Gene R Crislip

Gene R Crislip, PhD

Research Assistant Professor

Department: Department of Physiology and Aging
Business Phone: (352) 294-5486
Business Email: gcrislip@ufl.edu

About Gene R Crislip

My research focus throughout my career has centered around renal physiology and cardiovascular diseases. As a graduate student at the Medical College of Georgia, my studies examined sex differences in renal ischemia reperfusion injury and blood pressure control. My main project was to determine the role of renal medullary pericytes following ischemia reperfusion in both males and females. We were able to produce data demonstrating a link between medullary pericytes and ischemia-reperfusion-induced vascular congestion. I joined the University of Florida as a postdoctoral fellow. The topic of my research during this time was to examine the role of distal nephron-specific BMAL1 in blood pressure control in males and females. BMAL1 is a core circadian clock factor that has been linked to blood pressure control previously. We were able to demonstrate that manipulation of dietary potassium exacerbated the genotype-specific difference in blood pressure found in males. Currently, I am interested in the contribution of the circadian clock to the immune response within the kidney.

Teaching Profile

Courses Taught
2022-2025
GMS6491 Journal Club in Physiology

Research Profile

Open Researcher and Contributor ID (ORCID)

0000-0002-9528-1057

Publications

2023
Adrenal-Specific KO of the Circadian Clock Protein BMAL1 Alters Blood Pressure Rhythm and Timing of Eating Behavior.
Function (Oxford, England). 4(2) [DOI] 10.1093/function/zqad001. [PMID] 36778748.
2023
Defining the age-dependent and tissue-specific circadian transcriptome in male mice.
Cell reports. 42(1) [DOI] 10.1016/j.celrep.2022.111982. [PMID] 36640301.
2023
Male kidney-specific BMAL1 knockout mice are protected from K+-deficient, high-salt diet-induced blood pressure increases.
American journal of physiology. Renal physiology. 325(5):F656-F668 [DOI] 10.1152/ajprenal.00126.2023. [PMID] 37706232.
2023
The circadian clock protein PER1 is important in maintaining endothelin axis regulation in Dahl salt-sensitive rats.
Canadian journal of physiology and pharmacology. 101(3):136-146 [DOI] 10.1139/cjpp-2022-0134. [PMID] 36450128.
2022
Apparent Absence of BMAL1-Dependent Skeletal Muscle-Kidney Cross Talk in Mice.
Biomolecules. 12(2) [DOI] 10.3390/biom12020261. [PMID] 35204763.
2022
Circadian clocks of the kidney: function, mechanism, and regulation.
Physiological reviews. 102(4):1669-1701 [DOI] 10.1152/physrev.00045.2021. [PMID] 35575250.
2022
Kidney-specific KO of the circadian clock protein PER1 alters renal Na+ handling, aldosterone levels, and kidney/adrenal gene expression.
American journal of physiology. Renal physiology. 322(4):F449-F459 [DOI] 10.1152/ajprenal.00385.2021. [PMID] 35129370.
2022
Knockout of the Circadian Clock Protein PER1 (Period1) Exacerbates Hypertension and Increases Kidney Injury in Dahl Salt-Sensitive Rats.
Hypertension (Dallas, Tex. : 1979). 79(11):2519-2529 [DOI] 10.1161/HYPERTENSIONAHA.122.19316. [PMID] 36093781.
2022
Persistent vascular congestion in male spontaneously hypertensive rats contributes to delayed recovery of renal function following renal ischemia perfusion compared with females.
Clinical science (London, England : 1979). 136(11):825-840 [DOI] 10.1042/CS20220002. [PMID] 35535709.
2021
Circadian Rhythm Effects on the Molecular Regulation of Physiological Systems.
Comprehensive Physiology. 12(1):2769-2798 [DOI] 10.1002/cphy.c210011. [PMID] 34964116.
2021
Environmental circadian disruption suppresses rhythms in kidney function and accelerates excretion of renal injury markers in urine of male hypertensive rats.
American journal of physiology. Renal physiology. 320(2):F224-F233 [DOI] 10.1152/ajprenal.00421.2020. [PMID] 33356955.
2020
Differences in renal BMAL1 contribution to Na+ homeostasis and blood pressure control in male and female mice.
American journal of physiology. Renal physiology. 318(6):F1463-F1477 [DOI] 10.1152/ajprenal.00014.2020. [PMID] 32338037.
2020
Greater T Regulatory Cells in Females Attenuate DOCA-Salt-Induced Increases in Blood Pressure Versus Males.
Hypertension (Dallas, Tex. : 1979). 75(6):1615-1623 [DOI] 10.1161/HYPERTENSIONAHA.119.14089. [PMID] 32336228.
2020
Knockout of the circadian clock protein PER1 results in sex-dependent alterations of ET-1 production in mice in response to a high-salt diet plus mineralocorticoid treatment.
Canadian journal of physiology and pharmacology. 98(9):579-586 [DOI] 10.1139/cjpp-2019-0688. [PMID] 32437627.
2020
Ultrasound measurement of change in kidney volume is a sensitive indicator of severity of renal parenchymal injury.
American journal of physiology. Renal physiology. 319(3):F447-F457 [DOI] 10.1152/ajprenal.00221.2020. [PMID] 32686518.
2019
Female C57BL/6J mice lacking the circadian clock protein PER1 are protected from nondipping hypertension.
American journal of physiology. Regulatory, integrative and comparative physiology. 316(1):R50-R58 [DOI] 10.1152/ajpregu.00381.2017. [PMID] 30427705.
2019
Galectin-3 is expressed in vascular smooth muscle cells and promotes pulmonary hypertension through changes in proliferation, apoptosis, and fibrosis.
American journal of physiology. Lung cellular and molecular physiology. 316(5):L784-L797 [DOI] 10.1152/ajplung.00186.2018. [PMID] 30724100.
2018
RECENT ADVANCES IN UNDERSTANDING THE CIRCADIAN CLOCK IN RENAL PHYSIOLOGY.
Current opinion in physiology. 5:38-44 [DOI] 10.1016/j.cophys.2018.06.002. [PMID] 30714020.
2018
Sodium bicarbonate loading limits tubular cast formation independent of glomerular injury and proteinuria in Dahl salt-sensitive rats.
Clinical science (London, England : 1979). 132(11):1179-1197 [DOI] 10.1042/CS20171630. [PMID] 29650676.
2017
Greater transforming growth factor-β in adult female SHR is dependent on blood pressure, but does not account for sex differences in renal T-regulatory cells.
American journal of physiology. Renal physiology. 313(4):F847-F853 [DOI] 10.1152/ajprenal.00175.2017. [PMID] 28679591.
2017
Vasa recta pericyte density is negatively associated with vascular congestion in the renal medulla following ischemia reperfusion in rats.
American journal of physiology. Renal physiology. 313(5):F1097-F1105 [DOI] 10.1152/ajprenal.00261.2017. [PMID] 28794065.
2016
T-cell involvement in sex differences in blood pressure control.
Clinical science (London, England : 1979). 130(10):773-83 [DOI] 10.1042/CS20150620. [PMID] 27128802.
2015
Blood pressure, sex, and female sex hormones influence renal inner medullary nitric oxide synthase activity and expression in spontaneously hypertensive rats.
Journal of the American Heart Association. 4(4) [DOI] 10.1161/JAHA.114.001738. [PMID] 25862792.
2013
Female SHR have greater blood pressure sensitivity and renal T cell infiltration following chronic NOS inhibition than males.
American journal of physiology. Regulatory, integrative and comparative physiology. 305(7):R701-10 [DOI] 10.1152/ajpregu.00226.2013. [PMID] 23883679.
2012
Use of ultrasound to assess renal reperfusion and P-selectin expression following unilateral renal ischemia.
American journal of physiology. Renal physiology. 303(9):F1333-40 [DOI] 10.1152/ajprenal.00406.2012. [PMID] 22933301.

Grants

Feb 2024 ACTIVE
Renal Circadian Clock Protein Regulation of Immune Activation
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jul 2023 ACTIVE
Renal Circadian Clock Protein Regulation of the Immune Response in Aging
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION
Mar 2023 ACTIVE
Sex differences in the kidney circadian clock mechanism
Role: Co-Investigator
Funding: AUGUSTA UNIVERSITY via NATL INST OF HLTH NIDDK
Mar 2020 – Mar 2022
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation in Male and Female Mice
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jan 2019 – Mar 2020
The Role of Sex Hormones in Distal Nephron-Specific BMAL1 Blood Pressure Regulation
Role: Principal Investigator
Funding: AMER HEART ASSOCIATION

Contact Details

Phones:
Business:
(352) 294-5486
Emails:
Business:
gcrislip@ufl.edu
Addresses:
Business Mailing:
PO Box 100274 M554
1345 CENTER DR
GAINESVILLE FL 32610
Business Street:
POBOX 100274
1345 Center Drive # M554
GAINESVILLE FL 32610