Michelle L Gumz

Michelle L Gumz,

Associate Professor

Department: MD-PHYSIOLOGY FUNCTIONAL GENOM
Business Phone: (352) 273-6887

Teaching Profile

Courses Taught
2013,2020
BCH6208 Advanced Metabolism: Regulation of Key Reactions in Carbohydrate and Lipid Metabolism
2015-2023
GMS6491 Journal Club in Physiology
2020
BCH6207 Advanced Metabolism: Role of Membranes in Signal Transduction and Metabolic Control
2013-2018,2020-2021
BCH6206 Advanced Metabolism
2013-2023
BCH5413 Mammalian Molecular Biology and Genetics
2013-2014,2016-2021,2020-2021
BCH4905 Biochemistry Senior Research
2014-2019,2021-2023
BCH6415 Advanced Molecular and Cell Biology
2018
GMS7980 Research for Doctoral Dissertation
2018
BMS6638C Kidney & Urinary Tract
2014-2015
BCH6209 Advanced Metabolism: Regulation of Key Reactions in Amino Acid and Nucleotide Metabolism
2021
VME6934 Topics in Veterinary Medical Sciences

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-1342-0878

Publications

2022
A wrinkle in time: circadian biology in pulmonary vascular health and disease
American Journal of Physiology-Lung Cellular and Molecular Physiology. 322(1):L84-L101 [DOI] 10.1152/ajplung.00037.2021. [PMID] 34850650.
2022
Apparent Absence of BMAL1-Dependent Skeletal Muscle-Kidney Cross Talk in Mice.
Biomolecules. 12(2) [DOI] 10.3390/biom12020261. [PMID] 35204763.
2022
Circadian Clocks of the Kidney: Function, Mechanism, and Regulation.
Physiological reviews. [DOI] 10.1152/physrev.00045.2021. [PMID] 35575250.
2022
Circadian rhythms and renal pathophysiology
Journal of Clinical Investigation. 132(3) [DOI] 10.1172/jci148277.
2022
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression
American Journal of Physiology-Renal Physiology. 322(4):F449-F459 [DOI] 10.1152/ajprenal.00385.2021. [PMID] 35129370.
2021
Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.
Comprehensive Physiology. 12(1):2769-2798 [DOI] 10.1002/cphy.c210011. [PMID] 34964116.
2021
Circadian Rhythm, Clock Genes, and Hypertension: Recent Advances in Hypertension
Hypertension. 78(5):1185-1196 [DOI] 10.1161/hypertensionaha.121.14519.
2021
Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats.
American journal of physiology. Renal physiology. 320(2):F224-F233 [DOI] 10.1152/ajprenal.00421.2020. [PMID] 33356955.
2021
Interplay of the Circadian Clock and Endothelin System.
Physiology (Bethesda, Md.). 36(1):35-43 [DOI] 10.1152/physiol.00021.2020. [PMID] 33325818.
2021
Likelihood-based tests for detecting circadian rhythmicity and differential circadian patterns in transcriptomic applications.
Briefings in bioinformatics. 22(6) [DOI] 10.1093/bib/bbab224. [PMID] 34117739.
2020
Circadian clock genes and respiratory neuroplasticity genes oscillate in the phrenic motor system.
American journal of physiology. Regulatory, integrative and comparative physiology. 318(6):R1058-R1067 [DOI] 10.1152/ajpregu.00010.2020. [PMID] 32348679.
2020
Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice.
American journal of physiology. Renal physiology. 318(6):F1463-F1477 [DOI] 10.1152/ajprenal.00014.2020. [PMID] 32338037.
2020
EDN1-AS, A Novel Long Non-coding RNA Regulating Endothelin-1 in Human Proximal Tubule Cells.
Frontiers in physiology. 11 [DOI] 10.3389/fphys.2020.00209. [PMID] 32231591.
2020
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
Canadian journal of physiology and pharmacology. 98(9):579-586 [DOI] 10.1139/cjpp-2019-0688. [PMID] 32437627.
2019
Circadian Clock Genes in Diabetic Kidney Disease (DKD).
Current diabetes reports. 19(7) [DOI] 10.1007/s11892-019-1156-z. [PMID] 31168658.
2019
Clock gene expression is altered in veterans with sleep apnea.
Physiological genomics. 51(3):77-82 [DOI] 10.1152/physiolgenomics.00091.2018. [PMID] 30657733.
2019
Direct and indirect inhibition of the circadian clock protein Per1: effects on ENaC and blood pressure.
American journal of physiology. Renal physiology. 316(5):F807-F813 [DOI] 10.1152/ajprenal.00408.2018. [PMID] 30759025.
2019
Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology. 316(1):R50-R58 [DOI] 10.1152/ajpregu.00381.2017. [PMID] 30427705.
2018
Circadian clock-mediated regulation of blood pressure.
Free radical biology & medicine. 119:108-114 [DOI] 10.1016/j.freeradbiomed.2017.11.024. [PMID] 29198725.
2018
Clocking skin sodium.
American journal of physiology. Regulatory, integrative and comparative physiology. 314(4):R542-R543 [DOI] 10.1152/ajpregu.00453.2017. [PMID] 29351424.
2018
Predicted effect of circadian clock modulation of NHE3 of a proximal tubule cell on sodium transport.
American journal of physiology. Renal physiology. 315(3):F665-F676 [DOI] 10.1152/ajprenal.00008.2018. [PMID] 29537313.
2018
RECENT ADVANCES IN UNDERSTANDING THE CIRCADIAN CLOCK IN RENAL PHYSIOLOGY.
Current opinion in physiology. 5:38-44 [DOI] 10.1016/j.cophys.2018.06.002. [PMID] 30714020.
2018
Renal and colonic potassium transporters in the pregnant rat.
American journal of physiology. Renal physiology. 314(2):F251-F259 [DOI] 10.1152/ajprenal.00288.2017. [PMID] 29046297.
2018
Renal Na-handling defect associated with PER1-dependent nondipping hypertension in male mice.
American journal of physiology. Renal physiology. 314(6):F1138-F1144 [DOI] 10.1152/ajprenal.00546.2017. [PMID] 29357420.
2017
Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice.
Acta physiologica (Oxford, England). 220(1):72-82 [DOI] 10.1111/apha.12804. [PMID] 27636900.
2017
ENaC activity in the cortical collecting duct of HKα1 H+,K+-ATPase knockout mice is uncoupled from Na+ intake.
American journal of physiology. Renal physiology. 312(6):F1073-F1080 [DOI] 10.1152/ajprenal.00401.2016. [PMID] 28179253.
2016
Aldosterone alters the chromatin structure of the murine endothelin-1 gene.
Life sciences. 159:121-126 [DOI] 10.1016/j.lfs.2016.01.019. [PMID] 26775567.
2016
How to Find More Hours in the Day.
The Physiologist. 59(3):127-9 [PMID] 27266014.
2016
Molecular basis of circadian rhythmicity in renal physiology and pathophysiology.
Experimental physiology. 101(8):1025-9 [DOI] 10.1113/EP085781. [PMID] 27474264.
2016
Taking into account circadian rhythm when conducting experiments on animals.
American journal of physiology. Renal physiology. 310(6):F454-5 [DOI] 10.1152/ajprenal.00549.2015. [PMID] 26719365.
2015
An Integrated View of Potassium Homeostasis.
The New England journal of medicine. 373(18):1787-8 [DOI] 10.1056/NEJMc1509656. [PMID] 26510039.
2015
An Integrated View of Potassium Homeostasis.
The New England journal of medicine. 373(1):60-72 [DOI] 10.1056/NEJMra1313341. [PMID] 26132942.
2015
Effect of mineralocorticoid treatment in mice with collecting duct-specific knockout of endothelin-1.
American journal of physiology. Renal physiology. 309(12):F1026-34 [DOI] 10.1152/ajprenal.00220.2015. [PMID] 26400543.
2015
The Circadian Clock in the Regulation of Renal Rhythms.
Journal of biological rhythms. 30(6):470-86 [DOI] 10.1177/0748730415610879. [PMID] 26527094.
2015
Transcriptional regulation of NHE3 and SGLT1 by the circadian clock protein Per1 in proximal tubule cells.
American journal of physiology. Renal physiology. 309(11):F933-42 [DOI] 10.1152/ajprenal.00197.2014. [PMID] 26377793.
2014
A Role for the Circadian Clock Protein Per1 in the Regulation of Nhe3 and Sglt1 in Human Proximal Tubule Cells
The FASEB's Journal. 28(1, S)
2014
A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells.
The Journal of biological chemistry. 289(17):11791-11806 [DOI] 10.1074/jbc.M113.531095. [PMID] 24610784.
2014
Clock genes in hypertension: novel insights from rodent models.
Blood pressure monitoring. 19(5):249-54 [DOI] 10.1097/MBP.0000000000000060. [PMID] 25025868.
2014
Molecular origin of the kidney clock.
Kidney international. 86(5):873-4 [DOI] 10.1038/ki.2014.239. [PMID] 25360489.
2014
Renal Potassium Handling in the Pregnant Rat
The FASEB's Journal. 28(1, S)
2014
Tick tock: time to recognize the kidney clock.
Journal of the American Society of Nephrology : JASN. 25(7):1369-71 [DOI] 10.1681/ASN.2014020199. [PMID] 24652798.
2014
Tissue-specific and time-dependent regulation of the endothelin axis by the circadian clock protein Per1.
Life sciences. 118(2):255-62 [DOI] 10.1016/j.lfs.2014.03.028. [PMID] 24721511.
2013
A role for the circadian clock protein Per1 in the regulation of aldosterone levels and renal Na+ retention.
American journal of physiology. Renal physiology. 305(12):F1697-704 [DOI] 10.1152/ajprenal.00472.2013. [PMID] 24154698.
2013
Mechanism of Per1 Action in Blood Pressure Control: Role of the Circadian Repressor Cry 2
The FASEB's Journal. 27
2013
Mechanism of the circadian clock in physiology.
American journal of physiology. Regulatory, integrative and comparative physiology. 304(12):R1053-64 [DOI] 10.1152/ajpregu.00066.2013. [PMID] 23576606.
2013
Molecular bases of circadian rhythmicity in renal physiology and pathology.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 28(10):2421-31 [DOI] 10.1093/ndt/gft319. [PMID] 23901050.
2013
Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney.
American journal of physiology. Regulatory, integrative and comparative physiology. 305(7):R735-47 [DOI] 10.1152/ajpregu.00195.2013. [PMID] 23824961.
2013
Role of circadian rhythms in potassium homeostasis.
Seminars in nephrology. 33(3):229-36 [DOI] 10.1016/j.semnephrol.2013.04.003. [PMID] 23953800.
2013
Role of Per1 and the mineralocorticoid receptor in the coordinate regulation of αENaC in renal cortical collecting duct cells.
Frontiers in physiology. 4 [DOI] 10.3389/fphys.2013.00253. [PMID] 24062694.
2012
Advances in understanding the peripheral circadian clocks.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 26(9):3602-13 [DOI] 10.1096/fj.12-203554. [PMID] 22661008.
2012
Dexamethasone stimulates endothelin-1 gene expression in renal collecting duct cells.
Steroids. 77(5):360-6 [DOI] 10.1016/j.steroids.2011.12.011. [PMID] 22209709.
2012
Inhibition of Alpha Enac Expression and Enac Activity Following Blockade of the Circadian Clock-Regulatory Kinases Cki Delta/Epsilon
The FASEB's Journal. 26
2012
Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε.
American journal of physiology. Renal physiology. 303(7):F918-27 [DOI] 10.1152/ajprenal.00678.2011. [PMID] 22832921.
2012
The circadian protein period 1 contributes to blood pressure control and coordinately regulates renal sodium transport genes.
Hypertension (Dallas, Tex. : 1979). 59(6):1151-6 [DOI] 10.1161/HYPERTENSIONAHA.112.190892. [PMID] 22526258.
2011
Mineralocorticoids stimulate the activity and expression of renal H+,K+-ATPases.
Journal of the American Society of Nephrology : JASN. 22(1):49-58 [DOI] 10.1681/ASN.2010030311. [PMID] 21164026.
2011
The circadian clock in the kidney.
Journal of the American Society of Nephrology : JASN. 22(4):598-604 [DOI] 10.1681/ASN.2010080803. [PMID] 21436284.
2010
Heterogeneity of H-K-ATPase-mediated acid secretion along the mouse collecting duct.
American journal of physiology. Renal physiology. 298(2):F408-15 [DOI] 10.1152/ajprenal.00333.2009. [PMID] 19923411.
2010
Pharmacological profiles of the murine gastric and colonic H,K-ATPases.
Biochimica et biophysica acta. 1800(9):906-11 [DOI] 10.1016/j.bbagen.2010.05.002. [PMID] 20594946.
2010
Regulation of αENaC expression by the circadian clock protein Period 1 in mpkCCD(c14) cells.
Biochimica et biophysica acta. 1799(9):622-9 [DOI] 10.1016/j.bbagrm.2010.09.003. [PMID] 20868778.
2010
The renal H+-K+-ATPases: physiology, regulation, and structure.
American journal of physiology. Renal physiology. 298(1):F12-21 [DOI] 10.1152/ajprenal.90723.2008. [PMID] 19640897.
2010
The renal H,K-ATPases.
Current opinion in nephrology and hypertension. 19(5):478-82 [DOI] 10.1097/MNH.0b013e32833ce65f. [PMID] 20616716.
2009
Aldosterone modulates steroid receptor binding to the endothelin-1 gene (edn1).
The Journal of biological chemistry. 284(44):30087-96 [DOI] 10.1074/jbc.M109.030718. [PMID] 19638349.
2009
Reactivation of suppressed RhoB is a critical step for the inhibition of anaplastic thyroid cancer growth.
Cancer research. 69(4):1536-44 [DOI] 10.1158/0008-5472.CAN-08-3718. [PMID] 19208833.
2009
The circadian clock protein Period 1 regulates expression of the renal epithelial sodium channel in mice.
The Journal of clinical investigation. 119(8):2423-34 [DOI] 10.1172/JCI36908. [PMID] 19587447.
2007
Secreted frizzled-related protein 1 loss contributes to tumor phenotype of clear cell renal cell carcinoma.
Clinical cancer research : an official journal of the American Association for Cancer Research. 13(16):4740-9 [PMID] 17699851.
2007
The renal H+, K+-ATPases as therapeutic targets.
Expert opinion on therapeutic targets. 11(7):881-90 [PMID] 17614757.
2006
Characterization of the rabbit HKalpha2 gene promoter.
Biochimica et biophysica acta. 1759(10):443-50 [PMID] 17034876.
2006
Molecular diagnosis of a BRAF papillary thyroid carcinoma with multiple chromosome abnormalities and rare adrenal and hypothalamic metastases.
Thyroid : official journal of the American Thyroid Association. 16(12):1293-302 [PMID] 17199440.
2003
Early transcriptional effects of aldosterone in a mouse inner medullary collecting duct cell line.
American journal of physiology. Renal physiology. 285(4):F664-73 [PMID] 12770840.
2003
Molecular modeling of the rabbit colonic (HKalpha2a) H+, K+ ATPase.
Journal of molecular modeling. 9(5):283-9 [PMID] 12884085.
Defining the age-dependent and tissue-specific circadian transcriptome in male mice
. [DOI] 10.1101/2022.04.27.489594.

Grants

Jan 2022 ACTIVE
Contribution of the adrenal clock to renal function
Role: Other
Funding: AMER HEART ASSOCIATION
Dec 2021 ACTIVE
Vanderbilt O'Brien Kidney Center
Role: Principal Investigator
Funding: VANDERBILT UNIVERSITY MEDICAL CENTER via NATL INST OF HLTH NIDDK
Nov 2021 ACTIVE
Regulation of sodium handling by Bmal1 under dietary potassium restriction
Role: Other
Funding: AMER HEART ASSOCIATION
Sep 2021 ACTIVE
Modulation of the renal aldosterone endothelin feedback system by the clock protein PER1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
May 2021 ACTIVE
Endothelial Circadian Clock Protein PER1 Modulates Salt-sensitive Hypertension
Role: Co-Investigator
Funding: FL DEPT OF HLTH BIOMED RES PGM/J&E KING
May 2021 ACTIVE
ADAPT: Autonomous Delirium Monitoring and Adaptive Prevention
Role: Co-Investigator
Funding: NATL INST OF HLTH NINDS
Apr 2021 ACTIVE
Centrifugal regulation of olfactory function by melanin-concentrating hormone
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDCD
Jul 2020 ACTIVE
The circadian clock protein BMAL and post-translational regulation of ENaC in the kidney
Role: Co-Investigator
Funding: NATL INST OF HLTH NIDDK
Mar 2020 – Mar 2022
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation in Male and Female Mice
Role: Other
Funding: NATL INST OF HLTH NIDDK
Jul 2019 ACTIVE
Kidney-Specific and Sex-Dependent Regulation of Blood Pressure by the Circadian Clock Protein BMAL1
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jan 2019 – Mar 2020
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation
Role: Other
Funding: AMER HEART ASSOCIATION
Jul 2018 – Jun 2020
Mechanism of Per1-Dependent Salt-Sensitive Non-Dipping Hypertension
Role: Other
Funding: AMER HEART ASSOCIATION
Sep 2017 ACTIVE
Per1 and the kidney clock in hypertension
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Apr 2017 – Mar 2022
University of Florida Claude D. Pepper Older Americans Independence Center (OAIC)
Role: Project Manager
Funding: NATL INST OF HLTH NIA
Dec 2016 – Nov 2019
Novel mechanism to target the endothelin axis in aging and CKD
Role: Principal Investigator
Funding: NATL INST OF HLTH NIA
Jul 2016 – Jun 2018
Blood Pressure regulation by per1 and the kidney clock
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Jul 2013 – Dec 2016
Role of the Kidney in Blood Pressure Regulation by the Circadian Protein Per1
Role: Principal Investigator
Funding: AMER SOC OF NEPHROLOGY
Apr 2013 – Mar 2017
Blood Pressure Regulation by the Circadian Clock Protein Per1
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK

Contact Details

Phones:
Business:
(352) 273-6887
Emails:
Addresses:
Business Mailing:
PO Box 100224
GAINESVILLE FL 32610
Business Street:
PO Box 100224
GAINESVILLE FL 32610