Mark S Segal, M.D., PH.D.
Senior Associate Dean For Faculty Affairs & Professional Development
About Mark S Segal
I am the senior associate dean for faculty affairs and professional development for the University of Florida College of Medicine and a professor of medicine in the UF Division of Nephrology, Hypertension & Renal Transplantation. I love the long-term patient-doctor relationship and the quantitative element of nephrology. I treat patients with lupus nephritis, ANCA vasculitis, aHUS and patients who are pregnant and have kidney disease. I strive to help patient’s live long, fulfilling lives without the need of dialysis or kidney transplantation.
I received my Bachelor of Science from the Massachusetts Institute of Technology (MIT), and my MD/PhD degrees from the University of Texas Southwestern Medical School. I completed an internal medicine internship and residency at Parkland Memorial Hospital and a nephrology fellowship at Beth Israel Deaconess Medical Center in Boston. I am board certified in internal medicine and nephrology by the American Board of Internal Medicine.
My research has been funded continuously by the National Institutes of Health (NIH), and I study the mechanism of cardiovascular disease in unique patient populations. As a physician and a scientist, my goal is to remain a lifelong learner, always reassessing the best and most effective way to provide individualized care to my patients.
When not helping patients, I enjoy home renovation, gardening and cooking.
Additional Positions:
Central Florida Kidney Center, Inc. Eminent Scholar Chair in Nephrology and Hypertension
2021 – Current
·
Professor of Medicine
2014 – Current
·
Teaching Profile
Courses Taught
2019-2020,2022-2024
PAS5010 Intro to Medicine 1
2014-2024
MDU4010 Cell Biology Seminar
2018
MDC7200 Medicine Clerkship
2016
BMS4905 Medical Sciences Senior Research
2014-2016
MDT7200 Elect Top/Medicine
2015
GMS7093 Introduction to Clinical and Translational Research
2015,2024-2025
BMS6638C Kidney & Urinary Tract
2015
GMS6683 Fundamentals of Vascular Physiology and Pathology
2006-2007,2009-2012,2012
MEL4003 Cell Biology Seminar
Board Certifications
-
Internal MedicineAmerican Board of Internal Medicine
-
NephrologyAmerican Board of Internal Medicine
Clinical Profile
Specialties
- Nephrology
Areas of Interest
- Glomerulonephritis
- Lupus Nephritis
- Necrotizing Vasculitis
- Systemic Lupus Erythematosus
- Thrombotic Thrombocytopenic Purpura
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-5502-2042
Publications
Academic Articles
2025
Association Between Use of WATCHMAN Device and 1-Year Mortality Using High-Dimensional Propensity Scores to Reduce Confounding.
Circulation. Cardiovascular quality and outcomes.
18(4)
[DOI] 10.1161/CIRCOUTCOMES.124.011188.
[PMID] 40026152.
2025
Epidemiology, trajectories and outcomes of acute kidney injury among hospitalized patients: a large retrospective multicenter cohort study.
Journal of nephrology.
[DOI] 10.1007/s40620-025-02234-4.
[PMID] 40113721.
2024
Altered lipid homeostasis and autophagy precipitate diffuse alveolar hemorrhage in murine lupus.
Autophagy reports.
3(1)
[DOI] 10.1080/27694127.2024.2379193.
[PMID] 39871963.
2024
Development and validation of a race-agnostic computable phenotype for kidney health in adult hospitalized patients.
PloS one.
19(4)
[DOI] 10.1371/journal.pone.0299332.
[PMID] 38652731.
2024
Ethics and Terminology for Opting In and Out.
JAMA internal medicine.
184(4):451-452
[DOI] 10.1001/jamainternmed.2023.7060.
[PMID] 38372980.
2024
Mobile Electrocardiograms in the Detection of Subclinical Atrial Fibrillation in High-Risk Outpatient Populations: Protocol for an Observational Study
JMIR Research Protocols.
13
[DOI] 10.2196/52647.
[PMID] 38801762.
2024
Outcomes among Patients with End-Stage Kidney Disease and Chronic Limb-Threatening Ischemia: A Population-based Cohort Study.
Annals of surgery.
[DOI] 10.1097/SLA.0000000000006566.
[PMID] 39471077.
2023
Initiative to improve the quality of patient care for chronic dialysis patients in the inpatient setting.
Hemodialysis international. International Symposium on Home Hemodialysis.
27(3):339-341
[DOI] 10.1111/hdi.13078.
[PMID] 36966510.
2023
Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis.
Clinical immunology (Orlando, Fla.).
248
[DOI] 10.1016/j.clim.2022.109213.
[PMID] 36566913.
2023
National Treatment Patterns and Outcomes for Hospitalized Patients with Chronic Limb-Threatening Ischemia and End-Stage Kidney Disease.
Vascular and endovascular surgery.
57(4):357-364
[DOI] 10.1177/15385744221146868.
[PMID] 36541126.
2023
Organizing Nephrologists at the State Level: The Florida Experience.
Clinical journal of the American Society of Nephrology : CJASN.
18(1):124-126
[DOI] 10.2215/CJN.09430822.
[PMID] 36344210.
2023
Pea hull fiber supplementation does not modulate uremic metabolites in adults receiving hemodialysis: a randomized, double-blind, controlled trial.
Frontiers in nutrition.
10
[DOI] 10.3389/fnut.2023.1179295.
[PMID] 37457968.
2022
Clinical Trajectories of Acute Kidney Injury in Surgical Sepsis: A Prospective Observational Study.
Annals of surgery.
275(6):1184-1193
[DOI] 10.1097/SLA.0000000000004360.
[PMID] 33196489.
2022
Early Biomarker Signatures in Surgical Sepsis.
The Journal of surgical research.
277:372-383
[DOI] 10.1016/j.jss.2022.04.052.
[PMID] 35569215.
2022
EARLY DIFFERENTIATION BETWEEN SEPSIS AND STERILE INFLAMMATION VIA URINARY GENE SIGNATURES OF METABOLIC DYSREGULATION.
Shock (Augusta, Ga.).
58(1):20-27
[DOI] 10.1097/SHK.0000000000001952.
[PMID] 35904146.
2022
Existing Transplant Nephrology Compensation Models and Opportunities for Equitable Pay.
Clinical journal of the American Society of Nephrology : CJASN.
17(9):1407-1409
[DOI] 10.2215/CJN.02010222.
[PMID] 35914793.
2022
Provision of Kidney Disease Education Service Is Associated with Improved Vascular Access Outcomes among US Incident Hemodialysis Patients.
Kidney360.
3(1):91-98
[DOI] 10.34067/KID.0004502021.
[PMID] 35368570.
2022
The Importance of Transplant Nephrology to a Successful Kidney Transplant Program.
Clinical journal of the American Society of Nephrology : CJASN.
17(9):1403-1406
[DOI] 10.2215/CJN.02000222.
[PMID] 35914794.
2021
Advancing Nephrology: Division Leaders Advise ASN.
Clinical journal of the American Society of Nephrology : CJASN.
16(2):319-327
[DOI] 10.2215/CJN.01550220.
[PMID] 32792352.
2021
Association of early initiation of dialysis with all-cause and cardiovascular mortality: A propensity score weighted analysis of the United States Renal Data System.
Hemodialysis international. International Symposium on Home Hemodialysis.
25(2):188-197
[DOI] 10.1111/hdi.12912.
[PMID] 33644974.
2021
Association of Intensive vs Standard Blood Pressure Control With Magnetic Resonance Imaging Biomarkers of Alzheimer Disease: Secondary Analysis of the SPRINT MIND Randomized Trial.
JAMA neurology.
[DOI] 10.1001/jamaneurol.2021.0178.
[PMID] 33683313.
2021
Association of persistent acute kidney injury and renal recovery with mortality in hospitalised patients.
BMJ health & care informatics.
28(1)
[DOI] 10.1136/bmjhci-2021-100458.
[PMID] 34876451.
2021
Circulating endothelial cells as predictor of long-term mortality and adverse cardiovascular outcomes in hemodialysis patients.
Seminars in dialysis.
34(2):163-169
[DOI] 10.1111/sdi.12943.
[PMID] 33280176.
2021
LC-MS lipidomics of renal biopsies for the diagnosis of Fabry disease.
Journal of mass spectrometry and advances in the clinical lab.
22:71-78
[DOI] 10.1016/j.jmsacl.2021.11.004.
[PMID] 34918004.
2021
Management of Cardiovascular Disease in Kidney Disease Study: Rationale and Design.
American journal of nephrology.
52(1):36-44
[DOI] 10.1159/000513567.
[PMID] 33640890.
2021
Nonatherosclerotic Vascular Abnormalities Associated with Chronic Kidney Disease.
Cardiology clinics.
39(3):415-425
[DOI] 10.1016/j.ccl.2021.04.012.
[PMID] 34247754.
2021
Pro Re Nata Antihypertensive Medications and Adverse Outcomes in Hospitalized Patients: A Propensity-Matched Cohort Study.
Hypertension (Dallas, Tex. : 1979).
78(2):516-524
[DOI] 10.1161/HYPERTENSIONAHA.121.17279.
[PMID] 34148363.
2021
Relationships between reproductive hormones and maternal pregnancy physiology in women conceiving with or without in vitro fertilization.
American journal of physiology. Regulatory, integrative and comparative physiology.
321(3):R454-R468
[DOI] 10.1152/ajpregu.00174.2020.
[PMID] 34346723.
2021
Utilization of CMS pre-ESRD Kidney Disease Education services and its associations with the home dialysis therapies.
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis.
41(5):453-462
[DOI] 10.1177/0896860820975586.
[PMID] 33258420.
2020
A Word of Caution in the Use of Hydroxychloroquine in the Elderly COVID-19 Population.
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.).
9(4):374-375
[DOI] 10.1097/APO.0000000000000314.
[PMID] 32740071.
2020
Discovery and Validation of Urinary Molecular Signature of Early Sepsis.
Critical care explorations.
2(10)
[DOI] 10.1097/CCE.0000000000000195.
[PMID] 33063018.
2020
Engineering magnetic nanoparticles and their integration with microfluidics for cell isolation.
Journal of colloid and interface science.
564:204-215
[DOI] 10.1016/j.jcis.2019.12.092.
[PMID] 31911225.
2020
Graft-versus-host disease of the kidney.
Hematology/oncology and stem cell therapy.
13(3):178-179
[DOI] 10.1016/j.hemonc.2019.01.003.
[PMID] 30807739.
2020
Maternal endothelial function, circulating endothelial cells, and endothelial progenitor cells in pregnancies conceived with or without in vitro fertilization.
American journal of physiology. Regulatory, integrative and comparative physiology.
318(6):R1091-R1102
[DOI] 10.1152/ajpregu.00015.2020.
[PMID] 32349514.
2020
Roxadustat for Anemia in Patients with Chronic Kidney Disease.
The New England journal of medicine.
383(1)
[DOI] 10.1056/NEJMc1913712.
[PMID] 32610000.
2020
Tubular Biomarkers and Chronic Kidney Disease Progression in SPRINT Participants.
American journal of nephrology.
51(10):797-805
[DOI] 10.1159/000509978.
[PMID] 32906135.
2019
Antihypertensive therapy prescribing patterns and correlates of blood pressure control among hypertensive patients with chronic kidney disease.
Journal of clinical hypertension (Greenwich, Conn.).
21(1):91-101
[DOI] 10.1111/jch.13429.
[PMID] 30427124.
2019
Increased Preeclampsia Risk and Reduced Aortic Compliance With In Vitro Fertilization Cycles in the Absence of a Corpus Luteum.
Hypertension (Dallas, Tex. : 1979).
73(3):640-649
[DOI] 10.1161/HYPERTENSIONAHA.118.12043.
[PMID] 30636552.
2019
Integrating Point-of-Care Ultrasonography Into Nephrology Fellowship Training: A Model Curriculum.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
74(1):1-5
[DOI] 10.1053/j.ajkd.2019.02.002.
[PMID] 30910369.
2019
Maternal Cardiovascular Dysregulation During Early Pregnancy After In Vitro Fertilization Cycles in the Absence of a Corpus Luteum.
Hypertension (Dallas, Tex. : 1979).
74(3):705-715
[DOI] 10.1161/HYPERTENSIONAHA.119.13015.
[PMID] 31352818.
2019
Myeloid-derived suppressor cell function and epigenetic expression evolves over time after surgical sepsis.
Critical care (London, England).
23(1)
[DOI] 10.1186/s13054-019-2628-x.
[PMID] 31722736.
2019
Opioid Safety and Concomitant Benzodiazepine Use in End-Stage Renal Disease Patients.
Pain research & management.
2019
[DOI] 10.1155/2019/3865924.
[PMID] 31772694.
2019
Potential influence of the corpus luteum on circulating reproductive and volume regulatory hormones, angiogenic and immunoregulatory factors in pregnant women.
American journal of physiology. Endocrinology and metabolism.
317(4):E677-E685
[DOI] 10.1152/ajpendo.00225.2019.
[PMID] 31408378.
2019
Serum Sodium and Pulse Pressure in SPRINT.
American journal of hypertension.
32(7):649-656
[DOI] 10.1093/ajh/hpz055.
[PMID] 30977767.
2019
The utility of trough mycophenolic acid levels for the management of lupus nephritis.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
34(1):83-89
[DOI] 10.1093/ndt/gfy026.
[PMID] 29548021.
2018
Activation of the β-common receptor by erythropoietin impairs acetylcholine-mediated vasodilation in mouse mesenteric arterioles.
Physiological reports.
6(12)
[DOI] 10.14814/phy2.13751.
[PMID] 29939494.
2018
Benchmarking clinical outcomes and the immunocatabolic phenotype of chronic critical illness after sepsis in surgical intensive care unit patients.
The journal of trauma and acute care surgery.
84(2):342-349
[DOI] 10.1097/TA.0000000000001758.
[PMID] 29251709.
2018
Chronic Critical Illness and the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome.
Frontiers in immunology.
9
[DOI] 10.3389/fimmu.2018.01511.
[PMID] 30013565.
2018
Computational design and experimental characterization of a novel β-common receptor inhibitory peptide.
Peptides.
104:1-6
[DOI] 10.1016/j.peptides.2018.04.001.
[PMID] 29635062.
2018
Development of a personalized diagnostic model for kidney stone disease tailored to acute care by integrating large clinical, demographics and laboratory data: the diagnostic acute care algorithm – kidney stones (DACA-KS).
BMC medical informatics and decision making.
18(1)
[DOI] 10.1186/s12911-018-0652-4.
[PMID] 30119627.
2018
Gender, blood pressure, and cardiovascular and renal outcomes in adults with hypertension from the Systolic Blood Pressure Intervention Trial.
Journal of hypertension.
36(4):904-915
[DOI] 10.1097/HJH.0000000000001619.
[PMID] 29493562.
2018
Not all that is red is blood: a curious case of chromaturia.
Clinical case reports.
6(6):1179-1180
[DOI] 10.1002/ccr3.1514.
[PMID] 29881591.
2018
Persistent inflammation, immunosuppression, and catabolism and the development of chronic critical illness after surgery.
Surgery.
164(2):178-184
[DOI] 10.1016/j.surg.2018.04.011.
[PMID] 29807651.
2018
Pulse pressure, arterial stiffening, and the efficacy of renin-angiotensin system inhibitor combinations.
Journal of human hypertension.
32(2):165-166
[DOI] 10.1038/s41371-017-0014-1.
[PMID] 29230003.
2018
Wave reflections and global arterial compliance during normal human pregnancy.
Physiological reports.
6(24)
[DOI] 10.14814/phy2.13947.
[PMID] 30578623.
2017
Case Report of Spontaneous Remission of Biopsy-Proven Idiopathic Immune Complex-Mediated Membranoproliferative Glomerulonephritis.
Case reports in nephrology and dialysis.
7(2):81-90
[DOI] 10.1159/000477660.
[PMID] 28868298.
2017
Comparison of multiple non-invasive methods of measuring cardiac output during pregnancy reveals marked heterogeneity in the magnitude of cardiac output change between women.
Physiological reports.
5(8)
[DOI] 10.14814/phy2.13223.
[PMID] 28438984.
2017
Sepsis and Critical Illness Research Center investigators: protocols and standard operating procedures for a prospective cohort study of sepsis in critically ill surgical patients.
BMJ open.
7(7)
[DOI] 10.1136/bmjopen-2016-015136.
[PMID] 28765125.
2017
Tubulointerstitial Nephritis in Sjögren Syndrome Treated With Mycophenolate Mofetil.
Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases.
23(7):402-403
[DOI] 10.1097/RHU.0000000000000595.
[PMID] 28937480.
2017
Using Organizational Philosophy to Create a Self-Sustaining Compensation Plan Without Harming Academic Missions.
Academic medicine : journal of the Association of American Medical Colleges.
92(8):1133-1137
[DOI] 10.1097/ACM.0000000000001484.
[PMID] 28746136.
2016
A case of isolated renal involvement of polyarteritis nodosa successfully treated with steroid monotherapy.
BMJ case reports.
2016
[DOI] 10.1136/bcr-2016-215702.
[PMID] 27440849.
2016
A Novel Mechanism for Generating the Interferon Signature in Lupus: Opsonization of Dead Cells by Complement and IgM.
Arthritis & rheumatology (Hoboken, N.J.).
68(12):2917-2928
[DOI] 10.1002/art.39781.
[PMID] 27274010.
2016
Acute and Chronic Kidney Disease and Cardiovascular Mortality After Major Surgery.
Annals of surgery.
264(6):987-996
[PMID] 26756753.
2016
Effects of Long-Term Type I Interferon on the Arterial Wall and Smooth Muscle Progenitor Cells Differentiation.
Arteriosclerosis, thrombosis, and vascular biology.
36(2):266-73
[DOI] 10.1161/ATVBAHA.115.306767.
[PMID] 26634654.
2016
Nebivolol Effects on Nitric Oxide Levels, Blood Pressure, and Renal Function in Kidney Transplant Patients.
Journal of clinical hypertension (Greenwich, Conn.).
18(8):741-9
[DOI] 10.1111/jch.12745.
[PMID] 26692375.
2015
Cost and Mortality Associated With Postoperative Acute Kidney Injury.
Annals of surgery.
261(6):1207-14
[DOI] 10.1097/SLA.0000000000000732.
[PMID] 24887982.
2015
DNA Aptamer Assembly as a Vascular Endothelial Growth Factor Receptor Agonist.
Nucleic acid therapeutics.
25(5):227-34
[DOI] 10.1089/nat.2014.0519.
[PMID] 26125598.
2015
Fiber supplementation lowers plasma p-cresol in chronic kidney disease patients.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
25(3):316-20
[DOI] 10.1053/j.jrn.2014.09.002.
[PMID] 25446837.
2015
Heart failure and chronic kidney disease: should we use spironolactone?
The American journal of the medical sciences.
350(2):147-51
[DOI] 10.1097/MAJ.0000000000000514.
[PMID] 26086152.
2015
Higher levels of adiponectin in vascular endothelial cells are associated with greater brachial artery flow-mediated dilation in older adults.
Experimental gerontology.
63:1-7
[DOI] 10.1016/j.exger.2014.12.018.
[PMID] 25572013.
2015
Impact of Hydroxychloroquine on Atherosclerosis and Vascular Stiffness in the Presence of Chronic Kidney Disease.
PloS one.
10(9)
[DOI] 10.1371/journal.pone.0139226.
[PMID] 26414017.
2015
Mild renal dysfunction and long-term adverse outcomes in women with chest pain: results from the National Heart, Lung, and Blood Institute-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
American heart journal.
169(3):412-8
[DOI] 10.1016/j.ahj.2014.12.010.
[PMID] 25728732.
2015
Renal function and coronary microvascular dysfunction in women with symptoms/signs of ischemia.
PloS one.
10(5)
[DOI] 10.1371/journal.pone.0125374.
[PMID] 25951606.
2015
The effect of the addition of allopurinol on blood pressure control in African Americans treated with a thiazide-like diuretic.
Journal of the American Society of Hypertension : JASH.
9(8):610-619.e1
[DOI] 10.1016/j.jash.2015.05.009.
[PMID] 26140739.
2014
End-stage renal disease in African Americans with lupus nephritis is associated with APOL1.
Arthritis & rheumatology (Hoboken, N.J.).
66(2):390-6
[DOI] 10.1002/art.38220.
[PMID] 24504811.
2014
Uric acid inhibition of dipeptidyl peptidase IV in vitro is dependent on the intracellular formation of triuret.
Experimental cell research.
326(1):136-42
[DOI] 10.1016/j.yexcr.2014.05.025.
[PMID] 24925478.
2014
Vasoreparative dysfunction of CD34+ cells in diabetic individuals involves hypoxic desensitization and impaired autocrine/paracrine mechanisms.
PloS one.
9(4)
[DOI] 10.1371/journal.pone.0093965.
[PMID] 24713821.
2013
Evaluation of stability and sensitivity of cell fluorescent labels when used for cell migration.
Journal of fluorescence.
23(5):975-87
[DOI] 10.1007/s10895-013-1224-8.
[PMID] 23722994.
2013
Foods with added fiber lower serum creatinine levels in patients with chronic kidney disease.
Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation.
23(2):e29-32
[DOI] 10.1053/j.jrn.2012.04.002.
[PMID] 22739658.
2013
Long-term type 1 diabetes influences haematopoietic stem cells by reducing vascular repair potential and increasing inflammatory monocyte generation in a murine model.
Diabetologia.
56(3):644-53
[DOI] 10.1007/s00125-012-2781-0.
[PMID] 23192694.
2013
Lupus nephritis and end-stage kidney disease.
The American journal of the medical sciences.
346(4):319-23
[DOI] 10.1097/MAJ.0b013e31827f4ee3.
[PMID] 23370533.
2013
Mineralocorticoid receptors modulate vascular endothelial function in human obesity.
Clinical science (London, England : 1979).
125(11):513-20
[DOI] 10.1042/CS20130200.
[PMID] 23786536.
2013
National surgical quality improvement program underestimates the risk associated with mild and moderate postoperative acute kidney injury.
Critical care medicine.
41(11):2570-83
[DOI] 10.1097/CCM.0b013e31829860fc.
[PMID] 23928835.
2013
Number and function of bone-marrow derived angiogenic cells and coronary flow reserve in women without obstructive coronary artery disease: a substudy of the NHLBI-sponsored Women’s Ischemia Syndrome Evaluation (WISE).
PloS one.
8(12)
[DOI] 10.1371/journal.pone.0081595.
[PMID] 24312563.
2013
Racial and socioeconomic disparities in the allocation of expanded criteria donor kidneys.
Clinical journal of the American Society of Nephrology : CJASN.
8(12):2158-64
[DOI] 10.2215/CJN.01430213.
[PMID] 24115196.
2013
The role of uric acid in the pathogenesis of human cardiovascular disease.
Heart (British Cardiac Society).
99(11):759-66
[DOI] 10.1136/heartjnl-2012-302535.
[PMID] 23343689.
2012
Effects of high-fructose corn syrup and sucrose on the pharmacokinetics of fructose and acute metabolic and hemodynamic responses in healthy subjects.
Metabolism: clinical and experimental.
61(5):641-51
[DOI] 10.1016/j.metabol.2011.09.013.
[PMID] 22152650.
2012
Evaluation of Norepinephrine Transporter Expression and Metaiodobenzylguanidine Avidity in Neuroblastoma: A Report from the Children’s Oncology Group.
International journal of molecular imaging.
2012
[DOI] 10.1155/2012/250834.
[PMID] 23050139.
2012
Relaxin increases human endothelial progenitor cell NO and migration and vasculogenesis in mice.
Blood.
119(2):629-36
[DOI] 10.1182/blood-2011-04-346007.
[PMID] 22028476.
2011
Downregulation of EMX2 is associated with clinical outcomes in lung adenocarcinoma patients.
Clinical lung cancer.
12(4):237-44
[DOI] 10.1016/j.cllc.2011.03.025.
[PMID] 21726823.
2011
Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.
Arthritis research & therapy.
13(3)
[DOI] 10.1186/ar3334.
[PMID] 21569292.
2011
Relaxin induces rapid dilation of rodent small renal and human subcutaneous arteries via PI3 kinase and nitric oxide.
Endocrinology.
152(7):2786-96
[DOI] 10.1210/en.2010-1126.
[PMID] 21558316.
2011
Screening prevalence and incidence of colorectal cancer among American Indian/Alaskan natives in the Indian Health Service.
Digestive diseases and sciences.
56(7):2104-13
[DOI] 10.1007/s10620-010-1528-3.
[PMID] 21234688.
2011
The relative importance of predictors of body mass index change, overweight and obesity in adolescent girls.
International journal of pediatric obesity : IJPO : an official journal of the International Association for the Study of Obesity.
6(2-2):e233-42
[DOI] 10.3109/17477166.2010.545410.
[PMID] 21244233.
2010
Endogenous type-I interferon activity is not associated with depression or fatigue in systemic lupus erythematosus.
Journal of neuroimmunology.
223(1-2):13-9
[DOI] 10.1016/j.jneuroim.2010.03.018.
[PMID] 20416954.
2010
Endothelial progenitor cells and endothelial vesicles – what is the significance for patients with chronic kidney disease?
Blood purification.
29(2):158-62
[DOI] 10.1159/000245643.
[PMID] 20093822.
2010
Induction of nitric oxide by erythropoietin is mediated by the {beta} common receptor and requires interaction with VEGF receptor 2.
Blood.
115(4):896-905
[DOI] 10.1182/blood-2009-04-216432.
[PMID] 19965681.
2010
Monocyte surface expression of Fcgamma receptor RI (CD64), a biomarker reflecting type-I interferon levels in systemic lupus erythematosus.
Arthritis research & therapy.
12(3)
[DOI] 10.1186/ar3017.
[PMID] 20478071.
2010
Uric acid and hypertension: cause or effect?
Current rheumatology reports.
12(2):108-17
[DOI] 10.1007/s11926-010-0094-1.
[PMID] 20425019.
2009
Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery.
Circulation.
119(18):2444-53
[DOI] 10.1161/CIRCULATIONAHA.108.800011.
[PMID] 19398670.
2009
Citrulline dependence of anti-cyclic citrullinated peptide antibodies in systemic lupus erythematosus as a marker of deforming/erosive arthritis.
The Journal of rheumatology.
36(12):2682-90
[DOI] 10.3899/jrheum.090338.
[PMID] 19884269.
2009
Diabetic retinopathy is associated with bone marrow neuropathy and a depressed peripheral clock.
The Journal of experimental medicine.
206(13):2897-906
[DOI] 10.1084/jem.20090889.
[PMID] 19934019.
2009
Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes?
Endocrine reviews.
30(1):96-116
[DOI] 10.1210/er.2008-0033.
[PMID] 19151107.
2009
Increased expression of FcgammaRI/CD64 on circulating monocytes parallels ongoing inflammation and nephritis in lupus.
Arthritis research & therapy.
11(1)
[DOI] 10.1186/ar2590.
[PMID] 19144150.
2009
Lambda chops: creation of site-directed mutants in insertable fragments utilizing Gateway technology.
Molecular biotechnology.
42(3):275-81
[DOI] 10.1007/s12033-009-9158-8.
[PMID] 19301156.
2009
Long-term risk of mortality and acute kidney injury during hospitalization after major surgery.
Annals of surgery.
249(5):851-8
[DOI] 10.1097/SLA.0b013e3181a40a0b.
[PMID] 19387314.
2009
Lowering blood pressure blocks mesangiolysis and mesangial nodules, but not tubulointerstitial injury, in diabetic eNOS knockout mice.
The American journal of pathology.
174(4):1221-9
[DOI] 10.2353/ajpath.2009.080605.
[PMID] 19246639.
2009
Role of relaxin in maternal systemic and renal vascular adaptations during gestation.
Annals of the New York Academy of Sciences.
1160:304-12
[DOI] 10.1111/j.1749-6632.2009.03829.x.
[PMID] 19416209.
2009
Simultaneous determination of uric acid metabolites allantoin, 6-aminouracil, and triuret in human urine using liquid chromatography-mass spectrometry.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
877(1-2):65-70
[DOI] 10.1016/j.jchromb.2008.11.029.
[PMID] 19081307.
2009
Urinary CD80 excretion increases in idiopathic minimal-change disease.
Journal of the American Society of Nephrology : JASN.
20(2):260-6
[DOI] 10.1681/ASN.2007080836.
[PMID] 19056875.
2008
Carbon monoxide and nitric oxide mediate cytoskeletal reorganization in microvascular cells via vasodilator-stimulated phosphoprotein phosphorylation: evidence for blunted responsiveness in diabetes.
Diabetes.
57(9):2488-94
[DOI] 10.2337/db08-0381.
[PMID] 18559661.
2008
How safe is fructose for persons with or without diabetes?
The American journal of clinical nutrition.
88(5):1189-90
[PMID] 18996851.
2008
Long-term engraftment of bone marrow-derived cells in the intimal hyperplasia lesion of autologous vein grafts.
The American journal of pathology.
172(3):839-48
[DOI] 10.2353/ajpath.2008.070840.
[PMID] 18276778.
2008
Tacrolimus rescue therapy in resistant or relapsing cases of primary glomerulonephritis.
Journal of nephrology.
21(5):713-21
[PMID] 18949726.
2007
A breakthrough in diabetic nephropathy: the role of endothelial dysfunction.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
22(10):2775-7
[PMID] 17595179.
2007
Autoantibodies to RNA helicase A: a new serologic marker of early lupus.
Arthritis and rheumatism.
56(2):596-604
[PMID] 17265494.
2007
Is the fructose index more relevant with regards to cardiovascular disease than the glycemic index?
European journal of nutrition.
46(7):406-17
[PMID] 17763967.
2007
Mitomycin- and calcineurin-associated HUS, endothelial dysfunction and endothelial repair: a new paradigm for the puzzle?
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
22(2):617-20
[PMID] 17041000.
2007
Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease.
The American journal of clinical nutrition.
86(4):899-906
[PMID] 17921363.
2007
Retinal and choroidal microangiopathies: therapeutic opportunities.
Microvascular research.
74(2-3):131-44
[PMID] 17585951.
2007
Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus.
Arthritis and rheumatism.
56(11):3759-69
[PMID] 17968925.
2007
Urinary analysis of 8-oxoguanine, 8-oxoguanosine, fapy-guanine and 8-oxo-2′-deoxyguanosine by high-performance liquid chromatography-electrospray tandem mass spectrometry as a measure of oxidative stress.
Journal of chromatography. A.
1167(1):54-62
[PMID] 17765254.
2006
A case of unfulfilled expectations. Cytokines in idiopathic minimal lesion nephrotic syndrome.
Pediatric nephrology (Berlin, Germany).
21(5):603-10
[PMID] 16525836.
2006
Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases.
Arthritis research & therapy.
8(4)
[PMID] 16846524.
2006
Endothelial health and diversity in the kidney.
Journal of the American Society of Nephrology : JASN.
17(2):323-4
[PMID] 16434502.
2006
Nitric oxide cytoskeletal-induced alterations reverse the endothelial progenitor cell migratory defect associated with diabetes.
Diabetes.
55(1):102-9
[PMID] 16380482.
2006
Short-term atorvastatin treatment enhances specific antibody production following tetanus toxoid vaccination in healthy volunteers.
Vaccine.
24(19):4035-40
[PMID] 16464519.
2006
Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular disease.
Kidney international.
69(10):1722-5
[PMID] 16598194.
2006
Urinary biomarkers in lupus nephritis.
Autoimmunity reviews.
5(6):383-8
[PMID] 16890891.
2005
A novel mouse model of autologous venous graft intimal hyperplasia.
The Journal of surgical research.
126(1):106-13
[PMID] 15916983.
2005
Association of anti-nucleoprotein autoantibodies with upregulation of Type I interferon-inducible gene transcripts and dendritic cell maturation in systemic lupus erythematosus.
Clinical immunology (Orlando, Fla.).
117(3):238-50
[PMID] 16126005.
2005
Circulating endothelial cells are associated with future vascular events in hemodialysis patients.
Kidney international.
67(3):1078-83
[PMID] 15698448.
2005
Essential hypertension, progressive renal disease, and uric acid: a pathogenetic link?
Journal of the American Society of Nephrology : JASN.
16(7):1909-19
[PMID] 15843466.
2005
High sensitivity C-reactive protein in systemic lupus erythematosus: relation to disease activity, clinical presentation and implications for cardiovascular risk.
Lupus.
14(8):576-82
[PMID] 16175928.
2005
SDF-1 is both necessary and sufficient to promote proliferative retinopathy.
The Journal of clinical investigation.
115(1):86-93
[PMID] 15630447.
2004
Diuretic-induced hyperuricemia does not decrease cardiovascular risk.
Journal of hypertension.
22(7):1415-7; author reply 1417
[PMID] 15201561.
2004
Management and outcomes of care of fever in early infancy.
JAMA.
291(10):1203-12
[PMID] 15010441.
2004
Real-time analysis of apoptosis in vivo.
Methods in cell biology.
75:343-54
[PMID] 15603432.
2004
Strong association of a functional polymorphism in the monocyte chemoattractant protein 1 promoter gene with lupus nephritis.
Arthritis and rheumatism.
50(6):1842-9
[PMID] 15188361.
2004
The 1.4-MDa apoptosome is a critical intermediate in apoptosome maturation.
American journal of physiology. Cell physiology.
287(3):C664-72
[PMID] 15128503.
2004
Thrombotic microangiopathy associated with unusual viral sequences in HIV-1-positive patients.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association.
19(5):1129-35
[PMID] 14993479.
2004
Vitreous levels of vascular endothelial growth factor and stromal-derived factor 1 in patients with diabetic retinopathy and cystoid macular edema before and after intraocular injection of triamcinolone.
Archives of ophthalmology (Chicago, Ill. : 1960).
122(12):1801-7
[PMID] 15596583.
2003
Circulating endothelial cells as potential markers of the state of the endothelium in hemodialysis patients.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
42(4):704-12
[PMID] 14520620.
2003
Factors associated with future amputation among patients undergoing hemodialysis: results from the Dialysis Morbidity and Mortality Study Waves 3 and 4.
American journal of kidney diseases : the official journal of the National Kidney Foundation.
41(1):162-70
[PMID] 12500233.
2003
Intimal exuberance: veins in jeopardy.
The American journal of pathology.
162(6):1759-61
[PMID] 12759233.
2002
Air pollution and hospital admissions for ischemic heart disease in persons with congestive heart failure or arrhythmia.
Environmental health perspectives.
110(12):1247-52
[PMID] 12460805.
2002
Circulating endothelial cells: tea leaves for renal disease.
American journal of physiology. Renal physiology.
283(1):F11-9
[PMID] 12060582.
2002
Marker for real-time analysis of caspase activity in intact cells.
BioTechniques.
33(6):1284-7, 1289
[PMID] 12503313.
2002
Regulation of plasminogen activator inhibitor (PAI)-1 expression in a human trophoblast cell line by glucocorticoid (GC) and transforming growth factor (TGF)-beta.
Placenta.
23(10):727-34
[PMID] 12398812.
2001
Effect of pH, ionic charge, and osmolality on cytochrome c-mediated caspase-3 activity.
American journal of physiology. Cell physiology.
281(4):C1196-204
[PMID] 11546656.
1999
Antiangiogenic activity of restin, NC10 domain of human collagen XV: comparison to endostatin.
Biochemical and biophysical research communications.
255(3):735-9
[PMID] 10049780.
1999
Endostatin induces endothelial cell apoptosis.
The Journal of biological chemistry.
274(17):11721-6
[PMID] 10206987.
1999
Kringle 5 causes cell cycle arrest and apoptosis of endothelial cells.
Biochemical and biophysical research communications.
258(3):668-73
[PMID] 10329443.
1996
Development of neuronal precursor cells and functional postmitotic neurons from embryonic stem cells in vitro.
Mechanisms of development.
59(1):89-102
[PMID] 8892235.
1993
Age-related cognitive deficits in rats are associated with a combined loss of cholinergic and serotonergic functions.
Annals of the New York Academy of Sciences.
695:254-7
[PMID] 8239292.
1992
Disulfide bond formation during the folding of influenza virus hemagglutinin.
The Journal of cell biology.
118(2):227-44
[PMID] 1321156.
1992
Serum beta 2-microglobulin and prediction of progression to AIDS in HIV infection.
Lancet (London, England).
339(8807):1436-40
[PMID] 1351128.
1991
A comparison of black and white family caregivers experience with dementia.
Journal of National Black Nurses' Association : JNBNA.
5(1):29-41
[PMID] 1885954.
1990
The influence of oral potassium chloride on blood pressure in hypertensive men on a low-sodium diet.
The New England journal of medicine.
322(9):569-74
[PMID] 2406601.
1964
CHRONIC BRONCHITIS.
The New England journal of medicine.
270:894-7 CONTD
[PMID] 14112454.
Presentations
2023-05-19
Volume Crises
State
/
Other.
Seminar.
UF
Grants
May 2025
ACTIVE
A prospective, multicenter, single arm, open-label, early feasibility study to evaluate initial safety and device design concept of HyperQureTM RDN System, laparoscopic renal denervation therapy, in patients with resistant antihypertensive on three (3) or more antihypertensive medications
Role: Principal Investigator
Funding: SYNEOS HEALTH
Sep 2024
ACTIVE
Studies of Heart & Kidney Protection with BI 690517 in combination
with empagliflozin: A multicenter, international, randomized,
double-blind, placebo-controlled clinical trial of the aldosterone
synthase inhibitor BI 690517 in combination with empagliflozin in
patients with chronic kidney disease
Role: Principal Investigator
Funding: DUKE UNIVERSITY CLINICAL RES INST
via BOEHRINGER INGELHEIM PHARM INC
Dec 2023
– Sep 2024
A LONG-TERM FOLLOW-UP STUDY OF PARTICIPANTS EXPOSED TO RENAL AUTOLOGOUS CELL THERAPY (REACT) FROM STUDIES RMCL-002, REGEN-003, REGEN-004
Role: Principal Investigator
Funding: PROKIDNEY
Jul 2023
ACTIVE
Together: Transforming and Translating Discovery to Improve Health
Role: Faculty
Funding: NATL INST OF HLTH NCATS
Mar 2023
ACTIVE
A PHASE 3 RANDOMIZED CONTROLLED STUDY OF RENAL AUTOLOGOUS CELL THERAPY (REACT) IN SUBJECTS WITH TYPE 2 DIABETES AND CHRONIC KIDNEY DISEASE (REGEN-006)
Role: Principal Investigator
Funding: PROKIDNEY
Aug 2022
ACTIVE
Outcomes and perspectives on treatment for critical limb ischemia in patients with end-stage renal disease
Role: Other
Funding: NATL INST OF HLTH NHLBI
Jul 2022
– Jun 2024
Together: Transforming and Translating Discovery to Improve Health
Role: Faculty
Funding: NATL INST OF HLTH NCATS
Mar 2022
– Jan 2024
A Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Ravulizumab in Adult Participants Who Have Thrombotic Microangiopathy Associated With a Trigger
Role: Principal Investigator
Funding: ALEXION PHARMACEUTICALS
Aug 2021
– May 2024
Chronic aryl hydrocarbon receptor activation and skeletal myopathy in chronic kidney disease
Role: Other
Funding: NATL INST OF HLTH NIDDK
May 2020
– Oct 2024
Development and Validation of Computational Algorithms to Assess Kidney Health in Electronic Health Records
Role: Other
Funding: NATL INST OF HLTH NIDDK
Dec 2019
ACTIVE
Molecular Mechanisms regulating peripheral arterial disease pathobiology in chronic kidney disease
Role: Co-Investigator
Funding: NATL INST OF HLTH NHLBI
Oct 2019
– Oct 2024
A multicentre international randomized parallel group double-blind placebo-controlled clinical trial of EMPAgliflozin once daily to assess cardio-renal outcomes in patients with chronic KIDNEY disease
Role: Principal Investigator
Funding: DUKE UNIVERSITY
via BOEHRINGER INGELHEIM PHARM INC
Sep 2019
– May 2024
Sex Differences in Chronic and Acute Vascular Responses to Aerobic Exercise in Older Adults
Role: Co-Investigator
Funding: NATL INST OF HLTH NIA
Dec 2018
– Mar 2022
A multicentre international randomized parallel group double-blind
placebo controlled clinical trial of EMPAgliflozin once daily to assess cardio-renal outcomes in patients with chronic KIDNEY disease
Role: Principal Investigator
Funding: DUKE UNIVERSITY
via BOEHRINGER INGELHEIM INTL GmbH
Oct 2018
– Oct 2023
A PHASE 2 PROSPECTIVE, RANDOMIZED, DOUBLE-ARM, DEFERRED TREATMENT, OPEN-LABEL, REPEAT DOSE, SAFETY AND EFFICACY STUDY OF AUTOLOGOUS NEO KIDNEY AUGMENT (NKA) IN SUBJECTS WITH TYPE 2 DIABETES AND CHRONIC KIDNEY DISEASE
Role: Principal Investigator
Funding: CTI CLINICAL TRIAL SERVICES
via REGENMED (CAYMAN) LTD
Sep 2018
ACTIVE
Sparking Advancements in Genomic Medicine?
Role: Project Manager
Funding: NATL INST OF HLTH NHGRI
Aug 2018
– Nov 2020
A PHASE II, OPEN-LABEL SAFETY AND TOLERABILITY STUDY OF AN
AUTOLOGOUS NEO-KIDNEY AUGMENT (NKA) IN PATIENTS WITH
TYPE 2 DIABETES AND CHRONIC KIDNEY DISEASE (REGEN-003)
Role: Principal Investigator
Funding: CTI CLINICAL TRIAL SERVICES
via REGENMED (CAYMAN) LTD
Jun 2018
– May 2020
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Jun 2017
– Dec 2018
The SPRINT-Alzheimers, Seniors, and Kidney Study (SPRINT ASK)
Role: Principal Investigator
Funding: UNIV OF UTAH
via NATL INST OF HLTH NIA
Jun 2017
– May 2018
PICS: A New Horizon for Surgical Critical Care
Role: Co-Investigator
Funding: NATL INST OF HLTH NIGMS
Apr 2017
– Aug 2024
A Phase 2 Prospective, Randomized, Double-Arm, Deferred Treatment, Open-Label, Repeat Dose, Safety and Efficacy Study of Autologous Neo-Kidney (NKA) in SUbjects with Type 2 Diabetes and Chronic Kidney Disease.
Role: Principal Investigator
Funding: REGENMED (CAYMAN) LTD
Sep 2016
– Jan 2022
Vascular Smooth Muscle Lysyl Oxidase Mediated Increase in Vessel Stiffness and its Effect on Rho-Kinase Mechanosensors: A Novel Mechanism of Atherosclerosis in Chronic Kidney Disease?
Role: Other
Funding: NATL INST OF HLTH NHLBI
Jun 2016
– May 2017
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
Mar 2016
– Sep 2023
USING THORACIC IMPEDANCE TO PREDICT HYPERKALEMIA, ADVERSE EVENTS, AND PROGRESSION TOWARDS DRY WEIGHT DURING DIALYSIS.
Role: Principal Investigator
Funding: TOSENSE
Jul 2015
– Jan 2019
Potential Therapeutic Use of Relaxin in Healing Cranial Bone Defects
Role: Project Manager
Funding: US ARMY MED RES ACQUISITION
via US DEPT OF DEFENSE
Jun 2015
– Oct 2021
REnal TrAIning & reteNtion (RETAIN) Program
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2015
– May 2016
PICS: A New Horizon for Surgical Critical Care
Role: Project Manager
Funding: NATL INST OF HLTH NIGMS
May 2015
– May 2017
Establishing an Interdisciplinary Team and Competitive Platform for a Quantum Grant titled "Dialysis-Like Cancer Cell Removal"
Role: Project Manager
Funding: UF DIV OF SPONSORED RESEARCH
Feb 2014
ACTIVE
An Observational, Non-Interventional, Multi-Center, Multi-National Study of Patients with Atypical Hemolytic-Uremic Syndrome (aHUS Registry)
Role: Principal Investigator
Funding: ALEXION PHARMACEUTICALS
Sep 2013
– Aug 2016
NO Dysregulation of the Peripheral Clock in Diabetic Complications
Role: Principal Investigator
Funding: INDIANA UNIV
via NATL INST OF HLTH NIDDK
Feb 2012
– Feb 2018
A Multi-Center, Randomized, Controlled, Pivotal Study to Assess the Safety and Efficacy of A Selective Cytopheretic Device (SCD) In Patients with Acute Kidney Injury (AKI)
Role: Principal Investigator
Funding: CYTOPHERX
Sep 2011
– Sep 2016
Systolic Blood Pressure Intervention Trial (SPRINT) – Utah CCN
Role: Principal Investigator
Funding: UNIV OF UTAH
via NATL INST OF HLTH
Aug 2011
– Feb 2020
Corpus Luteal Contribution to Maternal Pregnancy Physiology and Outcomes in ART
Role: Project Manager
Funding: NATL INST OF HLTH NICHD
Mar 2011
– May 2016
Otsuka Registry: An Observational prospective registry to identify demographic and clinical characteristics of patients hospitalized with euvolemic and hypervolemic hyponatremia and assess the comparative effectiveness of available treatments
Role: Principal Investigator
Funding: REGISTRAT
Jul 2007
– Dec 2020
Chair support from Johnson UFF 012724
Role: Principal Investigator
Funding: UF FOUNDATION
Apr 2007
– Dec 2020
Nephrology Research & Educ UFF Fund F001291
Role: Principal Investigator
Funding: UF FOUNDATION
Apr 2005
– Jun 2020
DCI Visiting Professor
Role: Principal Investigator
Funding: UF FOUNDATION
Oct 2002
– Oct 2019
Nephrology Hypertension Eminent Scholar
Role: Principal Investigator
Funding: UF FOUNDATION
Education
Fellowship – Nephrology
1998
·
Beth Israel Deaconess Medical Center
Residency – Internal Medicine
1995
·
Parkland Memorial Hospital
Internship – Internal Medicine
1993
·
Parkland Memorial Hospital
Medical Degree
1992
·
University of Southwestern
Bachelor of Science
1984
·
Massachusetts Institute of Technology (MIT)
Contact Details
Phones:
- Business:
- (352) 273-8821
Emails:
- Business:
- segalms@medicine.ufl.edu
Addresses:
- Business Mailing:
-
1600 Archer Road
M100
GAINESVILLE FL 326100224 - Business Street:
-
PO Box 100224
GAINESVILLE FL 32610