Elaine M Sumners

Elaine M Sumners,

RES AST SCTST

Department: MD-PHYSIOLOGY FUNCTIONAL GENOM
Business Phone: (352) 294-0440
Business Email: esumners@cop.ufl.edu

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-1357-7410

Publications

2022
Efficacy and Safety of MSC Cell Therapies for Hospitalized Patients with COVID-19: A Systematic Review and Meta-Analysis.
Stem cells translational medicine. 11(7):688-703 [DOI] 10.1093/stcltm/szac032. [PMID] 35640138.
2022
Fecal matter transplant from Ace2 overexpressing mice counteracts chronic hypoxia-induced pulmonary hypertension.
Pulmonary circulation. 12(1) [DOI] 10.1002/pul2.12015. [PMID] 35506083.
2022
Gut Microbiome and Neuroinflammation in Hypertension
Circulation Research. 130(3):401-417 [DOI] 10.1161/circresaha.121.319816.
2022
Identification of a Gut Commensal That Compromises the Blood Pressure-Lowering Effect of Ester Angiotensin-Converting Enzyme Inhibitors
Hypertension. 79(8):1591-1601 [DOI] 10.1161/hypertensionaha.121.18711.
2021
Angiotensin-converting enzyme 2 and COVID-19 in cardiorenal diseases.
Clinical science (London, England : 1979). 135(1):1-17 [DOI] 10.1042/CS20200482. [PMID] 33399851.
2021
Butyrate Regulates COVID-19-Relevant Genes in Gut Epithelial Organoids From Normotensive Rats.
Hypertension (Dallas, Tex. : 1979). 77(2):e13-e16 [DOI] 10.1161/HYPERTENSIONAHA.120.16647. [PMID] 33439735.
2021
Depressive hypertension: A proposed human endotype of brain/gut microbiome dysbiosis.
American heart journal. 239:27-37 [DOI] 10.1016/j.ahj.2021.05.002. [PMID] 33984318.
2021
Distinct Gene Expression Profiles in Colonic Organoids from Normotensive and the Spontaneously Hypertensive Rats
Cells. 10(6) [DOI] 10.3390/cells10061523. [PMID] 34204247.
2021
Gut-brain-bone marrow axis in hypertension.
Current opinion in nephrology and hypertension. 30(2):159-165 [DOI] 10.1097/MNH.0000000000000678. [PMID] 33394733.
2021
Potential of Minocycline for Treatment of Resistant Hypertension.
The American journal of cardiology. 156:147-149 [DOI] 10.1016/j.amjcard.2021.07.004. [PMID] 34348841.
2020
ACE2 (Angiotensin-Converting Enzyme 2) in Cardiopulmonary Diseases: Ramifications for the Control of SARS-CoV-2.
Hypertension (Dallas, Tex. : 1979). 76(3):651-661 [DOI] 10.1161/HYPERTENSIONAHA.120.15595. [PMID] 32783758.
2020
ACE2 as therapeutic agent.
Clinical science (London, England : 1979). 134(19):2581-2595 [DOI] 10.1042/CS20200570. [PMID] 33063820.
2020
Altered Gut Microbiome Profile in Patients With Pulmonary Arterial Hypertension.
Hypertension (Dallas, Tex. : 1979). 75(4):1063-1071 [DOI] 10.1161/HYPERTENSIONAHA.119.14294. [PMID] 32088998.
2020
Fetal ovine skeletal and cardiac muscle transcriptomics are differentially altered by increased maternal cortisol during gestation.
Physiological genomics. 52(4):178-190 [DOI] 10.1152/physiolgenomics.00096.2019. [PMID] 32116114.
2020
Gut Pathology and Its Rescue by ACE2 (Angiotensin-Converting Enzyme 2) in Hypoxia-Induced Pulmonary Hypertension.
Hypertension (Dallas, Tex. : 1979). 76(1):206-216 [DOI] 10.1161/HYPERTENSIONAHA.120.14931. [PMID] 32418496.
2020
Maternal Treatment With Captopril Persistently Alters Gut-Brain Communication and Attenuates Hypertension of Male Offspring.
Hypertension (Dallas, Tex. : 1979). 75(5):1315-1324 [DOI] 10.1161/HYPERTENSIONAHA.120.14736. [PMID] 32200676.
2020
Pulmonary arterial hypertension-associated changes in gut pathology and microbiota.
ERJ open research. 6(3) [DOI] 10.1183/23120541.00253-2019. [PMID] 32743008.
2020
Pulmonary hypertension: Pathophysiology beyond the lung.
Pharmacological research. 151 [DOI] 10.1016/j.phrs.2019.104518. [PMID] 31730803.
2020
SARS-CoV-2 Receptor ACE2 (Angiotensin-Converting Enzyme 2) Is Upregulated in Colonic Organoids From Hypertensive Rats.
Hypertension (Dallas, Tex. : 1979). 76(3):e26-e28 [DOI] 10.1161/HYPERTENSIONAHA.120.15725. [PMID] 32643416.
2020
Therapeutic Delivery of Ang(1-7) via Genetically Modified Probiotic: A Dosing Study.
The journals of gerontology. Series A, Biological sciences and medical sciences. 75(7):1299-1303 [DOI] 10.1093/gerona/glz222. [PMID] 31586210.
2020
Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats.
Physiological genomics. 52(3):121-132 [DOI] 10.1152/physiolgenomics.00087.2019. [PMID] 31869283.
2020
Would Repurposing Minocycline Alleviate Neurologic Manifestations of COVID-19?
Frontiers in neuroscience. 14 [DOI] 10.3389/fnins.2020.577780. [PMID] 33117121.
2019
A Transcriptomic Model of Postnatal Cardiac Effects of Prenatal Maternal Cortisol Excess in Sheep.
Frontiers in physiology. 10 [DOI] 10.3389/fphys.2019.00816. [PMID] 31333485.
2019
Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension.
Circulation research. 125(1):104-116 [DOI] 10.1161/CIRCRESAHA.119.313965. [PMID] 31219753.
2019
Mechanisms of in utero cortisol effects on the newborn heart revealed by transcriptomic modeling.
American journal of physiology. Regulatory, integrative and comparative physiology. 316(4):R323-R337 [DOI] 10.1152/ajpregu.00322.2018. [PMID] 30624972.
2019
Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension.
Circulation research. 124(5):727-736 [DOI] 10.1161/CIRCRESAHA.118.313882. [PMID] 30612527.
2019
Sustained Captopril-Induced Reduction in Blood Pressure Is Associated With Alterations in Gut-Brain Axis in the Spontaneously Hypertensive Rat.
Journal of the American Heart Association. 8(4) [DOI] 10.1161/JAHA.118.010721. [PMID] 30755073.
2019
Transcriptomic evidence that cortisol alters perinatal epicardial adipose tissue maturation.
American journal of physiology. Endocrinology and metabolism. 317(4):E573-E585 [DOI] 10.1152/ajpendo.00007.2019. [PMID] 31322429.
2018
ACE2 and pACE2: A Pair of Aces for Pulmonary Arterial Hypertension Treatment?
American journal of respiratory and critical care medicine. 198(4):422-423 [DOI] 10.1164/rccm.201803-0569ED. [PMID] 29634285.
2018
Gut microbiota and serum metabolite differences in African Americans and White Americans with high blood pressure.
International journal of cardiology. 271:336-339 [DOI] 10.1016/j.ijcard.2018.04.074. [PMID] 30049487.
2018
Imbalance of gut microbiome and intestinal epithelial barrier dysfunction in patients with high blood pressure.
Clinical science (London, England : 1979). 132(6):701-718 [DOI] 10.1042/CS20180087. [PMID] 29507058.
2018
Increased human intestinal barrier permeability plasma biomarkers zonulin and FABP2 correlated with plasma LPS and altered gut microbiome in anxiety or depression.
Gut. 67(8):1555-1557 [DOI] 10.1136/gutjnl-2017-314759. [PMID] 28814485.
2018
Involvement of Microglial Cells in Hypoxia-induced Pulmonary Hypertension.
American journal of respiratory cell and molecular biology. 59(2):271-273 [DOI] 10.1165/rcmb.2018-0042LE. [PMID] 30067089.
2018
Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension.
Hypertension (Dallas, Tex. : 1979). 71(6):1156-1163 [DOI] 10.1161/HYPERTENSIONAHA.118.10934. [PMID] 29712738.
2018
Ketamine Reduces Inflammation Pathways in the Hypothalamus and Hippocampus Following Transient Hypoxia in the Late-Gestation Fetal Sheep.
Frontiers in physiology. 9 [DOI] 10.3389/fphys.2018.01858. [PMID] 30666211.
2018
The gut microbiota and the brain-gut-kidney axis in hypertension and chronic kidney disease.
Nature reviews. Nephrology. 14(7):442-456 [DOI] 10.1038/s41581-018-0018-2. [PMID] 29760448.
2017
Gut Microbiota: Potential for a Unifying Hypothesis for Prevention and Treatment of Hypertension.
Circulation research. 120(11):1724-1726 [DOI] 10.1161/CIRCRESAHA.117.310734. [PMID] 28546357.
2017
Intestinal Permeability Biomarker Zonulin is Elevated in Healthy Aging.
Journal of the American Medical Directors Association. 18(9):810.e1-810.e4 [DOI] 10.1016/j.jamda.2017.05.018. [PMID] 28676292.
2017
Post-hypoxia Invasion of the fetal brain by multidrug resistant Staphylococcus.
Scientific reports. 7(1) [DOI] 10.1038/s41598-017-06789-6. [PMID] 28743956.
2017
The Gut, Its Microbiome, and Hypertension.
Current hypertension reports. 19(4) [DOI] 10.1007/s11906-017-0734-1. [PMID] 28444579.
2016
Genomic Effect of Triclosan on the Fetal Hypothalamus: Evidence for Altered Neuropeptide Regulation.
Endocrinology. 157(7):2686-97 [DOI] 10.1210/en.2016-1080. [PMID] 27145008.
2016
Ketamine decreases inflammatory and immune pathways after transient hypoxia in late gestation fetal cerebral cortex.
Physiological reports. 4(6) [DOI] 10.14814/phy2.12741. [PMID] 27033443.
2016
Ketamine suppresses hypoxia-induced inflammatory responses in the late-gestation ovine fetal kidney cortex.
The Journal of physiology. 594(5):1295-310 [DOI] 10.1113/JP271066. [PMID] 26497972.
2016
Transcriptomics Modeling of the Late-Gestation Fetal Pituitary Response to Transient Hypoxia.
PloS one. 11(2) [DOI] 10.1371/journal.pone.0148465. [PMID] 26859870.
2015
Increased maternal nighttime cortisol concentrations in late gestation alter glucose and insulin in the neonatal lamb.
Physiological reports. 3(9) [DOI] 10.14814/phy2.12548. [PMID] 26371232.
2015
Patterns of gene expression in the sheep heart during the perinatal period revealed by transcriptomic modeling.
Physiological genomics. 47(9):407-19 [DOI] 10.1152/physiolgenomics.00027.2015. [PMID] 26126790.
2014
Elevated maternal cortisol leads to relative maternal hyperglycemia and increased stillbirth in ovine pregnancy.
American journal of physiology. Regulatory, integrative and comparative physiology. 307(4):R405-13 [DOI] 10.1152/ajpregu.00530.2013. [PMID] 24920731.
2014
Mechanisms for the adverse effects of late gestational increases in maternal cortisol on the heart revealed by transcriptomic analyses of the fetal septum.
Physiological genomics. 46(15):547-59 [DOI] 10.1152/physiolgenomics.00009.2014. [PMID] 24867915.
2014
Mineralocorticoid effects in the late gestation ovine fetal lung.
Physiological reports. 2(7) [DOI] 10.14814/phy2.12066. [PMID] 25347852.
2014
Transcriptomics of the fetal hypothalamic response to brachiocephalic occlusion and estradiol treatment.
Physiological genomics. 46(14):523-32 [DOI] 10.1152/physiolgenomics.00186.2013. [PMID] 24824211.
2013
Cortisol stimulates proliferation and apoptosis in the late gestation fetal heart: differential effects of mineralocorticoid and glucocorticoid receptors.
American journal of physiology. Regulatory, integrative and comparative physiology. 305(4):R343-50 [DOI] 10.1152/ajpregu.00112.2013. [PMID] 23785077.
2013
Genomics of the fetal hypothalamic cellular response to transient hypoxia: endocrine, immune, and metabolic responses.
Physiological genomics. 45(13):521-7 [DOI] 10.1152/physiolgenomics.00005.2013. [PMID] 23653468.
2012
Genomics of estradiol-3-sulfate action in the ovine fetal hypothalamus.
Physiological genomics. 44(13):669-77 [DOI] 10.1152/physiolgenomics.00127.2011. [PMID] 22570439.
2012
Serotonergic effects on feeding, but not hypothalamus-pituitary-adrenal secretion, are altered in ovine pregnancy.
American journal of physiology. Endocrinology and metabolism. 302(10):E1231-8 [DOI] 10.1152/ajpendo.00582.2011. [PMID] 22374755.
2011
Differential effects of mineralocorticoid blockade on the hypothalamo-pituitary-adrenal axis in pregnant and nonpregnant ewes.
American journal of physiology. Endocrinology and metabolism. 300(3):E592-9 [DOI] 10.1152/ajpendo.00560.2010. [PMID] 21205934.
2009
Expression of ENaC subunits, chloride channels, and aquaporins in ovine fetal lung: ontogeny of expression and effects of altered fetal cortisol concentrations.
American journal of physiology. Regulatory, integrative and comparative physiology. 297(2):R453-61 [DOI] 10.1152/ajpregu.00127.2009. [PMID] 19515987.
2003
Pharmacology and physiology of ovine corticosteroid receptors.
Neuroendocrinology. 77(1):2-14 [PMID] 12624536.
1999
Angiotensin II type 1 receptor-modulated signaling pathways in neurons.
Molecular neurobiology. 19(1):25-41 [PMID] 10321970.
1999
Angiotensin II type 2 receptor-mediated apoptosis of cultured neurons from newborn rat brain.
Endocrinology. 140(1):500-9 [PMID] 9886863.
1999
Prostaglandin endoperoxide synthase-2 abundance is increased in brain tissues of late-gestation fetal sheep in response to cerebral hypoperfusion
J Soc Gynecol Investig.. 6(3):127-135
1998
Regulation of alpha2A-adrenergic receptor expression by epinephrine in cultured astroglia from rat brain.
Journal of neurochemistry. 70(1):86-95 [PMID] 9422350.
1997
Modulation of angiotensin II type 2 receptor mRNA in rat hypothalamus and brainstem neuronal cultures by growth factors.
Brain research. Molecular brain research. 47(1-2):229-36 [PMID] 9221921.
1997
Regulation of alpha 2A-adrenergic receptor mRNA in rat astroglial cultures: role of cyclic AMP and protein kinase C.
Journal of neurochemistry. 68(1):47-57 [PMID] 8978709.
1996
Angiotensin II stimulates protein phosphatase 2A activity in cultured neuronal cells via type 2 receptors in a pertussis toxin sensitive fashion.
Advances in experimental medicine and biology. 396:209-15 [PMID] 8726701.
1996
Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors.
The Journal of biological chemistry. 271(26):15635-41 [PMID] 8663175.
1995
Angiotensin II decreases inducible nitric oxide synthase expression in rat astroglial cultures
Am J Physiol. 268(3):C700-C707
1995
Angiotensin II increases glucose uptake and glucose transporter-1 mRNA levels in astroglia.
The American journal of physiology. 268(3 Pt 1):E384-90 [PMID] 7900784.
1995
Angiotensin II type 2 receptor-mediated stimulation of protein phosphatase 2A in rat hypothalamic/brainstem neuronal cocultures.
Journal of neurochemistry. 65(5):2131-7 [PMID] 7595499.
1995
Modulation of the delayed rectifier K+ current in neurons by an angiotensin II type 2 receptor fragment.
The American journal of physiology. 268(1 Pt 1):C278-82 [PMID] 7840157.
1994
Determinants of serotype specificity in transcription of vesicular stomatitis virus synthetic nucleocapsids
Virology. 199(1):11-19
1993
Angiotensin II type 2 receptor expression in neuronal cultures from spontaneously hypertensive rat brain.
Regulatory peptides. 44(2):181-8 [PMID] 8385790.
1993
Immunohistochemical mapping of angiotensin AT1 receptors in the brain.
Regulatory peptides. 44(2):95-107 [PMID] 8469778.
1993
Inhibition of central angiotensin responses by angiotensin type-1 receptor antibody.
Hypertension (Dallas, Tex. : 1979). 21(6 Pt 2):1062-5 [PMID] 8505093.
1992
Characterization of a polyclonal anti-peptide antibody to the angiotensin II type-1 (AT1) receptor.
Biochemical and biophysical research communications. 183(2):781-8 [PMID] 1550583.
1989
Alpha 2-adrenergic receptors in neuronal and glial cultures: characterization and comparison.
Journal of neurochemistry. 53(1):287-96 [PMID] 2542464.
1989
Release of immunoreactive angiotensin II from neuronal cultures: adrenergic influences.
The American journal of physiology. 257(3 Pt 1):C588-95 [PMID] 2571298.
1982
Central pressor action of neurotensin in conscious rats.
Hypertension (Dallas, Tex. : 1979). 4(6):888-93 [PMID] 6815078.

Education

PhD
1988 · University of Florida
BSc
1979 · University of Southampton, UK

Contact Details

Phones:
Business:
(352) 294-0440
Emails:
Addresses:
Business Mailing:
PO Box 100274
GAINESVILLE FL 32610
Business Street:
1149 Newell Drive
L4-181
GAINESVILLE FL 32610