Mark S Segal

Mark S Segal, M.D., PH.D.

Senior Associate Dean For Faculty Affairs & Professional Development

Department: MD-NEPHROLOGY
Business Phone: (352) 273-8821
Business Email: segalms@medicine.ufl.edu

About Mark S Segal

I am the senior associate dean for faculty affairs and professional development for the University of Florida College of Medicine and a professor of medicine in the UF Division of Nephrology, Hypertension & Renal Transplantation. I love the long-term patient-doctor relationship and the quantitative element of nephrology. I treat patients with lupus nephritis, ANCA vasculitis, aHUS and patients who are pregnant and have kidney disease. I strive to help patient’s live long, fulfilling lives without the need of dialysis or kidney transplantation.

I received my Bachelor of Science from the Massachusetts Institute of Technology (MIT), and my MD/PhD degrees from the University of Texas Southwestern Medical School. I completed an internal medicine internship and residency at Parkland Memorial Hospital and a nephrology fellowship at Beth Israel Deaconess Medical Center in Boston. I am board certified in internal medicine and nephrology by the American Board of Internal Medicine.

My research has been funded continuously by the National Institutes of Health (NIH), and I study the mechanism of cardiovascular disease in unique patient populations. As a physician and a scientist, my goal is to remain a lifelong learner, always reassessing the best and most effective way to provide individualized care to my patients.

When not helping patients, I enjoy home renovation, gardening and cooking.

Additional Positions:
Central Florida Kidney Center, Inc. Eminent Scholar Chair in Nephrology and Hypertension
2021 – Current ·
Professor of Medicine
2014 – Current ·

Teaching Profile

Courses Taught
2019-2020,2022-2023
PAS5010 Intro to Medicine 1
2014-2023
MDU4010 Cell Biology Seminar
2018
MDC7200 Medicine Clerkship
2016
BMS4905 Medical Sciences Senior Research
2014-2016
MDT7200 Elect Top/Medicine
2015
GMS7093 Introduction to Clinical and Translational Research
2015,2024
BMS6638C Kidney & Urinary Tract
2015
GMS6683 Fundamentals of Vascular Physiology and Pathology
2006-2007,2009-2012,2012
MEL4003 Cell Biology Seminar

Board Certifications

  • Internal Medicine
    American Board of Internal Medicine
  • Nephrology
    American Board of Internal Medicine

Clinical Profile

Specialties
  • Nephrology
Areas of Interest
  • Glomerulonephritis
  • Lupus nephritis
  • Necrotizing vasculitis
  • Systemic lupus erythematosus
  • Thrombotic thrombocytopenic purpura

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-5502-2042

Publications

2024
Development and validation of a race-agnostic computable phenotype for kidney health in adult hospitalized patients.
PloS one. 19(4) [DOI] 10.1371/journal.pone.0299332. [PMID] 38652731.
2024
Ethics and Terminology for Opting In and Out.
JAMA internal medicine. 184(4):451-452 [DOI] 10.1001/jamainternmed.2023.7060. [PMID] 38372980.
2024
Mobile Electrocardiograms in the Detection of Subclinical Atrial Fibrillation in High-Risk Outpatient Populations: Protocol for an Observational Study
JMIR Research Protocols. 13 [DOI] 10.2196/52647. [PMID] 38801762.
2023
Initiative to improve the quality of patient care for chronic dialysis patients in the inpatient setting.
Hemodialysis international. International Symposium on Home Hemodialysis. 27(3):339-341 [DOI] 10.1111/hdi.13078. [PMID] 36966510.
2023
Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis.
Clinical immunology (Orlando, Fla.). 248 [DOI] 10.1016/j.clim.2022.109213. [PMID] 36566913.
2023
National Treatment Patterns and Outcomes for Hospitalized Patients with Chronic Limb-Threatening Ischemia and End-Stage Kidney Disease.
Vascular and endovascular surgery. 57(4):357-364 [DOI] 10.1177/15385744221146868. [PMID] 36541126.
2023
Organizing Nephrologists at the State Level: The Florida Experience.
Clinical journal of the American Society of Nephrology : CJASN. 18(1):124-126 [DOI] 10.2215/CJN.09430822. [PMID] 36344210.
2023
Pea hull fiber supplementation does not modulate uremic metabolites in adults receiving hemodialysis: a randomized, double-blind, controlled trial.
Frontiers in nutrition. 10 [DOI] 10.3389/fnut.2023.1179295. [PMID] 37457968.
2022
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery. 275(6):1184-1193 [DOI] 10.1097/SLA.0000000000004360. [PMID] 33196489.
2022
Early Biomarker Signatures in Surgical Sepsis.
The Journal of surgical research. 277:372-383 [DOI] 10.1016/j.jss.2022.04.052. [PMID] 35569215.
2022
EARLY DIFFERENTIATION BETWEEN SEPSIS AND STERILE INFLAMMATION VIA URINARY GENE SIGNATURES OF METABOLIC DYSREGULATION.
Shock (Augusta, Ga.). 58(1):20-27 [DOI] 10.1097/SHK.0000000000001952. [PMID] 35904146.
2022
Existing Transplant Nephrology Compensation Models and Opportunities for Equitable Pay.
Clinical journal of the American Society of Nephrology : CJASN. 17(9):1407-1409 [DOI] 10.2215/CJN.02010222. [PMID] 35914793.
2022
Provision of Kidney Disease Education Service Is Associated with Improved Vascular Access Outcomes among US Incident Hemodialysis Patients.
Kidney360. 3(1):91-98 [DOI] 10.34067/KID.0004502021. [PMID] 35368570.
2022
The Importance of Transplant Nephrology to a Successful Kidney Transplant Program.
Clinical journal of the American Society of Nephrology : CJASN. 17(9):1403-1406 [DOI] 10.2215/CJN.02000222. [PMID] 35914794.
2021
Advancing Nephrology: Division Leaders Advise ASN.
Clinical journal of the American Society of Nephrology : CJASN. 16(2):319-327 [DOI] 10.2215/CJN.01550220. [PMID] 32792352.
2021
Association of early initiation of dialysis with all-cause and cardiovascular mortality: A propensity score weighted analysis of the United States Renal Data System.
Hemodialysis international. International Symposium on Home Hemodialysis. 25(2):188-197 [DOI] 10.1111/hdi.12912. [PMID] 33644974.
2021
Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial.
JAMA neurology. [DOI] 10.1001/jamaneurol.2021.0178. [PMID] 33683313.
2021
Association of persistent acute kidney injury and renal recovery with mortality in hospitalised patients.
BMJ health & care informatics. 28(1) [DOI] 10.1136/bmjhci-2021-100458. [PMID] 34876451.
2021
Circulating endothelial cells as predictor of long-term mortality and adverse cardiovascular outcomes in hemodialysis patients.
Seminars in dialysis. 34(2):163-169 [DOI] 10.1111/sdi.12943. [PMID] 33280176.
2021
LC-MS lipidomics of renal biopsies for the diagnosis of Fabry disease.
Journal of mass spectrometry and advances in the clinical lab. 22:71-78 [DOI] 10.1016/j.jmsacl.2021.11.004. [PMID] 34918004.
2021
Management of Cardiovascular Disease in Kidney Disease Study: Rationale and Design.
American journal of nephrology. 52(1):36-44 [DOI] 10.1159/000513567. [PMID] 33640890.
2021
Nonatherosclerotic Vascular Abnormalities Associated with Chronic Kidney Disease.
Cardiology clinics. 39(3):415-425 [DOI] 10.1016/j.ccl.2021.04.012. [PMID] 34247754.
2021
Pro Re Nata Antihypertensive Medications and Adverse Outcomes in Hospitalized Patients: A Propensity-Matched Cohort Study.
Hypertension (Dallas, Tex. : 1979). 78(2):516-524 [DOI] 10.1161/HYPERTENSIONAHA.121.17279. [PMID] 34148363.
2021
Relationships between reproductive hormones and maternal pregnancy physiology in women conceiving with or without in vitro fertilization.
American journal of physiology. Regulatory, integrative and comparative physiology. 321(3):R454-R468 [DOI] 10.1152/ajpregu.00174.2020. [PMID] 34346723.
2021
Utilization of CMS pre-ESRD Kidney Disease Education services and its associations with the home dialysis therapies.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis. 41(5):453-462 [DOI] 10.1177/0896860820975586. [PMID] 33258420.
2020
A Word of Caution in the Use of Hydroxychloroquine in the Elderly COVID-19 Population.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.). 9(4):374-375 [DOI] 10.1097/APO.0000000000000314. [PMID] 32740071.
2020
Discovery and Validation of Urinary Molecular Signature of Early Sepsis.
Critical care explorations. 2(10) [DOI] 10.1097/CCE.0000000000000195. [PMID] 33063018.
2020
Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation.
Journal of colloid and interface science. 564:204-215 [DOI] 10.1016/j.jcis.2019.12.092. [PMID] 31911225.
2020
Graft-versus-host disease of the kidney.
Hematology/oncology and stem cell therapy. 13(3):178-179 [DOI] 10.1016/j.hemonc.2019.01.003. [PMID] 30807739.
2020
Maternal endothelial function, circulating endothelial cells, and endothelial progenitor cells in pregnancies conceived with or without in vitro fertilization.
American journal of physiology. Regulatory, integrative and comparative physiology. 318(6):R1091-R1102 [DOI] 10.1152/ajpregu.00015.2020. [PMID] 32349514.
2020
Roxadustat for Anemia in Patients with Chronic Kidney Disease.
The New England journal of medicine. 383(1) [DOI] 10.1056/NEJMc1913712. [PMID] 32610000.
2020
Tubular Biomarkers and Chronic Kidney Disease Progression in SPRINT Participants.
American journal of nephrology. 51(10):797-805 [DOI] 10.1159/000509978. [PMID] 32906135.
2019
Antihypertensive therapy prescribing patterns and correlates of blood pressure control among hypertensive patients with chronic kidney disease.
Journal of clinical hypertension (Greenwich, Conn.). 21(1):91-101 [DOI] 10.1111/jch.13429. [PMID] 30427124.
2019
Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum.
Hypertension (Dallas, Tex. : 1979). 73(3):640-649 [DOI] 10.1161/HYPERTENSIONAHA.118.12043. [PMID] 30636552.
2019
Integrating Point-of-Care Ultrasonography Into Nephrology Fellowship Training: A Model Curriculum.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 74(1):1-5 [DOI] 10.1053/j.ajkd.2019.02.002. [PMID] 30910369.
2019
Maternal Cardiovascular Dysregulation During Early Pregnancy After In Vitro Fertilization Cycles in the Absence of a Corpus Luteum.
Hypertension (Dallas, Tex. : 1979). 74(3):705-715 [DOI] 10.1161/HYPERTENSIONAHA.119.13015. [PMID] 31352818.
2019
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Critical care (London, England). 23(1) [DOI] 10.1186/s13054-019-2628-x. [PMID] 31722736.
2019
Opioid Safety and Concomitant Benzodiazepine Use in End-Stage Renal Disease Patients.
Pain research & management. 2019 [DOI] 10.1155/2019/3865924. [PMID] 31772694.
2019
Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women.
American journal of physiology. Endocrinology and metabolism. 317(4):E677-E685 [DOI] 10.1152/ajpendo.00225.2019. [PMID] 31408378.
2019
Serum Sodium and Pulse Pressure in SPRINT.
American journal of hypertension. 32(7):649-656 [DOI] 10.1093/ajh/hpz055. [PMID] 30977767.
2019
The utility of trough mycophenolic acid levels for the management of lupus nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 34(1):83-89 [DOI] 10.1093/ndt/gfy026. [PMID] 29548021.
2018
Activation of the β-common receptor by erythropoietin impairs acetylcholine-mediated vasodilation in mouse mesenteric arterioles.
Physiological reports. 6(12) [DOI] 10.14814/phy2.13751. [PMID] 29939494.
2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery. 84(2):342-349 [DOI] 10.1097/TA.0000000000001758. [PMID] 29251709.
2018
Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Frontiers in immunology. 9 [DOI] 10.3389/fimmu.2018.01511. [PMID] 30013565.
2018
Computational design and experimental characterization of a novel β-common receptor inhibitory peptide.
Peptides. 104:1-6 [DOI] 10.1016/j.peptides.2018.04.001. [PMID] 29635062.
2018
Development of a personalized diagnostic model for kidney stone disease tailored to acute care by integrating large clinical, demographics and laboratory data: the diagnostic acute care algorithm – kidney stones (DACA-KS).
BMC medical informatics and decision making. 18(1) [DOI] 10.1186/s12911-018-0652-4. [PMID] 30119627.
2018
Gender, blood pressure, and cardiovascular and renal outcomes in adults with hypertension from the Systolic Blood Pressure Intervention Trial.
Journal of hypertension. 36(4):904-915 [DOI] 10.1097/HJH.0000000000001619. [PMID] 29493562.
2018
Not all that is red is blood: a curious case of chromaturia.
Clinical case reports. 6(6):1179-1180 [DOI] 10.1002/ccr3.1514. [PMID] 29881591.
2018
Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.
Surgery. 164(2):178-184 [DOI] 10.1016/j.surg.2018.04.011. [PMID] 29807651.
2018
Pulse pressure, arterial stiffening, and the efficacy of renin-angiotensin system inhibitor combinations.
Journal of human hypertension. 32(2):165-166 [DOI] 10.1038/s41371-017-0014-1. [PMID] 29230003.
2018
Wave reflections and global arterial compliance during normal human pregnancy.
Physiological reports. 6(24) [DOI] 10.14814/phy2.13947. [PMID] 30578623.
2017
Case Report of Spontaneous Remission of Biopsy-Proven Idiopathic Immune Complex-Mediated Membranoproliferative Glomerulonephritis.
Case reports in nephrology and dialysis. 7(2):81-90 [DOI] 10.1159/000477660. [PMID] 28868298.
2017
Comparison of multiple non-invasive methods of measuring cardiac output during pregnancy reveals marked heterogeneity in the magnitude of cardiac output change between women.
Physiological reports. 5(8) [DOI] 10.14814/phy2.13223. [PMID] 28438984.
2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open. 7(7) [DOI] 10.1136/bmjopen-2016-015136. [PMID] 28765125.
2017
Tubulointerstitial Nephritis in Sjögren Syndrome Treated With Mycophenolate Mofetil.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases. 23(7):402-403 [DOI] 10.1097/RHU.0000000000000595. [PMID] 28937480.
2017
Using Organizational Philosophy to Create a Self-Sustaining Compensation Plan Without Harming Academic Missions.
Academic medicine : journal of the Association of American Medical Colleges. 92(8):1133-1137 [DOI] 10.1097/ACM.0000000000001484. [PMID] 28746136.
2016
A case of isolated renal involvement of polyarteritis nodosa successfully treated with steroid monotherapy.
BMJ case reports. 2016 [DOI] 10.1136/bcr-2016-215702. [PMID] 27440849.
2016
A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.). 68(12):2917-2928 [DOI] 10.1002/art.39781. [PMID] 27274010.
2016
Acute and Chronic Kidney Disease and Cardiovascular Mortality After Major Surgery.
Annals of surgery. 264(6):987-996 [PMID] 26756753.
2016
Effects of Long-Term Type I Interferon on the Arterial Wall and Smooth Muscle Progenitor Cells Differentiation.
Arteriosclerosis, thrombosis, and vascular biology. 36(2):266-73 [DOI] 10.1161/ATVBAHA.115.306767. [PMID] 26634654.
2016
Nebivolol Effects on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients.
Journal of clinical hypertension (Greenwich, Conn.). 18(8):741-9 [DOI] 10.1111/jch.12745. [PMID] 26692375.
2015
Cost and Mortality Associated With Postoperative Acute Kidney Injury.
Annals of surgery. 261(6):1207-14 [DOI] 10.1097/SLA.0000000000000732. [PMID] 24887982.
2015
DNA Aptamer Assembly as a Vascular Endothelial Growth Factor Receptor Agonist.
Nucleic acid therapeutics. 25(5):227-34 [DOI] 10.1089/nat.2014.0519. [PMID] 26125598.
2015
Fiber supplementation lowers plasma p-cresol in chronic kidney disease patients.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 25(3):316-20 [DOI] 10.1053/j.jrn.2014.09.002. [PMID] 25446837.
2015
Heart failure and chronic kidney disease: should we use spironolactone?
The American journal of the medical sciences. 350(2):147-51 [DOI] 10.1097/MAJ.0000000000000514. [PMID] 26086152.
2015
Higher levels of adiponectin in vascular endothelial cells are associated with greater brachial artery flow-mediated dilation in older adults.
Experimental gerontology. 63:1-7 [DOI] 10.1016/j.exger.2014.12.018. [PMID] 25572013.
2015
Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease.
PloS one. 10(9) [DOI] 10.1371/journal.pone.0139226. [PMID] 26414017.
2015
Mild renal dysfunction and long-term adverse outcomes in women with chest pain: results from the National Heart, Lung, and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
American heart journal. 169(3):412-8 [DOI] 10.1016/j.ahj.2014.12.010. [PMID] 25728732.
2015
Renal function and coronary microvascular dysfunction in women with symptoms/signs of ischemia.
PloS one. 10(5) [DOI] 10.1371/journal.pone.0125374. [PMID] 25951606.
2015
The effect of the addition of allopurinol on blood pressure control in African Americans treated with a thiazide-like diuretic.
Journal of the American Society of Hypertension : JASH. 9(8):610-619.e1 [DOI] 10.1016/j.jash.2015.05.009. [PMID] 26140739.
2014
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.
Arthritis & rheumatology (Hoboken, N.J.). 66(2):390-6 [DOI] 10.1002/art.38220. [PMID] 24504811.
2014
Uric acid inhibition of dipeptidyl peptidase IV in vitro is dependent on the intracellular formation of triuret.
Experimental cell research. 326(1):136-42 [DOI] 10.1016/j.yexcr.2014.05.025. [PMID] 24925478.
2014
Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms.
PloS one. 9(4) [DOI] 10.1371/journal.pone.0093965. [PMID] 24713821.
2013
Evaluation of stability and sensitivity of cell fluorescent labels when used for cell migration.
Journal of fluorescence. 23(5):975-87 [DOI] 10.1007/s10895-013-1224-8. [PMID] 23722994.
2013
Foods with added fiber lower serum creatinine levels in patients with chronic kidney disease.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation. 23(2):e29-32 [DOI] 10.1053/j.jrn.2012.04.002. [PMID] 22739658.
2013
Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model.
Diabetologia. 56(3):644-53 [DOI] 10.1007/s00125-012-2781-0. [PMID] 23192694.
2013
Lupus nephritis and end-stage kidney disease.
The American journal of the medical sciences. 346(4):319-23 [DOI] 10.1097/MAJ.0b013e31827f4ee3. [PMID] 23370533.
2013
Mineralocorticoid receptors modulate vascular endothelial function in human obesity.
Clinical science (London, England : 1979). 125(11):513-20 [DOI] 10.1042/CS20130200. [PMID] 23786536.
2013
National surgical quality improvement program underestimates the risk associated with mild and moderate postoperative acute kidney injury.
Critical care medicine. 41(11):2570-83 [DOI] 10.1097/CCM.0b013e31829860fc. [PMID] 23928835.
2013
Number and function of bone-marrow derived angiogenic cells and coronary flow reserve in women without obstructive coronary artery disease: a substudy of the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
PloS one. 8(12) [DOI] 10.1371/journal.pone.0081595. [PMID] 24312563.
2013
Racial and socioeconomic disparities in the allocation of expanded criteria donor kidneys.
Clinical journal of the American Society of Nephrology : CJASN. 8(12):2158-64 [DOI] 10.2215/CJN.01430213. [PMID] 24115196.
2013
The role of uric acid in the pathogenesis of human cardiovascular disease.
Heart (British Cardiac Society). 99(11):759-66 [DOI] 10.1136/heartjnl-2012-302535. [PMID] 23343689.
2012
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects.
Metabolism: clinical and experimental. 61(5):641-51 [DOI] 10.1016/j.metabol.2011.09.013. [PMID] 22152650.
2012
Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children’s Oncology Group.
International journal of molecular imaging. 2012 [DOI] 10.1155/2012/250834. [PMID] 23050139.
2012
Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.
Blood. 119(2):629-36 [DOI] 10.1182/blood-2011-04-346007. [PMID] 22028476.
2011
Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients.
Clinical lung cancer. 12(4):237-44 [DOI] 10.1016/j.cllc.2011.03.025. [PMID] 21726823.
2011
Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.
Arthritis research & therapy. 13(3) [DOI] 10.1186/ar3334. [PMID] 21569292.
2011
Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide.
Endocrinology. 152(7):2786-96 [DOI] 10.1210/en.2010-1126. [PMID] 21558316.
2011
Screening prevalence and incidence of colorectal cancer among American Indian/Alaskan natives in the Indian Health Service.
Digestive diseases and sciences. 56(7):2104-13 [DOI] 10.1007/s10620-010-1528-3. [PMID] 21234688.
2011
The relative importance of predictors of body mass index change, overweight and obesity in adolescent girls.
International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity. 6(2-2):e233-42 [DOI] 10.3109/17477166.2010.545410. [PMID] 21244233.
2010
Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.
Journal of neuroimmunology. 223(1-2):13-9 [DOI] 10.1016/j.jneuroim.2010.03.018. [PMID] 20416954.
2010
Endothelial progenitor cells and endothelial vesicles – what is the significance for patients with chronic kidney disease?
Blood purification. 29(2):158-62 [DOI] 10.1159/000245643. [PMID] 20093822.
2010
Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2.
Blood. 115(4):896-905 [DOI] 10.1182/blood-2009-04-216432. [PMID] 19965681.
2010
Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis research & therapy. 12(3) [DOI] 10.1186/ar3017. [PMID] 20478071.
2010
Uric acid and hypertension: cause or effect?
Current rheumatology reports. 12(2):108-17 [DOI] 10.1007/s11926-010-0094-1. [PMID] 20425019.
2009
Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery.
Circulation. 119(18):2444-53 [DOI] 10.1161/CIRCULATIONAHA.108.800011. [PMID] 19398670.
2009
Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis.
The Journal of rheumatology. 36(12):2682-90 [DOI] 10.3899/jrheum.090338. [PMID] 19884269.
2009
Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock.
The Journal of experimental medicine. 206(13):2897-906 [DOI] 10.1084/jem.20090889. [PMID] 19934019.
2009
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
Endocrine reviews. 30(1):96-116 [DOI] 10.1210/er.2008-0033. [PMID] 19151107.
2009
Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.
Arthritis research & therapy. 11(1) [DOI] 10.1186/ar2590. [PMID] 19144150.
2009
Lambda chops: creation of site-directed mutants in insertable fragments utilizing Gateway technology.
Molecular biotechnology. 42(3):275-81 [DOI] 10.1007/s12033-009-9158-8. [PMID] 19301156.
2009
Long-term risk of mortality and acute kidney injury during hospitalization after major surgery.
Annals of surgery. 249(5):851-8 [DOI] 10.1097/SLA.0b013e3181a40a0b. [PMID] 19387314.
2009
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
The American journal of pathology. 174(4):1221-9 [DOI] 10.2353/ajpath.2009.080605. [PMID] 19246639.
2009
Role of relaxin in maternal systemic and renal vascular adaptations during gestation.
Annals of the New York Academy of Sciences. 1160:304-12 [DOI] 10.1111/j.1749-6632.2009.03829.x. [PMID] 19416209.
2009
Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 877(1-2):65-70 [DOI] 10.1016/j.jchromb.2008.11.029. [PMID] 19081307.
2009
Urinary CD80 excretion increases in idiopathic minimal-change disease.
Journal of the American Society of Nephrology : JASN. 20(2):260-6 [DOI] 10.1681/ASN.2007080836. [PMID] 19056875.
2008
Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes.
Diabetes. 57(9):2488-94 [DOI] 10.2337/db08-0381. [PMID] 18559661.
2008
How safe is fructose for persons with or without diabetes?
The American journal of clinical nutrition. 88(5):1189-90 [PMID] 18996851.
2008
Long-term engraftment of bone marrow-derived cells in the intimal hyperplasia lesion of autologous vein grafts.
The American journal of pathology. 172(3):839-48 [DOI] 10.2353/ajpath.2008.070840. [PMID] 18276778.
2008
Tacrolimus rescue therapy in resistant or relapsing cases of primary glomerulonephritis.
Journal of nephrology. 21(5):713-21 [PMID] 18949726.
2007
A breakthrough in diabetic nephropathy: the role of endothelial dysfunction.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 22(10):2775-7 [PMID] 17595179.
2007
Autoantibodies to RNA helicase A: a new serologic marker of early lupus.
Arthritis and rheumatism. 56(2):596-604 [PMID] 17265494.
2007
Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?
European journal of nutrition. 46(7):406-17 [PMID] 17763967.
2007
Mitomycin- and calcineurin-associated HUS, endothelial dysfunction and endothelial repair: a new paradigm for the puzzle?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 22(2):617-20 [PMID] 17041000.
2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
The American journal of clinical nutrition. 86(4):899-906 [PMID] 17921363.
2007
Retinal and choroidal microangiopathies: therapeutic opportunities.
Microvascular research. 74(2-3):131-44 [PMID] 17585951.
2007
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Arthritis and rheumatism. 56(11):3759-69 [PMID] 17968925.
2007
Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2′-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress.
Journal of chromatography. A. 1167(1):54-62 [PMID] 17765254.
2006
A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome.
Pediatric nephrology (Berlin, Germany). 21(5):603-10 [PMID] 16525836.
2006
Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases.
Arthritis research & therapy. 8(4) [PMID] 16846524.
2006
Endothelial health and diversity in the kidney.
Journal of the American Society of Nephrology : JASN. 17(2):323-4 [PMID] 16434502.
2006
Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes.
Diabetes. 55(1):102-9 [PMID] 16380482.
2006
Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.
Vaccine. 24(19):4035-40 [PMID] 16464519.
2006
Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular disease.
Kidney international. 69(10):1722-5 [PMID] 16598194.
2006
Urinary biomarkers in lupus nephritis.
Autoimmunity reviews. 5(6):383-8 [PMID] 16890891.
2005
A novel mouse model of autologous venous graft intimal hyperplasia.
The Journal of surgical research. 126(1):106-13 [PMID] 15916983.
2005
Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.). 117(3):238-50 [PMID] 16126005.
2005
Circulating endothelial cells are associated with future vascular events in hemodialysis patients.
Kidney international. 67(3):1078-83 [PMID] 15698448.
2005
Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
Journal of the American Society of Nephrology : JASN. 16(7):1909-19 [PMID] 15843466.
2005
High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk.
Lupus. 14(8):576-82 [PMID] 16175928.
2005
SDF-1 is both necessary and sufficient to promote proliferative retinopathy.
The Journal of clinical investigation. 115(1):86-93 [PMID] 15630447.
2004
Diuretic-induced hyperuricemia does not decrease cardiovascular risk.
Journal of hypertension. 22(7):1415-7; author reply 1417 [PMID] 15201561.
2004
Management and outcomes of care of fever in early infancy.
JAMA. 291(10):1203-12 [PMID] 15010441.
2004
Real-time analysis of apoptosis in vivo.
Methods in cell biology. 75:343-54 [PMID] 15603432.
2004
Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis.
Arthritis and rheumatism. 50(6):1842-9 [PMID] 15188361.
2004
The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation.
American journal of physiology. Cell physiology. 287(3):C664-72 [PMID] 15128503.
2004
Thrombotic microangiopathy associated with unusual viral sequences in HIV-1-positive patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 19(5):1129-35 [PMID] 14993479.
2004
Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone.
Archives of ophthalmology (Chicago, Ill. : 1960). 122(12):1801-7 [PMID] 15596583.
2003
Circulating endothelial cells as potential markers of the state of the endothelium in hemodialysis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 42(4):704-12 [PMID] 14520620.
2003
Factors associated with future amputation among patients undergoing hemodialysis: results from the Dialysis Morbidity and Mortality Study Waves 3 and 4.
American journal of kidney diseases : the official journal of the National Kidney Foundation. 41(1):162-70 [PMID] 12500233.
2003
Intimal exuberance: veins in jeopardy.
The American journal of pathology. 162(6):1759-61 [PMID] 12759233.
2002
Air pollution and hospital admissions for ischemic heart disease in persons with congestive heart failure or arrhythmia.
Environmental health perspectives. 110(12):1247-52 [PMID] 12460805.
2002
Circulating endothelial cells: tea leaves for renal disease.
American journal of physiology. Renal physiology. 283(1):F11-9 [PMID] 12060582.
2002
Marker for real-time analysis of caspase activity in intact cells.
BioTechniques. 33(6):1284-7, 1289 [PMID] 12503313.
2002
Regulation of plasminogen activator inhibitor (PAI)-1 expression in a human trophoblast cell line by glucocorticoid (GC) and transforming growth factor (TGF)-beta.
Placenta. 23(10):727-34 [PMID] 12398812.
2001
Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity.
American journal of physiology. Cell physiology. 281(4):C1196-204 [PMID] 11546656.
1999
Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin.
Biochemical and biophysical research communications. 255(3):735-9 [PMID] 10049780.
1999
Endostatin induces endothelial cell apoptosis.
The Journal of biological chemistry. 274(17):11721-6 [PMID] 10206987.
1999
Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells.
Biochemical and biophysical research communications. 258(3):668-73 [PMID] 10329443.
1996
Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro.
Mechanisms of development. 59(1):89-102 [PMID] 8892235.
1993
Age-related cognitive deficits in rats are associated with a combined loss of cholinergic and serotonergic functions.
Annals of the New York Academy of Sciences. 695:254-7 [PMID] 8239292.
1992
Disulfide bond formation during the folding of influenza virus hemagglutinin.
The Journal of cell biology. 118(2):227-44 [PMID] 1321156.
1992
Serum beta 2-microglobulin and prediction of progression to AIDS in HIV infection.
Lancet (London, England). 339(8807):1436-40 [PMID] 1351128.
1991
A comparison of black and white family caregivers experience with dementia.
Journal of National Black Nurses' Association : JNBNA. 5(1):29-41 [PMID] 1885954.
1990
The influence of oral potassium chloride on blood pressure in hypertensive men on a low-sodium diet.
The New England journal of medicine. 322(9):569-74 [PMID] 2406601.
1975
Isoproterenol aerosols.
Annals of allergy. 34(4):205-9 [PMID] 1124859.
1964
CHRONIC BRONCHITIS.
The New England journal of medicine. 270:894-7 CONTD [PMID] 14112454.

Grants

Dec 2023 ACTIVE
A LONG-TERM FOLLOW-UP STUDY OF PARTICIPANTS EXPOSED TO RENAL AUTOLOGOUS CELL THERAPY (REACT) FROM STUDIES RMCL-002, REGEN-003, REGEN-004
Role: Principal Investigator
Funding: PROKIDNEY
Jul 2023 ACTIVE
Together: Transforming and Translating Discovery to Improve Health
Role: Faculty
Funding: NATL INST OF HLTH NCATS
Mar 2023 ACTIVE
A PHASE 3 RANDOMIZED CONTROLLED STUDY OF RENAL AUTOLOGOUS CELL THERAPY (REACT) IN SUBJECTS WITH TYPE 2 DIABETES AND CHRONIC KIDNEY DISEASE (REGEN-006)
Role: Principal Investigator
Funding: IQVIA LTD via PROKIDNEY
Aug 2022 ACTIVE
Outcomes and perspectives on treatment for critical limb ischemia in patients with end-stage renal disease
Role: Other
Funding: NATL INST OF HLTH NHLBI
Jul 2022 – Jun 2024
Together: Transforming and Translating Discovery to Improve Health
Role: Faculty
Funding: NATL INST OF HLTH NCATS
Mar 2022 ACTIVE
A Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Participants Who Have Thrombotic Microangiopathy Associated With a Trigger
Role: Principal Investigator
Funding: PPD INVESTIGATOR SERVICES LLC via ALEXION PHARMACEUTICALS
Aug 2021 – May 2024
Chronic aryl hydrocarbon receptor activation and skeletal myopathy in chronic kidney disease
Role: Other
Funding: NATL INST OF HLTH NIDDK
May 2020 ACTIVE
Development and Validation of Computational Algorithms to Assess Kidney Health in Electronic Health Records
Role: Other
Funding: NATL INST OF HLTH NIDDK
Dec 2019 ACTIVE
Molecular Mechanisms regulating peripheral arterial disease pathobiology in chronic kidney disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Oct 2019 ACTIVE
A multicentre international randomized parallel group double-blind placebo-controlled clinical trial of EMPAgliflozin once daily to assess cardio-renal outcomes in patients with chronic KIDNEY disease
Role: Principal Investigator
Funding: DUKE UNIVERSITY via BOEHRINGER INGELHEIM PHARM INC
Sep 2019 – May 2024
Sex Differences in Chronic and Acute Vascular Responses to Aerobic Exercise in Older Adults
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Dec 2018 ACTIVE
A multicentre international randomized parallel group double-blind placebo controlled clinical trial of EMPAgliflozin once daily to assess cardio-renal outcomes in patients with chronic KIDNEY disease
Role: Principal Investigator
Funding: DUKE UNIVERSITY via BOEHRINGER INGELHEIM INTL GmbH
Oct 2018 – Oct 2023
A PHASE 2 PROSPECTIVE, RANDOMIZED, DOUBLE-ARM, DEFERRED TREATMENT, OPEN-LABEL, REPEAT DOSE, SAFETY AND EFFICACY STUDY OF AUTOLOGOUS NEO KIDNEY AUGMENT (NKA) IN SUBJECTS WITH TYPE 2 DIABETES AND CHRONIC KIDNEY DISEASE
Role: Principal Investigator
Funding: CTI CLINICAL TRIAL SERVICES via REGENMED (CAYMAN) LTD
Sep 2018 ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Aug 2018 – Aug 2023
A PHASE II, OPEN-LABEL SAFETY AND TOLERABILITY STUDY OF AN AUTOLOGOUS NEO-KIDNEY AUGMENT (NKA) IN PATIENTS WITH TYPE 2 DIABETES AND CHRONIC KIDNEY DISEASE (REGEN-003)
Role: Principal Investigator
Funding: CTI CLINICAL TRIAL SERVICES via REGENMED (CAYMAN) LTD
Jun 2018 – May 2020
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Jun 2017 – Dec 2018
The SPRINT-Alzheimers, Seniors, and Kidney Study (SPRINT ASK)
Role: Principal Investigator
Funding: UNIV OF UTAH via NATL INST OF HLTH NIA
Jun 2017 – May 2018
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2017 ACTIVE
A Phase 2 Prospective, Randomized, Double-Arm, Deferred Treatment, Open-Label, Repeat Dose, Safety and Efficacy Study of Autologous Neo-Kidney (NKA) in SUbjects with Type 2 Diabetes and Chronic Kidney Disease.
Role: Principal Investigator
Funding: CTI CLINICAL TRIAL SERVICES via REGENMED (CAYMAN) LTD
Sep 2016 – Jan 2022
Vascular Smooth Muscle Lysyl Oxidase Mediated Increase in Vessel Stiffness and its Effect on Rho-Kinase Mechanosensors: A Novel Mechanism of Atherosclerosis in Chronic Kidney Disease?
Role: Other
Funding: NATL INST OF HLTH NHLBI
Jun 2016 – May 2017
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Mar 2016 – Sep 2023
USING THORACIC IMPEDANCE TO PREDICT HYPERKALEMIA, ADVERSE EVENTS, AND PROGRESSION TOWARDS DRY WEIGHT DURING DIALYSIS.
Role: Principal Investigator
Funding: TOSENSE
Jul 2015 – Jan 2019
Potential Therapeutic Use of Relaxin in Healing Cranial Bone Defects
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION via US DEPT OF DEFENSE
Jun 2015 – Oct 2021
REnal TrAIning & reteNtion (RETAIN) Program
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2015 – May 2016
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
May 2015 – May 2017
Establishing an Interdisciplinary Team and Competitive Platform for a Quantum Grant titled "Dialysis-Like Cancer Cell Removal"
Role: Project Manager
Funding: UF DIV OF SPONSORED RESEARCH
Feb 2014 ACTIVE
An Observational, Non-Interventional, Multi-Center, Multi-National Study of Patients with Atypical Hemolytic-Uremic Syndrome (aHUS Registry)
Role: Principal Investigator
Funding: ALEXION PHARMACEUTICALS
Sep 2013 – Aug 2016
NO Dysregulation of the Peripheral Clock in Diabetic Complications
Role: Principal Investigator
Funding: INDIANA UNIV via NATL INST OF HLTH NIDDK
Feb 2012 – Feb 2018
A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of A Selective Cytopheretic Device (SCD) In Patients with Acute Kidney Injury (AKI)
Role: Principal Investigator
Funding: CYTOPHERX
Sep 2011 – Sep 2016
Systolic Blood Pressure Intervention Trial (SPRINT) – Utah CCN
Role: Principal Investigator
Funding: UNIV OF UTAH via NATL INST OF HLTH
Aug 2011 – Feb 2020
Corpus Luteal Contribution to Maternal Pregnancy Physiology and Outcomes in ART
Role: Project Manager
Funding: NATL INST OF HLTH NICHD
Mar 2011 – May 2016
Otsuka Registry: An Observational prospective registry to identify demographic and clinical characteristics of patients hospitalized with euvolemic and hypervolemic hyponatremia and assess the comparative effectiveness of available treatments
Role: Principal Investigator
Funding: REGISTRAT
Jul 2007 – Dec 2020
Chair support from Johnson UFF 012724
Role: Principal Investigator
Funding: UF FOUNDATION
Apr 2007 – Dec 2020
Nephrology Research & Educ UFF Fund F001291
Role: Principal Investigator
Funding: UF FOUNDATION
Apr 2005 – Jun 2020
DCI Visiting Professor
Role: Principal Investigator
Funding: UF FOUNDATION
Oct 2002 – Oct 2019
Nephrology Hypertension Eminent Scholar
Role: Principal Investigator
Funding: UF FOUNDATION

Education

Fellowship – Nephrology
1998 · Beth Israel Deaconess Medical Center
Residency – Internal Medicine
1995 · Parkland Memorial Hospital
Internship – Internal Medicine
1993 · Parkland Memorial Hospital
Medical Degree
1992 · University of Southwestern
Bachelor of Science
1984 · Massachusetts Institute of Technology (MIT)

Contact Details

Phones:
Business:
(352) 273-8821
Emails:
Addresses:
Business Mailing:
1600 Archer Road
M100
GAINESVILLE FL 326100224
Business Street:
PO Box 100224
GAINESVILLE FL 32610