I. D Weiner

I. D Weiner, M.D.

Professor Of Medicine & Physiology

Department: MD-NEPHROLOGY
Business Phone: (352) 273-5358

About I. D Weiner

I. David Weiner, M.D., is Professor of Medicine and Physiology and Functional Genomics in the Division of Nephrology, Hypertension and Renal Transplantation at the University of Florida, and he is a co-holder of the C. Craig and Audrae Tisher Chair in Nephrology. Dr. Weiner is also Chief of the Nephrology and Hypertension Section of the North Florida/South Georgia Veterans Health System.

Dr. Weiner has an active clinical practice, and he directs an NIH-, VA- and AHA-funded research program.

His major administrative roles have included serving as interim clinical chief of the Division of Nephrology, Hypertension and Renal Transplantation, director of the nephrology fellowship program at the University of Florida, chair-person of the Shands Hospital Pharmacy and Therapeutics Committee, Co-director of the MS2 Nephrology Course for the University of Florida College of Medicine, member and chair-person of the Department of Veterans Affairs Merit Review Subcommittee for Nephrology, standing member of the NIH Kidney Molecular Biology and Genitourinary Development committee, and director of the Division of Nephrology, Hypertension and Renal Transplantation outpatient clinic program.

Teaching Profile

Courses Taught
2015,2018
BMS6638C Kidney & Urinary Tract

Board Certifications

  • Internal Medicine
    American Board of Internal Medicine
  • Nephrology
    American Board of Internal Medicine

Clinical Profile

Areas of Interest
  • Acute kidney failure
  • Chronic kidney disease
  • Diabetes and kidney disease
  • Diet – chronic kidney disease
  • Electrolytes
  • Genetics
  • Hypokalemic periodic paralysis
  • Malignant hypertension
  • Polycystic kidney disease
  • Primary and secondary hyperaldosteronism
  • Renovascular hypertension

Research Profile

Dr. Weiner’s pre-clinical research interests focus on the molecular mechanisms and the regulation of acid-base hemostasis. This includes studies on ammonia metabolism, including regulation of production and novel mechanisms of transport by specific proteins. Dr. Weiner’s laboratory played a major role in a recognition the Rhesus glycoproteins enable regulated transport of ammonia gas, NH3, which resulted in a paradigm shift shift in the understanding of ammonia metabolism.

Open Researcher and Contributor ID (ORCID)

0000-0002-0046-0600

Publications

2022
Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B
American Journal of Physiology-Renal Physiology. 322(2):F208-F224 [DOI] 10.1152/ajprenal.00358.2021. [PMID] 35001662.
2021
Regulation of Rhcg, an ammonia transporter, by aldosterone in the kidney.
The Journal of endocrinology. 249(2):95-112 [DOI] 10.1530/JOE-20-0267. [PMID] 33705345.
2021
Role of the renal androgen receptor in sex differences in ammonia metabolism
American Journal of Physiology-Renal Physiology. 321(5):F629-F644 [DOI] 10.1152/ajprenal.00260.2021. [PMID] 34605272.
2021
Sex differences in renal ammonia metabolism
American Journal of Physiology-Renal Physiology. 320(1):F55-F60 [DOI] 10.1152/ajprenal.00531.2020. [PMID] 33308019.
2020
NBCe1-A is required for the renal ammonia and K+ response to hypokalemia
American Journal of Physiology-Renal Physiology. 318(2):F402-F421 [DOI] 10.1152/ajprenal.00481.2019. [PMID] 31841393.
2020
Prevalence and correlates of sleep apnea among US Veterans with chronic kidney disease.
Journal of sleep research. 29(4) [DOI] 10.1111/jsr.12981. [PMID] 31912641.
2020
Testosterone modulates renal ammonia metabolism
American Journal of Physiology-Renal Physiology. 318(4):F922-F935 [DOI] 10.1152/ajprenal.00560.2019. [PMID] 32116019.
2019
Clock gene expression is altered in veterans with sleep apnea
Physiological Genomics. 51(3):77-82 [DOI] 10.1152/physiolgenomics.00091.2018. [PMID] 30657733.
2019
Differences in acidosis-stimulated renal ammonia metabolism in the male and female kidney
American Journal of Physiology-Renal Physiology. 317(4):F890-F905 [DOI] 10.1152/ajprenal.00244.2019. [PMID] 31390234.
2019
Emerging Features of Ammonia Metabolism and Transport in Acid-Base Balance.
Seminars in nephrology. 39(4):394-405 [DOI] 10.1016/j.semnephrol.2019.04.008. [PMID] 31300094.
2019
Ethanol sensitizes skeletal muscle to ammonia-induced molecular perturbations.
The Journal of biological chemistry. 294(18):7231-7244 [DOI] 10.1074/jbc.RA118.005411. [PMID] 30872403.
2019
Regulation of renal NaDC1 expression and citrate excretion by NBCe1-A
American Journal of Physiology-Renal Physiology. 317(2):F489-F501 [DOI] 10.1152/ajprenal.00015.2019. [PMID] 31188034.
2018
Differences in renal ammonia metabolism in male and female kidney
American Journal of Physiology-Renal Physiology. 315(2):F211-F222 [DOI] 10.1152/ajprenal.00084.2018. [PMID] 29561185.
2018
Expression of the B splice variant of NBCe1 (SLC4A4) in the mouse kidney
American Journal of Physiology-Renal Physiology. 315(3):F417-F428 [DOI] 10.1152/ajprenal.00515.2017. [PMID] 29631353.
2018
Mechanism of Hyperkalemia-Induced Metabolic Acidosis
Journal of the American Society of Nephrology. 29(5):1411-1425 [DOI] 10.1681/asn.2017111163.
2018
Mechanism of Hyperkalemia-Induced Metabolic Acidosis
Journal of the American Society of Nephrology. 29(5):1411-1425 [DOI] 10.1681/asn.2017111163.
2018
NBCe1-A Regulates Proximal Tubule Ammonia Metabolism under Basal Conditions and in Response to Metabolic Acidosis
Journal of the American Society of Nephrology. 29(4):1182-1197 [DOI] 10.1681/asn.2017080935.
2018
NBCe1-A Regulates Proximal Tubule Ammonia Metabolism under Basal Conditions and in Response to Metabolic Acidosis
Journal of the American Society of Nephrology. 29(4):1182-1197 [DOI] 10.1681/asn.2017080935.
2017
Ammonia Transporters and Their Role in Acid-Base Balance
Physiological Reviews. 97(2):465-494 [DOI] 10.1152/physrev.00011.2016. [PMID] 28151423.
2017
Expression of sodium-dependent dicarboxylate transporter 1 (NaDC1/SLC13A2) in normal and neoplastic human kidney
American Journal of Physiology-Renal Physiology. 312(3):F427-F435 [DOI] 10.1152/ajprenal.00559.2016. [PMID] 27927654.
2017
Polymorphisms in Renal Ammonia Metabolism Genes Correlate With 24-Hour Urine pH.
Kidney international reports. 2(6):1111-1121 [DOI] 10.1016/j.ekir.2017.06.009. [PMID] 29270519.
2017
Proximal tubule glutamine synthetase expression is necessary for the normal response to dietary protein restriction
American Journal of Physiology-Renal Physiology. 313(1):F116-F125 [DOI] 10.1152/ajprenal.00048.2017. [PMID] 28331060.
2017
Roles of renal ammonia metabolism other than in acid-base homeostasis.
Pediatric nephrology (Berlin, Germany). 32(6):933-942 [DOI] 10.1007/s00467-016-3401-x. [PMID] 27169421.
2016
Effect of NBCe1 deletion on renal citrate and 2-oxoglutarate handling.
Physiological reports. 4(8) [DOI] 10.14814/phy2.12778. [PMID] 27117802.
2016
Hydration status affects osteopontin expression in the rat kidney.
Journal of veterinary science. 17(3):269-77 [DOI] 10.4142/jvs.2016.17.3.269. [PMID] 26645343.
2016
New insights into the molecular regulation of urine concentration
American Journal of Physiology-Renal Physiology. 311(1):F184-F185 [DOI] 10.1152/ajprenal.00161.2016. [PMID] 27029426.
2016
Proximal tubule-specific glutamine synthetase deletion alters basal and acidosis-stimulated ammonia metabolism
American Journal of Physiology-Renal Physiology. 310(11):F1229-F1242 [DOI] 10.1152/ajprenal.00547.2015. [PMID] 27009341.
2016
Recent advances in understanding renal ammonia metabolism and transport.
Current opinion in nephrology and hypertension. 25(5):436-43 [DOI] 10.1097/MNH.0000000000000255. [PMID] 27367914.
2016
Untangling the complex relationship between dietary acid load and glucocorticoid metabolism.
Kidney international. 90(2):247-249 [DOI] 10.1016/j.kint.2016.04.011. [PMID] 27418088.
2015
Effect of dietary protein restriction on renal ammonia metabolism
American Journal of Physiology-Renal Physiology. 308(12):F1463-F1473 [DOI] 10.1152/ajprenal.00077.2015. [PMID] 25925252.
2015
NBCe1 expression is required for normal renal ammonia metabolism
American Journal of Physiology-Renal Physiology. 309(7):F658-F666 [DOI] 10.1152/ajprenal.00219.2015. [PMID] 26224717.
2015
Urea and Ammonia Metabolism and the Control of Renal Nitrogen Excretion.
Clinical journal of the American Society of Nephrology : CJASN. 10(8):1444-58 [DOI] 10.2215/CJN.10311013. [PMID] 25078422.
2014
Ammonia transport in the kidney by Rhesus glycoproteins.
American journal of physiology. Renal physiology. 306(10):F1107-20 [DOI] 10.1152/ajprenal.00013.2014. [PMID] 24647713.
2014
Effect of collecting duct-specific deletion of both Rh B Glycoprotein (Rhbg) and Rh C Glycoprotein (Rhcg) on renal response to metabolic acidosis.
American journal of physiology. Renal physiology. 306(4):F389-400 [DOI] 10.1152/ajprenal.00176.2013. [PMID] 24338819.
2014
Effects of chronic lithium administration on renal acid excretion in humans and rats.
Physiological reports. 2(12) [DOI] 10.14814/phy2.12242. [PMID] 25501430.
2013
Endocrine and hypertensive disorders of potassium regulation: primary aldosteronism.
Seminars in nephrology. 33(3):265-76 [DOI] 10.1016/j.semnephrol.2013.04.007. [PMID] 23953804.
2013
Expression of glutamine synthetase in the mouse kidney: localization in multiple epithelial cell types and differential regulation by hypokalemia.
American journal of physiology. Renal physiology. 305(5):F701-13 [DOI] 10.1152/ajprenal.00030.2013. [PMID] 23804452.
2013
Expression of the ammonia transporter family member, Rh B Glycoprotein, in the human kidney.
American journal of physiology. Renal physiology. 304(7):F972-81 [DOI] 10.1152/ajprenal.00550.2012. [PMID] 23324176.
2013
Expression of the rhesus glycoproteins, ammonia transporter family members, RHCG and RHBG in male reproductive organs.
Reproduction (Cambridge, England). 146(3):283-96 [DOI] 10.1530/REP-13-0154. [PMID] 23904565.
2013
Intercalated cell-specific Rh B glycoprotein deletion diminishes renal ammonia excretion response to hypokalemia.
American journal of physiology. Renal physiology. 304(4):F422-31 [DOI] 10.1152/ajprenal.00301.2012. [PMID] 23220726.
2013
Renal ammonia excretion in response to hypokalemia: effect of collecting duct-specific Rh C glycoprotein deletion.
American journal of physiology. Renal physiology. 304(4):F410-21 [DOI] 10.1152/ajprenal.00300.2012. [PMID] 23195675.
2013
Renal ammonia metabolism and transport.
Comprehensive Physiology. 3(1):201-20 [DOI] 10.1002/cphy.c120010. [PMID] 23720285.
2012
Proposed Mechanism in the Change of Cellular Composition in the Outer Medullary Collecting Duct During Potassium Homeostasis
Histology and Histopathology. 27:1559-1577
2012
Secondary Capillary Leak Syndrome Related To Pemetrexed Exposure
American journal of kidney diseases : the official journal of the National Kidney Foundation. 59(4):582-583 [DOI] 10.1053/j.ajkd.2011.12.031. [PMID] 22444494.
2011
Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin.
American journal of physiology. Renal physiology. 301(6):F1314-25 [DOI] 10.1152/ajprenal.00114.2011. [PMID] 21921024.
2011
Effect of hypokalemia on renal expression of the ammonia transporter family members, Rh B Glycoprotein and Rh C Glycoprotein, in the rat kidney.
American journal of physiology. Renal physiology. 301(4):F823-32 [DOI] 10.1152/ajprenal.00266.2011. [PMID] 21753075.
2011
Renal ischemia-reperfusion injury causes intercalated cell-specific disruption of occludin in the collecting duct.
Histochemistry and cell biology. 136(6):637-47 [DOI] 10.1007/s00418-011-0881-4. [PMID] 22048282.
2011
Role of NH3 and NH4+ transporters in renal acid-base transport.
American journal of physiology. Renal physiology. 300(1):F11-23 [DOI] 10.1152/ajprenal.00554.2010. [PMID] 21048022.
2010
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.
American journal of physiology. Renal physiology. 299(2):F369-79 [DOI] 10.1152/ajprenal.00120.2010. [PMID] 20462967.
2010
Expression of ammonia transporter family members, Rh B glycoprotein and Rh C glycoprotein, in the developing rat kidney.
American journal of physiology. Renal physiology. 299(1):F187-98 [DOI] 10.1152/ajprenal.00607.2009. [PMID] 20392801.
2010
Molecular physiology of the Rh ammonia transport proteins.
Current opinion in nephrology and hypertension. 19(5):471-7 [DOI] 10.1097/MNH.0b013e32833bfa4e. [PMID] 20539225.
2010
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.
American journal of physiology. Renal physiology. 299(5):F1065-77 [DOI] 10.1152/ajprenal.00277.2010. [PMID] 20719974.
2009
Basolateral expression of the ammonia transporter family member Rh C glycoprotein in the mouse kidney.
American journal of physiology. Renal physiology. 296(3):F543-55 [DOI] 10.1152/ajprenal.90637.2008. [PMID] 19129254.
2009
Collecting duct-specific Rh C glycoprotein deletion alters basal and acidosis-stimulated renal ammonia excretion.
American journal of physiology. Renal physiology. 296(6):F1364-75 [DOI] 10.1152/ajprenal.90667.2008. [PMID] 19321595.
2009
Expression of rh glycoproteins in the Mammalian kidney.
Electrolyte & blood pressure : E & BP. 7(1):14-9 [DOI] 10.5049/EBP.2009.7.1.14. [PMID] 21468180.
2009
Expression of the gas-transporting proteins, Rh B glycoprotein and Rh C glycoprotein, in the murine lung.
American journal of physiology. Lung cellular and molecular physiology. 297(1):L153-63 [DOI] 10.1152/ajplung.90524.2008. [PMID] 19429772.
2008
Expression of ammonia transporters, Rhbg and Rhcg, in chronic cyclosporine nephropathy in rats.
Nephron. Experimental nephrology. 110(2):e49-58 [DOI] 10.1159/000153245. [PMID] 18776723.
2008
Impaired acid secretion in cortical collecting duct intercalated cells from H-K-ATPase-deficient mice: role of HKalpha isoforms.
American journal of physiology. Renal physiology. 294(3):F621-7 [PMID] 18057185.
2007
A “weight-listing” paradox for candidates of renal transplantation?
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 7(3):550-9 [PMID] 17173655.
2007
Cellular distribution of the potassium channel KCNQ1 in normal mouse kidney.
American journal of physiology. Renal physiology. 292(1):F456-66 [PMID] 16896189.
2007
Effect of reduced renal mass on renal ammonia transporter family, Rh C glycoprotein and Rh B glycoprotein, expression.
American journal of physiology. Renal physiology. 293(4):F1238-47 [PMID] 17652373.
2007
Effects of ischemia-reperfusion injury on renal ammonia metabolism and the collecting duct.
American journal of physiology. Renal physiology. 293(4):F1342-54 [PMID] 17686949.
2007
Molecular mechanisms of renal ammonia transport.
Annual review of physiology. 69:317-40 [PMID] 17002591.
2007
Primary hyperaldosteronism in a patient with end-stage renal disease.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association – European Renal Association. 22(3):917-9 [PMID] 17127694.
2006
Changes in subcellular distribution of the ammonia transporter, Rhcg, in response to chronic metabolic acidosis.
American journal of physiology. Renal physiology. 290(6):F1443-52 [PMID] 16434569.
2006
Characterization of ammonia transport by the kidney Rh glycoproteins RhBG and RhCG.
American journal of physiology. Renal physiology. 290(2):F297-305 [PMID] 16131648.
2006
Expression of the ammonia transporter, rh C glycoprotein, in normal and neoplastic human kidney.
Journal of the American Society of Nephrology : JASN. 17(10):2670-9 [PMID] 16928804.
2006
Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.
American journal of physiology. Renal physiology. 290(2):F397-408 [PMID] 16144966.
2006
Rhabdomyolysis and acute renal failure in a patient treated with daptomycin.
The Journal of antimicrobial chemotherapy. 57(3):578-9 [PMID] 16410267.
2005
Apical ammonia transport by the mouse inner medullary collecting duct cell (mIMCD-3).
American journal of physiology. Renal physiology. 289(2):F347-58 [PMID] 15798090.
2005
Expression of the ammonia transporter proteins Rh B glycoprotein and Rh C glycoprotein in the intestinal tract.
American journal of physiology. Gastrointestinal and liver physiology. 288(5):G1036-47 [PMID] 15576624.
2005
Intercalated cell H+/OH- transporter expression is reduced in Slc26a4 null mice.
American journal of physiology. Renal physiology. 289(6):F1262-72 [PMID] 16144965.
2004
Basolateral ammonium transport by the mouse inner medullary collecting duct cell (mIMCD-3).
American journal of physiology. Renal physiology. 287(4):F628-38 [PMID] 15149971.
2004
The Rh gene family and renal ammonium transport.
Current opinion in nephrology and hypertension. 13(5):533-40 [PMID] 15300160.
2003
Localization of the ammonium transporter proteins RhBG and RhCG in mouse kidney.
American journal of physiology. Renal physiology. 284(2):F323-37 [PMID] 12388412.
2003
Localization of the ammonium transporters, Rh B glycoprotein and Rh C glycoprotein, in the mouse liver.
Gastroenterology. 124(5):1432-40 [PMID] 12730882.
2003
Renal microperfusion techniques.
Methods in molecular medicine. 86:457-73 [PMID] 12886788.
2002
Expression and developmental regulation of the NMDA receptor subunits in the kidney and cardiovascular system.
American journal of physiology. Regulatory, integrative and comparative physiology. 283(4):R964-71 [PMID] 12228067.
2002
Mechanisms through which ammonia regulates cortical collecting duct net proton secretion.
American journal of physiology. Renal physiology. 282(6):F1120-8 [PMID] 11997329.
2001
Effects of ammonia on acid-base transport by the B-type intercalated cell.
Journal of the American Society of Nephrology : JASN. 12(8):1607-1614 [DOI] 10.1681/ASN.V1281607. [PMID] 11461932.
1999
Apical proton secretion by the inner stripe of the outer medullary collecting duct.
The American journal of physiology. 276(4):F606-13 [DOI] 10.1152/ajprenal.1999.276.4.F606. [PMID] 10198421.
1999
H-K-ATPase in the RCCT-28A rabbit cortical collecting duct cell line.
The American journal of physiology. 276(2):F237-45 [DOI] 10.1152/ajprenal.1999.276.2.F237. [PMID] 9950954.
1998
Hyperkalemia: a potential silent killer.
Journal of the American Society of Nephrology : JASN. 9(8):1535-43 [PMID] 9697678.
1998
Regulation of B-type intercalated cell apical anion exchange activity by CO2/HCO3-.
The American journal of physiology. 274(6):F1086-94 [DOI] 10.1152/ajprenal.1998.274.6.F1086. [PMID] 9841500.
1997
Hypokalemia–consequences, causes, and correction.
Journal of the American Society of Nephrology : JASN. 8(7):1179-88 [PMID] 9219169.
1997
Intracellular pH regulation in the rabbit cortical collecting duct A-type intercalated cell.
The American journal of physiology. 273(3 Pt 2):F340-7 [PMID] 9321906.
1996
H(+)-K(+)-ATPase in rabbit cortical collecting duct B-type intercalated cell.
The American journal of physiology. 270(3 Pt 2):F518-30 [PMID] 8780256.
1995
Regulation of luminal alkalinization and acidification in the cortical collecting duct by angiotensin II.
The American journal of physiology. 269(5 Pt 2):F730-8 [PMID] 7503240.
1994
Distribution of Cl-/HCO3- exchange and intercalated cells in rabbit cortical collecting duct.
The American journal of physiology. 267(6 Pt 2):F952-64 [PMID] 7810703.
1994
Mechanisms of bicarbonate transport by cultured rabbit inner medullary collecting duct cells.
The American journal of physiology. 266(3 Pt 2):F466-76 [PMID] 8160796.
1993
Regulation of intracellular pH in two cell populations of inner stripe of rabbit outer medullary collecting duct.
The American journal of physiology. 265(3 Pt 2):F406-15 [PMID] 8214100.

Grants

Sep 2021 ACTIVE
Molecular Mechanisms Regulating Ammonia Metabolism
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2017 – May 2021
Mechanisms of Malnutrition in Cirrhosis with Portosystemic Shunting
Role: Principal Investigator
Funding: CLEVELAND CLINIC LERNER COLL OF MED via NATL INST OF HLTH NIGMS
Dec 2015 – Sep 2021
Molecular mechanisms regulating ammonia metabolism
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK
Jun 2014 – Mar 2019
H/HCO3 Transport in the Collecting Duct
Role: Principal Investigator
Funding: NATL INST OF HLTH NIDDK

Education

Fellowship – Nephrology
1987-1990 · Washington University, St. Louis (Barnes-Jewish Hospital)
Residency – Internal Medicine
1985-1987 · University of Texas Health Science Center at San Antonio
Internship – Internal Medicine
1984-1985 · University of Texas Health Science Center at San Antonio
Medical Degree
1984 · Vanderbilt University

Contact Details

Phones:
Business:
(352) 273-5358
Emails:
Addresses:
Business Mailing:
PO Box 100224
GAINESVILLE FL 32610
Business Street:
1600 SW ARCHER RD RM CG 98
GAINESVILLE FL 32610