Dr. Kelly Hyndman has long been fascinated by how the body maintains fluid and electrolyte balance in an ever-changing environment. From studying fishes that migrate between freshwater and seawater to investigating how humans adapt to high dietary sodium intake, her research uses basic science models to uncover the mechanisms that regulate fluid and electrolyte homeostasis. Dr. Hyndman earned her Ph.D. in Zoology from the University of Florida under the mentorship of Dr. David Evans, where she explored the evolution and physiology of the endothelin system in fishes. She then completed postdoctoral training at the Medical College of Georgia with Dr. Jennifer Pollock, testing the hypothesis that endothelin and nitric oxide interact in the kidney to promote salt excretion. Her work demonstrated that disruption of either pathway leads to salt-sensitive hypertension. As a principal investigator, Dr. Hyndman leads research in three main areas:
* Defining the physiology and regulatory mechanisms of lysine acetylation in the kidney and its role in fluid-electrolyte balance.
* Investigating how dysregulation of epigenetic pathways contributes to acute kidney injury and chronic kidney disease progression.
* Applying multi-omics approaches to identify novel regulatory mechanisms in the kidney during repeated dehydration and heat stress induced kidney injury.
Dr. Hyndman is currently funded by multiple NIH grants and has authored more than 60 peer-reviewed publications. She serves as Co-Associate Director of the Nephrology Research and Training Center at UAB and chairs the American Physiological Society Renal Section Awards Committee. In addition, she is a standing member of the NIH PBKD Study Section and the Senior Editor of the Canadian Journal of Physiology and Pharmacology.
Learn More: https://cicmd.center.ufl.edu/center-activities/cicmd-past-and-future-seminar-series/
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