class Activation Mapping.
Pattern recognition. 86:368-375 [DOI] 10.1016/j.patcog.2018.08.012. [PMID] 31105339.
2018
Leg muscle MRI in identical twin boys with duchenne muscular dystrophy.
Muscle & nerve. [DOI] 10.1002/mus.26081. [PMID] 29365354.
2018
Longitudinal timed function tests in Duchenne muscular dystrophy: ImagingDMD cohort natural history.
Muscle & nerve. 58(5):631-638 [DOI] 10.1002/mus.26161. [PMID] 29742798.
2018
Skeletal muscle magnetic resonance biomarkers correlate with function and sentinel events in Duchenne muscular dystrophy.
PloS one. 13(3) [DOI] 10.1371/journal.pone.0194283. [PMID] 29554116.
2018
Skeletal muscle overexpression of nicotinamide phosphoribosyl transferase in mice coupled with voluntary exercise augments exercise endurance.
Molecular metabolism. 7:1-11 [DOI] 10.1016/j.molmet.2017.10.012. [PMID] 29146412.
2018
Two-Year Longitudinal Changes in Lower Limb Strength and Its Relation to Loss in Function in a Large Cohort of Patients With Duchenne Muscular Dystrophy.
American journal of physical medicine & rehabilitation. 97(10):734-740 [DOI] 10.1097/PHM.0000000000000957. [PMID] 29734234.
2017
13C/31P MRS Metabolic Biomarkers of Disease Progression and Response to AAV Delivery of hGAA in a Mouse Model of Pompe Disease.
Molecular therapy. Methods & clinical development. 7:42-49 [DOI] 10.1016/j.omtm.2017.09.002. [PMID] 29018835.
2017
Contrast-Enhanced Near-Infrared Optical Imaging Detects Exacerbation and Amelioration of Murine Muscular Dystrophy.
Molecular imaging. 16 [DOI] 10.1177/1536012117732439. [PMID] 29271299.
2017
Duchenne Regulatory Science Consortium Meeting on Disease Progression Modeling for Duchenne Muscular Dystrophy.
PLoS currents. 9 [DOI] 10.1371/currents.md.83071bbd728982f2f1073f4950e03586. [PMID] 28228973.
2017
Magnetic resonance imaging of the proximal upper extremity musculature in boys with Duchenne muscular dystrophy.
Journal of neurology. 264(1):64-71 [DOI] 10.1007/s00415-016-8311-0. [PMID] 27778157.
2017
Magnetic Resonance Microscopy (MRM) of Single Mammalian Myofibers and Myonuclei.
Scientific reports. 7 [DOI] 10.1038/srep39496. [PMID] 28045071.
2017
Magnetic Resonance Monitoring of Disease Progression in mdx Mice on Different Genetic Backgrounds.
The American journal of pathology. 187(9):2060-2070 [DOI] 10.1016/j.ajpath.2017.05.010. [PMID] 28826559.
2017
Multi-slice MRI reveals heterogeneity in disease distribution along the length of muscle in Duchenne muscular dystrophy.
Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology. 36(3):151-162 [PMID] 29774305.
2017
Near Infrared Visible Biocompatible Particles Maintain Optical Signal in Dystrophic Muscle
Journal of Biomedical Nanotechnology. 13(5):575-582 [DOI] 10.1166/jbn.2017.2371.
2017
Quantifying fat replacement of muscle by quantitative MRI in muscular dystrophy.
Journal of neurology. 264(10):2053-2067 [DOI] 10.1007/s00415-017-8547-3. [PMID] 28669118.
2016
Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.
Cardiovascular research. 111(1):34-43 [DOI] 10.1093/cvr/cvw069. [PMID] 27025239.
2016
Age-related T2 changes in hindlimb muscles of mdx mice.
Muscle & nerve. 53(1):84-90 [DOI] 10.1002/mus.24675. [PMID] 25846867.
2016
Chemosensitizing AML cells by targeting bone marrow endothelial cells.
Experimental hematology. 44(5):363-377.e5 [DOI] 10.1016/j.exphem.2016.02.003. [PMID] 26898708.
2016
Disease-modifying effects of orally bioavailable NF-κB inhibitors in dystrophin-deficient muscle.
JCI insight. 1(21) [DOI] 10.1172/jci.insight.90341. [PMID] 28018975.
2016
MRI quantifies neuromuscular disease progression.
The Lancet. Neurology. 15(1):26-8 [DOI] 10.1016/S1474-4422(15)00320-8. [PMID] 26549781.
2016
Multicenter prospective longitudinal study of magnetic resonance biomarkers in a large duchenne muscular dystrophy cohort.
Annals of neurology. 79(4):535-47 [DOI] 10.1002/ana.24599. [PMID] 26891991.
2016
Near-Infrared Optical Imaging Noninvasively Detects Acutely Damaged Muscle.
The American journal of pathology. 186(10):2692-700 [DOI] 10.1016/j.ajpath.2016.06.019. [PMID] 27565039.
2016
Tadalafil Treatment Delays the Onset of Cardiomyopathy in Dystrophin-Deficient Hearts.
Journal of the American Heart Association. 5(8) [DOI] 10.1161/JAHA.116.003911. [PMID] 27506543.
2015
Correcting Neuromuscular Deficits With Gene Therapy in Pompe Disease.
Annals of neurology. 78(2):222-34 [DOI] 10.1002/ana.24433. [PMID] 25925726.
2015
Endurance training ameliorates complex 3 deficiency in a mouse model of Barth syndrome.
Journal of inherited metabolic disease. 38(5):915-22 [DOI] 10.1007/s10545-015-9834-8. [PMID] 25860817.
2015
Longitudinal Evaluation of Muscle Composition Using Magnetic Resonance in 4 Boys With Duchenne Muscular Dystrophy: Case Series.
Physical therapy. 95(7):978-88 [DOI] 10.2522/ptj.20140234. [PMID] 25592189.
2015
Magnetic Resonance Assessment of Hypertrophic and Pseudo-Hypertrophic Changes in Lower Leg Muscles of Boys with Duchenne Muscular Dystrophy and Their Relationship to Functional Measurements.
PloS one. 10(6) [DOI] 10.1371/journal.pone.0128915. [PMID] 26103164.
2015
Magnetic Resonance Imaging Is Sensitive to Pathological Amelioration in a Model for Laminin-Deficient Congenital Muscular Dystrophy (MDC1A).
PloS one. 10(9) [DOI] 10.1371/journal.pone.0138254. [PMID] 26379183.
2014
Assessment of intramuscular lipid and metabolites of the lower leg using magnetic resonance spectroscopy in boys with Duchenne muscular dystrophy.
Neuromuscular disorders : NMD. 24(7):574-82 [DOI] 10.1016/j.nmd.2014.03.013. [PMID] 24798221.
2014
Chemical shift-based MRI to measure fat fractions in dystrophic skeletal muscle.
Magnetic resonance in medicine. 72(1):8-19 [DOI] 10.1002/mrm.24917. [PMID] 24006208.
2014
Dysferlin and myoferlin regulate transverse tubule formation and glycerol sensitivity.
The American journal of pathology. 184(1):248-59 [DOI] 10.1016/j.ajpath.2013.09.009. [PMID] 24177035.
2014
Examination of effects of corticosteroids on skeletal muscles of boys with DMD using MRI and MRS.
Neurology. 83(11):974-80 [DOI] 10.1212/WNL.0000000000000775. [PMID] 25098537.
2014
Gene transfer of arginine kinase to skeletal muscle using adeno-associated virus.
Gene therapy. 21(4):387-92 [DOI] 10.1038/gt.2014.9. [PMID] 24572791.
2014
In vivo (31)P NMR spectroscopy assessment of skeletal muscle bioenergetics after spinal cord contusion in rats.
European journal of applied physiology. 114(4):847-58 [DOI] 10.1007/s00421-013-2810-9. [PMID] 24399112.
2014
Longitudinal measurements of MRI-T2 in boys with Duchenne muscular dystrophy: effects of age and disease progression.
Neuromuscular disorders : NMD. 24(5):393-401 [DOI] 10.1016/j.nmd.2013.12.012. [PMID] 24491484.
2014
Magnetic resonance imaging and spectroscopy assessment of lower extremity skeletal muscles in boys with Duchenne muscular dystrophy: a multicenter cross sectional study.
PloS one. 9(9) [DOI] 10.1371/journal.pone.0106435. [PMID] 25203313.
2014
Olanzapine treatment during pregnancy and breastfeeding: a chance for women with psychotic illness?
Psychopharmacology. 231(15):3067-9 [DOI] 10.1007/s00213-014-3647-6. [PMID] 24938920.
2014
¹³C NMR metabolomics: applications at natural abundance.
Analytical chemistry. 86(18):9242-50 [DOI] 10.1021/ac502346h. [PMID] 25140385.
2013
A computerized MRI biomarker quantification scheme for a canine model of Duchenne muscular dystrophy.
International journal of computer assisted radiology and surgery. 8(5):763-74 [DOI] 10.1007/s11548-012-0810-6. [PMID] 23299128.
2013
Fe Doped CdTeS Magnetic Quantum Dots for Bioimaging.
Journal of materials chemistry. B. 1(45):6312-6320 [PMID] 24634776.
2013
Hindlimb muscle morphology and function in a new atrophy model combining spinal cord injury and cast immobilization.
Journal of neurotrauma. 30(3):227-35 [DOI] 10.1089/neu.2012.2504. [PMID] 22985272.
2013
Magnetic Resonance Imaging (Mri) To Evaluate the Effect of Enzyme Replacement Therapy in Late Onset Pompe Disease (Lopd)
Neuromuscular Disorders. 23(9-10) [DOI] 10.1016/j.nmd.2013.06.654.
2013
Magnetic Resonance Imaging and Spectroscopy Detect Changes With Age, Corticosteroid Treatment, and Functional Progression in Dmd
Neuromuscular Disorders. 23(9-10) [DOI] 10.1016/j.nmd.2013.06.599.
2013
Magnetic Resonance Imaging and Spectroscopy To Evaluate Muscle Involvement in Pompe Disease
Molecular Genetics and Metabolism. 108(2) [DOI] 10.1016/j.ymgme.2012.11.059.
2013
Mri Measures of Bone in Duchenne Muscular Dystrophy
Neuromuscular Disorders. 23(9-10) [DOI] 10.1016/j.nmd.2013.06.602.
2013
Overexpression of insulin-like growth factor-1 attenuates skeletal muscle damage and accelerates muscle regeneration and functional recovery after disuse.
Experimental physiology. 98(5):1038-52 [DOI] 10.1113/expphysiol.2012.070722. [PMID] 23291913.
2013
Regenerative responses in slow- and fast-twitch muscles following moderate contusion spinal cord injury and locomotor training.
European journal of applied physiology. 113(1):191-200 [DOI] 10.1007/s00421-012-2429-2. [PMID] 22644570.
2013
Skeletal muscles of ambulant children with Duchenne muscular dystrophy: validation of multicenter study of evaluation with MR imaging and MR spectroscopy.
Radiology. 269(1):198-207 [DOI] 10.1148/radiol.13121948. [PMID] 23696684.
2013
T₂ mapping provides multiple approaches for the characterization of muscle involvement in neuromuscular diseases: a cross-sectional study of lower leg muscles in 5-15-year-old boys with Duchenne muscular dystrophy.
NMR in biomedicine. 26(3):320-8 [DOI] 10.1002/nbm.2851. [PMID] 23044995.
2013
White Matter Integrity After Severe Contusion Spinal Cord Injury Under Different Levels of Activity
Journal of Neurotrauma. 30:A116-A117
2012
An activatable multimodal/multifunctional nanoprobe for direct imaging of intracellular drug delivery.
Biomaterials. 33(5):1500-8 [DOI] 10.1016/j.biomaterials.2011.10.068. [PMID] 22078810.
2012
DNA surface modified gadolinium phosphate nanoparticles as MRI contrast agents.
Bioconjugate chemistry. 23(5):951-7 [DOI] 10.1021/bc200553h. [PMID] 22462809.
2012
Gadolinium-doped silica nanoparticles encapsulating indocyanine green for near infrared and magnetic resonance imaging.
Small (Weinheim an der Bergstrasse, Germany). 8(18):2856-68 [DOI] 10.1002/smll.201200258. [PMID] 22744832.
2012
Long-term correction of very long-chain acyl-coA dehydrogenase deficiency in mice using AAV9 gene therapy.
Molecular therapy : the journal of the American Society of Gene Therapy. 20(6):1131-8 [DOI] 10.1038/mt.2012.39. [PMID] 22395529.
2012
Long-term restoration of cardiac dystrophin expression in golden retriever muscular dystrophy following rAAV6-mediated exon skipping.
Molecular therapy : the journal of the American Society of Gene Therapy. 20(3):580-9 [DOI] 10.1038/mt.2011.264. [PMID] 22146342.
2012
Mri and Dti Characterization of Spinal Cord Severe Contusion Injury in the Rat
The FASEB's Journal. 26
2012
MRI/MRS evaluation of a female carrier of Duchenne muscular dystrophy.
Neuromuscular disorders : NMD. 22 Suppl 2(Suppl 2):S111-21 [DOI] 10.1016/j.nmd.2012.05.013. [PMID] 22980762.
2012
Relationships of thigh muscle contractile and non-contractile tissue with function, strength, and age in boys with Duchenne muscular dystrophy.
Neuromuscular disorders : NMD. 22(1):16-25 [DOI] 10.1016/j.nmd.2011.06.750. [PMID] 21807516.
2012
Use of skeletal muscle MRI in diagnosis and monitoring disease progression in Duchenne muscular dystrophy.
Physical medicine and rehabilitation clinics of North America. 23(1):1-10, ix [DOI] 10.1016/j.pmr.2011.11.004. [PMID] 22239869.
2011
A New Rat Model of Spinal Cord Injury Without Muscle Reloading: Morphological and Functional Assessment By Mr Imaging and (31)P Spectroscopy
Journal of Neurotrauma. 28
2011
Changes in muscle T2 and tissue damage after downhill running in mdx mice.
Muscle & nerve. 43(6):878-86 [DOI] 10.1002/mus.21986. [PMID] 21488051.
2011
Design of a Multi-Center Study To Examine Skeletal Muscles of Children With Duchenne Muscular Dystrophy Using Mri/Mrs
Neuromuscular Disorders. 21(9-10):653-654 [DOI] 10.1016/j.nmd.2011.06.801.
2011
Fluorescent and paramagnetic chitosan nanoparticles that exhibit high magnetic resonance relaxivity: synthesis, characterization and in vitro studies.
Journal of biomedical nanotechnology. 7(5):724-9 [PMID] 22195491.
2011
Long-term systemic myostatin inhibition via liver-targeted gene transfer in golden retriever muscular dystrophy.
Human gene therapy. 22(12):1499-509 [DOI] 10.1089/hum.2011.102. [PMID] 21787232.
2011
Ultra-high-field MRI real-time imaging of HSC engraftment of the bone marrow niche.
Leukemia. 25(8):1223-31 [DOI] 10.1038/leu.2011.72. [PMID] 21494252.
2010
Age-related differences in lower-limb muscle cross-sectional area and torque production in boys with Duchenne muscular dystrophy.
Archives of physical medicine and rehabilitation. 91(7):1051-8 [DOI] 10.1016/j.apmr.2010.03.024. [PMID] 20599043.
2010
Distribution of T2 in the Soleus Muscle of Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Impact of treadmill locomotor training on skeletal muscle IGF1 and myogenic regulatory factors in spinal cord injured rats.
European journal of applied physiology. 109(4):709-20 [DOI] 10.1007/s00421-010-1392-z. [PMID] 20213470.
2010
Impact of viral-mediated IGF-I gene transfer on skeletal muscle following cast immobilization.
American journal of physiology. Endocrinology and metabolism. 299(5):E730-40 [DOI] 10.1152/ajpendo.00230.2010. [PMID] 20739512.
2010
lacZ as a genetic reporter for real-time MRI.
Magnetic resonance in medicine. 63(3):745-53 [DOI] 10.1002/mrm.22235. [PMID] 20146234.
2010
Multimodal nanoparticulate bioimaging contrast agents.
Methods in molecular biology (Clifton, N.J.). 624:67-81 [DOI] 10.1007/978-1-60761-609-2_5. [PMID] 20217589.
2010
Muscle Pathology and Functional Ability in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Nnls Analyses of Skeletal Muscle T2 in Children With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 42
2010
Skeletal Muscle Contractile and Non-Contractile Components in Boys With Duchenne Muscular Dystrophy By Mri
Medicine and Science in Sports and Exercise. 42
2010
The Effect of Igf-I Overexpression in Skeletal Muscle Following Spinal Cord Injury and Locomotor Training
Medicine and Science in Sports and Exercise. 42
2009
Real-time imaging of de novo arteriovenous malformation in a mouse model of hereditary hemorrhagic telangiectasia.
The Journal of clinical investigation. 119(11):3487-96 [DOI] 10.1172/JCI39482. [PMID] 19805914.
2009
Voluntary exercise prevents the obese and diabetic metabolic syndrome of the melanocortin-4 receptor knockout mouse.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 23(2):642-55 [DOI] 10.1096/fj.08-109686. [PMID] 18971258.
2008
A longitudinal study of skeletal muscle following spinal cord injury and locomotor training.
Spinal cord. 46(7):488-93 [DOI] 10.1038/sj.sc.3102169. [PMID] 18283294.
2008
Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse.
NMR in biomedicine. 21(2):101-10 [PMID] 17516466.
2008
Biochemical correction of short-chain acyl-coenzyme A dehydrogenase deficiency after portal vein injection of rAAV8-SCAD.
Human gene therapy. 19(6):579-88 [DOI] 10.1089/hum.2007.168. [PMID] 18500942.
2008
Cardiac overexpression of angiotensin converting enzyme 2 protects the heart from ischemia-induced pathophysiology.
Hypertension (Dallas, Tex. : 1979). 51(3):712-8 [DOI] 10.1161/HYPERTENSIONAHA.107.100693. [PMID] 18250366.
2008
Gold-Speckled Multimodal Nanoparticles for Noninvasive Bioimaging.
Chemistry of materials : a publication of the American Chemical Society. 20(19):6087-6094 [PMID] 19466201.
2008
Locomotor training and muscle function after incomplete spinal cord injury: case series.
The journal of spinal cord medicine. 31(2):185-93 [PMID] 18581666.
2008
Muscle Strength and Functional Status in Boys With Duchenne Muscular Dystrophy
Medicine and Science in Sports and Exercise. 40(5) [DOI] 10.1249/01.mss.0000323019.33764.4c.
2008
Non-invasive assessment of lower extremity muscle composition after incomplete spinal cord injury.
Spinal cord. 46(8):565-70 [DOI] 10.1038/sc.2008.10. [PMID] 18347608.
2007
A quantitative study of bioenergetics in skeletal muscle lacking carbonic anhydrase III using 31P magnetic resonance spectroscopy.
Proceedings of the National Academy of Sciences of the United States of America. 104(1):371-6 [PMID] 17182736.
2007
Ectopic expression of Wnt10b decreases adiposity and improves glucose homeostasis in obese rats.
American journal of physiology. Endocrinology and metabolism. 293(3):E726-36 [PMID] 17578883.
2007
Long-term skeletal muscle protection after gene transfer in a mouse model of LGMD-2D.
Molecular therapy : the journal of the American Society of Gene Therapy. 15(10):1775-81 [PMID] 17653106.
2007
Transcriptional pathways associated with skeletal muscle disuse atrophy in humans.
Physiological genomics. 31(3):510-20 [PMID] 17804603.
2006
Changes in muscle T2 relaxation properties following spinal cord injury and locomotor training.
European journal of applied physiology. 97(3):355-61 [PMID] 16770473.
2006
Deficit in human muscle strength with cast immobilization: contribution of inorganic phosphate.
European journal of applied physiology. 98(1):71-8 [PMID] 16841201.
2006
Lower-extremity muscle cross-sectional area after incomplete spinal cord injury.
Archives of physical medicine and rehabilitation. 87(6):772-8 [PMID] 16731211.
2006
Nanoparticles for bioimaging.
Advances in colloid and interface science. 123-126:471-85 [PMID] 16890182.
2006
Relative contributions of muscle activation and muscle size to plantarflexor torque during rehabilitation after immobilization.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society. 24(8):1729-36 [PMID] 16779833.
2006
Systemic correction of a fatty acid oxidation defect by intramuscular injection of a recombinant adeno-associated virus vector.
Human gene therapy. 17(1):71-80 [PMID] 16409126.
2005
A model of muscle atrophy using cast immobilization in mice.
Muscle & nerve. 32(5):672-4 [PMID] 16025524.
2005
Changes in inorganic phosphate and force production in human skeletal muscle after cast immobilization.
Journal of applied physiology (Bethesda, Md. : 1985). 98(1):307-14 [PMID] 15333614.
2005
Fluorescent nanoparticle probes for cancer imaging.
Technology in cancer research & treatment. 4(6):593-602 [PMID] 16292879.
2005
Noninvasive monitoring of gene correction in dystrophic muscle.
Magnetic resonance in medicine. 54(6):1369-76 [PMID] 16261578.
2005
Noninvasive monitoring of muscle damage during reloading following limb disuse.
Muscle & nerve. 32(5):605-12 [PMID] 16003743.
2005
Rapid and effective labeling of brain tissue using TAT-conjugated CdS:Mn/ZnS quantum dots.
Chemical communications (Cambridge, England). (25):3144-6 [PMID] 15968352.
2004
Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension.
Physiological genomics. 19(3):255-61 [PMID] 15383639.
2004
Muscle adaptations with immobilization and rehabilitation after ankle fracture.
Medicine and science in sports and exercise. 36(10):1695-701 [PMID] 15595289.
2004
Non-invasive analysis of myoblast transplants in rodent cardiac muscle.
The international journal of cardiovascular imaging. 20(6):593-8 [PMID] 15856647.
2004
Noninvasive monitoring and tracking of muscle stem cell transplants.
Transplantation. 78(11):1626-33 [PMID] 15591951.
2004
Noninvasive monitoring of stem cell transfer for muscle disorders.
Magnetic resonance in medicine. 51(2):273-7 [PMID] 14755651.
2004
Resistance training improves strength and functional capacity in persons with multiple sclerosis.
Multiple sclerosis (Houndmills, Basingstoke, England). 10(6):668-74 [PMID] 15584492.
2002
Correction of the enzymatic and functional deficits in a model of Pompe disease using adeno-associated virus vectors.
Molecular therapy : the journal of the American Society of Gene Therapy. 5(5 Pt 1):571-8 [PMID] 11991748.
2002
Functional significance of gap junctional coupling in preimplantation development.
Biology of reproduction. 66(5):1403-12 [PMID] 11967204.
2002
Metabolic costs of isometric force generation and maintenance of human skeletal muscle.
American journal of physiology. Endocrinology and metabolism. 282(2):E448-57 [PMID] 11788378.
2000
Noninvasive measurement of gene expression in skeletal muscle.
Proceedings of the National Academy of Sciences of the United States of America. 97(10):5151-5 [PMID] 10805778.
2000
Relationship between muscle T2* relaxation properties and metabolic state: a combined localized 31P-spectroscopy and 1H-imaging study.
European journal of applied physiology. 82(1-2):76-82 [PMID] 10879446.
1999
In vivo ATP synthesis rates in single human muscles during high intensity exercise.
The Journal of physiology. 519 Pt 3(Pt 3):901-10 [PMID] 10457099.
1999
Spectral quantitation by principal component analysis using complex singular value decomposition.
Magnetic resonance in medicine. 41(3):450-5 [PMID] 10204865.
1998
Longitudinal study of skeletal muscle adaptations during immobilization and rehabilitation.
Muscle & nerve. 21(8):1006-12 [PMID] 9655118.
1997
Noninvasive measurement of phosphocreatine recovery kinetics in single human muscles.
The American journal of physiology. 272(2 Pt 1):C525-34 [PMID] 9124295.
1997
Volumetric measurement of human calf muscle from magnetic resonance imaging.
Magma (New York, N.Y.). 5(2):93-8 [PMID] 9268071.
1996
Influence of age on cerebral recovery after deep hypothermic circulatory arrest in piglets.
The Annals of thoracic surgery. 62(1):115-22 [PMID] 8678629.
1995
Energy-rich phosphates in slow and fast human skeletal muscle.
The American journal of physiology. 268(4 Pt 1):C869-76 [PMID] 7733235.
1993
pH heterogeneity during exercise in localized spectra from single human muscles.
The American journal of physiology. 265(5 Pt 1):C1332-9 [PMID] 8238485.
1992
Contribution of skeletal muscle atrophy to exercise intolerance and altered muscle metabolism in heart failure.
Circulation. 85(4):1364-73 [PMID] 1555280.
1991
Metabolic heterogeneity in human calf muscle during maximal exercise.
Proceedings of the National Academy of Sciences of the United States of America. 88(13):5714-8 [PMID] 2062850.
1991
Studies on human porin. VI. Production and characterization of eight monoclonal mouse antibodies against the human VDAC “Porin 31HL” and their application for histotopological studies in human skeletal muscle.
Biological chemistry Hoppe-Seyler. 372(12):1027-34 [PMID] 1724155.
1984
[Myocardial changes in acute pulmonary artery embolism–an experimental study].
Fortschritte der Medizin. 102(9):221-4 [PMID] 6706278.

Grants

Oct 2023 ACTIVE
The Healthy Longevity Global Competition Catalyst Award
Role: Co-Project Director/Principal Investigator
Funding: NATIONAL ACADEMY OF MEDICINE
Apr 2023 ACTIVE
Trial Readiness and Endpoint Assessment in LGMDR1 (TREATing-LGMDR1)
Role: Principal Investigator
Funding: VA COMMONWEALTH UNIV via NATL INST OF HLTH NINDS
Jan 2023 ACTIVE
National High Magnetic Field Laboratory Renewal 2023-2027
Role: Faculty
Funding: FL STATE UNIV via NATL SCIENCE FOU
Oct 2021 ACTIVE
Protein Mapping Project
Role: Co-Investigator
Funding: PARENT PROJECT MUSCULAR DYSTROPHY
Sep 2021 ACTIVE
MR Biomarkers of Bone Quality in DMD
Role: Co-Investigator
Funding: US ARMY MED RES ACQUISITION
Sep 2021 ACTIVE
Magnetic resonance biomarkers of muscle degeneration in patients with rotator cuff tears
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Aug 2021 ACTIVE
Understanding and Improving Therapies for the Muscular Dystrophies
Role: Other
Funding: NATL INST OF HLTH NIAMS
Jul 2021 – Jun 2023
Seven tesla preclinical MRI/S scanner for structural, functional and molecular imaging
Role: Other
Funding: NATL INST OF HLTH OD
May 2021 ACTIVE
Ursolic acid as a countermeasure to cancer cachexia
Role: Other
Funding: FL DEPT OF HLTH BANKHEAD-COLEY CANCER RE
Sep 2020 ACTIVE
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Aug 2020 ACTIVE
Development of MRI, Alternative Splicing, and Functional Abilities as Biomarkers in Myotonic Dystrophy Type 1
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Jul 2020 – Jun 2023
OR_DRPD_ROF2020:The Role of Trim63 in Cancer Cachexia
Role: Co-Investigator
Funding: UF RESEARCH
Jan 2018 – Dec 2023
National High Magnetic Field Laboratory Renewal 2018-2022
Role: Co-Investigator
Funding: FL STATE UNIV via NATL SCIENCE FOU
Sep 2017 – Aug 2023
FoxO signaling and skeletal muscle atrophy
Role: Project Manager
Funding: NATL INST OF HLTH NIAMS
Dec 2016 ACTIVE
UF PASS: Regulation of exercise transducers
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Sep 2016 – Jul 2022
MR Assessment of Bioenergetics and Microvascular Function in Dystrophic Muscle
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Jun 2016 – Aug 2018
Development of Magnetic Resonance Imaging as an Endpoint in Myotonic Dystrophy Type 1
Role: Co-Investigator
Funding: WYCK FOUNDATION via MYOTONIC DYSTROPHY FOU
Sep 2015 – Jul 2021
Phase II Study of AAV9-GAA Gene Transfer in Pompe Disease
Role: Project Manager
Funding: NATL INST OF HLTH NHLBI
Sep 2015 – Sep 2020
Magnetic Resonance Imaging and Biomarkers for Muscular Dystrophy
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Aug 2015 – Jul 2021
Failed Regeneration in the Muscular Dystrophies: Inflammation, Fibrosis and Fat
Role: Co-Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2014 – Jun 2018
Development of a Strength Training Protocol in Duchenne Muscular Dystrophy
Role: Project Manager
Funding: NATL INST OF HLTH NIAMS
Sep 2013 – Aug 2018
The relationship between genomic variants and MRI/MRS markers in DMD
Role: Principal Investigator
Funding: NATL INST OF HLTH NIAMS
Sep 2013 – Aug 2019
Southeast Resource Center for Integrated Metabolomics (SECIM)
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jan 2013 – Dec 2018
National High Magnetic Field Laboratory
Role: Co-Investigator
Funding: FL STATE UNIV via NATL SCIENCE FOU
Sep 2012 – Sep 2017
MD110050 Optical Imaging of Dystrophic and Damaged Muscle
Role: Principal Investigator
Funding: US DEPT OF DEFENSE
Mar 2011 – Feb 2017
CVD Protection Mechanism involving ACE2/ANG-(1-7) Axis
Role: Project Manager
Funding: NATL INST OF HLTH

Contact Details

Emails:
Business:
glennw@ufl.edu
Addresses:
Business Mailing:
PO Box 100274
GAINESVILLE FL 32610
Business Street:
PO Box 100274
GAINESVILLE FL 32610