Colin Sumners,
Professor Emeritus
Department:
Department of Physiology and Aging
Business Phone:
(352) 392-4485
Business Email:
csumners@ufl.edu
Teaching Profile
Courses Taught
2016
IDS4930 Special Topics in Interdisciplinary Studies
2016
MDT7002 Elect Top/Physiology
2016
GMS7003 Respon Conduct Biomed
2013-2015
BMS4905 Medical Sciences Senior Research
2014
PHA7979 Advanced Research
2014
PHA7980 Research for Doctoral Dissertation
2012
BSC3096 Human Physiology
2011-2012
DEN5120C Physiology
2010
IDH4917 Undergrad Research
2007-2009
GMS6405 Fundamentals of Endocrine Physiology
2006
GMS6181 Spec Topics Microbiol
Research Profile
Open Researcher and Contributor ID (ORCID)
0000-0002-9689-2255
Publications
2024
Development of an automated, high-throughput assay to detect angiotensin AT2-receptor agonistic compounds by nitric oxide measurements in vitro.
Peptides.
172
[DOI] 10.1016/j.peptides.2023.171137.
[PMID] 38142816.
2023
Editorial: The neuroendocrine, autonomic and neuroinflammatory stress axes in cardiometabolic disease.
Frontiers in physiology.
14
[DOI] 10.3389/fphys.2023.1293219.
[PMID] 37817982.
2023
Functional assay for assessment of agonistic or antagonistic activity of angiotensin AT2 receptor ligands reveals that EMA401 and PD123319 have agonistic properties.
Biochemical pharmacology.
216
[DOI] 10.1016/j.bcp.2023.115793.
[PMID] 37689272.
2023
Sodium Intake and Disease: Another Relationship to Consider
Nutrients.
15(3)
[DOI] 10.3390/nu15030535.
[PMID] 36771242.
2022
Angiotensin Receptors – Affinity and Beyond
Clinical Science.
136(10):799-802
[DOI] 10.1042/cs20220024.
2022
Quantitative Phosphoproteomics of the Angiotensin AT2-Receptor Signaling Network Identifies HDAC1 (Histone-Deacetylase-1) and p53 as Mediators of Antiproliferation and Apoptosis.
Hypertension (Dallas, Tex. : 1979).
79(11):101161HYPERTENSIONAHA12118620-2541
[DOI] 10.1161/HYPERTENSIONAHA.121.18620.
2022
Targeting angiotensin type-2 receptors located on pressor neurons in the nucleus of the solitary tract to relieve hypertension in mice
Cardiovascular Research.
118(3):883-896
[DOI] 10.1093/cvr/cvab085.
[PMID] 33723600.
2022
The Angiotensin AT2Receptor: From a Binding Site to a Novel Therapeutic Target
Pharmacological Reviews.
74(4):1051-1135
[DOI] 10.1124/pharmrev.120.000281.
[PMID] 36180112.
2020
Angiotensin Type 2 Receptors: Painful, or Not?
Frontiers in pharmacology.
11
[DOI] 10.3389/fphar.2020.571994.
[PMID] 33424587.
2020
Brain Angiotensin Type-1 and Type-2 Receptors in Physiological and Hypertensive Conditions: Focus on Neuroinflammation
Current Hypertension Reports.
22(7)
[DOI] 10.1007/s11906-020-01062-0.
[PMID] 32661792.
2020
Brain angiotensin type-1 and type-2 receptors: cellular locations under normal and hypertensive conditions.
Hypertension research : official journal of the Japanese Society of Hypertension.
43(4):281-295
[DOI] 10.1038/s41440-019-0374-8.
[PMID] 31853042.
2020
Correcting the imbalanced protective RAS in COVID-19 with angiotensin AT2-receptor agonists
Clinical Science.
134(22):2987-3006
[DOI] 10.1042/cs20200922.
2020
The Renin-Angiotensin System in Hypertension, a Constantly Renewing Classic: Focus on the Angiotensin AT2-Receptor.
The Canadian journal of cardiology.
36(5):683-693
[DOI] 10.1016/j.cjca.2020.02.095.
[PMID] 32389341.
2019
Angiotensin receptor expression revealed by reporter mice and beneficial effects of AT2R agonist in retinal cells.
Experimental eye research.
187
[DOI] 10.1016/j.exer.2019.107770.
[PMID] 31449794.
2019
Anti-fibrotic mechanisms of angiotensin AT2 -receptor stimulation.
Acta physiologica (Oxford, England).
227(1)
[DOI] 10.1111/apha.13280.
[PMID] 30957953.
2019
Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension.
Circulation research.
125(1):104-116
[DOI] 10.1161/CIRCRESAHA.119.313965.
[PMID] 31219753.
2019
Importance of AT1 and AT2 receptors in the nucleus of the solitary tract in cardiovascular responses induced by a high-fat diet.
Hypertension research : official journal of the Japanese Society of Hypertension.
42(4):439-449
[DOI] 10.1038/s41440-018-0196-0.
[PMID] 30631157.
2019
Microglial Cells Impact Gut Microbiota and Gut Pathology in Angiotensin II-Induced Hypertension.
Circulation research.
124(5):727-736
[DOI] 10.1161/CIRCRESAHA.118.313882.
[PMID] 30612527.
2018
ACE2 activator diminazene aceturate reduces adiposity but preserves lean mass in young and old rats.
Experimental gerontology.
111:133-140
[DOI] 10.1016/j.exger.2018.07.008.
[PMID] 30006298.
2018
Angiotensin 1-7 Overexpression Mediated by a Capsid-optimized AAV8 Vector Leads to Significant Growth Inhibition of Hepatocellular Carcinoma In vivo.
International journal of biological sciences.
14(1):57-68
[DOI] 10.7150/ijbs.22235.
[PMID] 29483825.
2018
Butyrate regulates inflammatory cytokine expression without affecting oxidative respiration in primary astrocytes from spontaneously hypertensive rats.
Physiological reports.
6(14)
[DOI] 10.14814/phy2.13732.
[PMID] 30039527.
2018
Identification of protein phosphatase involvement in the AT2 receptor-induced activation of endothelial nitric oxide synthase.
Clinical science (London, England : 1979).
132(7):777-790
[DOI] 10.1042/CS20171598.
[PMID] 29540539.
2018
Neuroprotection by post-stroke administration of an oral formulation of angiotensin-(1-7) in ischaemic stroke.
Experimental physiology.
103(6):916-923
[DOI] 10.1113/EP086957.
[PMID] 29663576.
2018
Neuroprotection via AT2 receptor agonists in ischemic stroke.
Clinical science (London, England : 1979).
132(10):1055-1067
[DOI] 10.1042/CS20171549.
[PMID] 29802210.
2018
Protective effects of the angiotensin II AT2 receptor agonist compound 21 in ischemic stroke: a nose-to-brain delivery approach.
Clinical science (London, England : 1979).
132(5):581-593
[DOI] 10.1042/CS20180100.
[PMID] 29500223.
2018
Small-molecule AT2 receptor agonists.
Medicinal research reviews.
38(2):602-624
[DOI] 10.1002/med.21449.
[PMID] 28609561.
2018
The Selective Angiotensin II Type 2 Receptor Agonist, Compound 21, Attenuates the Progression of Lung Fibrosis and Pulmonary Hypertension in an Experimental Model of Bleomycin-Induced Lung Injury.
Frontiers in physiology.
9
[DOI] 10.3389/fphys.2018.00180.
[PMID] 29636695.
2017
A Unique “Angiotensin-Sensitive” Neuronal Population Coordinates Neuroendocrine, Cardiovascular, and Behavioral Responses to Stress
The Journal of Neuroscience.
37(13):3478-3490
[DOI] 10.1523/jneurosci.3674-16.2017.
2017
AAV-Mediated angiotensin 1-7 overexpression inhibits tumor growth of lung cancer in vitro and in vivo.
Oncotarget.
8(1):354-363
[DOI] 10.18632/oncotarget.13396.
[PMID] 27861149.
2017
Angiotensin II type 2 receptor promotes apoptosis and inhibits angiogenesis in bladder cancer.
Journal of experimental & clinical cancer research : CR.
36(1)
[DOI] 10.1186/s13046-017-0542-0.
[PMID] 28599664.
2017
Centrally Mediated Cardiovascular Actions of the Angiotensin II Type 2 Receptor.
Trends in endocrinology and metabolism: TEM.
28(9):684-693
[DOI] 10.1016/j.tem.2017.06.002.
[PMID] 28733135.
2017
Increased Expression of Macrophage Migration Inhibitory Factor in the Nucleus of the Solitary Tract Attenuates Renovascular Hypertension in Rats.
American journal of hypertension.
30(4):435-443
[DOI] 10.1093/ajh/hpx001.
[PMID] 28158469.
2017
Post-stroke angiotensin II type 2 receptor activation provides long-term neuroprotection in aged rats.
PloS one.
12(7)
[DOI] 10.1371/journal.pone.0180738.
[PMID] 28671997.
2017
Protective Angiotensin Type 2 Receptors in the Brain and Hypertension.
Current hypertension reports.
19(6)
[DOI] 10.1007/s11906-017-0746-x.
[PMID] 28488048.
2017
Role of environmental stressors in determining the developmental outcome of neonatal anesthesia.
Psychoneuroendocrinology.
81:96-104
[DOI] 10.1016/j.psyneuen.2017.04.001.
[PMID] 28433802.
2016
Adenovirus-Mediated Angiotensin II Type 2 Receptor Overexpression Inhibits Tumor Growth of Prostate Cancer In Vivo.
Journal of Cancer.
7(2):184-91
[DOI] 10.7150/jca.12841.
[PMID] 26819642.
2016
Angiotensin Type-2 Receptors Influence the Activity of Vasopressin Neurons in the Paraventricular Nucleus of the Hypothalamus in Male Mice.
Endocrinology.
157(8):3167-80
[DOI] 10.1210/en.2016-1131.
[PMID] 27267713.
2016
Angiotensin-(1-7) Decreases Cell Growth and Angiogenesis of Human Nasopharyngeal Carcinoma Xenografts.
Molecular cancer therapeutics.
15(1):37-47
[DOI] 10.1158/1535-7163.MCT-14-0981.
[PMID] 26671566.
2016
Direct anti-inflammatory effects of angiotensin-(1-7) on microglia.
Journal of neurochemistry.
136(1):163-71
[DOI] 10.1111/jnc.13386.
[PMID] 26448556.
2016
Modulating of ocular inflammation with macrophage migration inhibitory factor is associated with notch signalling in experimental autoimmune uveitis.
Clinical and experimental immunology.
183(2):280-93
[DOI] 10.1111/cei.12710.
[PMID] 26400205.
2016
Overexpression of AT2R in the solitary-vagal complex improves baroreflex in the spontaneously hypertensive rat.
Neuropeptides.
60:29-36
[DOI] 10.1016/j.npep.2016.06.006.
[PMID] 27469059.
2016
Reporter mouse strain provides a novel look at angiotensin type-2 receptor distribution in the central nervous system.
Brain structure & function.
221(2):891-912
[DOI] 10.1007/s00429-014-0943-1.
[PMID] 25427952.
2016
Serum activity of angiotensin converting enzyme 2 is decreased in patients with acute ischemic stroke.
Journal of the renin-angiotensin-aldosterone system : JRAAS.
17(3)
[DOI] 10.1177/1470320316661060.
[PMID] 27488276.
2015
Activation of the Neuroprotective Angiotensin-Converting Enzyme 2 in Rat Ischemic Stroke.
Hypertension (Dallas, Tex. : 1979).
66(1):141-8
[DOI] 10.1161/HYPERTENSIONAHA.115.05185.
[PMID] 25941346.
2015
Anesthesia with sevoflurane in neonatal rats: Developmental neuroendocrine abnormalities and alleviating effects of the corticosteroid and Cl(-) importer antagonists.
Psychoneuroendocrinology.
60:173-81
[DOI] 10.1016/j.psyneuen.2015.06.016.
[PMID] 26150359.
2015
Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison.
Clinical science (London, England : 1979).
128(4):227-34
[DOI] 10.1042/CS20130515.
[PMID] 25328009.
2015
Angiotensin type 2 receptors: blood pressure regulation and end organ damage.
Current opinion in pharmacology.
21:115-21
[DOI] 10.1016/j.coph.2015.01.004.
[PMID] 25677800.
2015
Direct angiotensin type 2 receptor (AT2R) stimulation attenuates T-cell and microglia activation and prevents demyelination in experimental autoimmune encephalomyelitis in mice.
Clinical science (London, England : 1979).
128(2):95-109
[DOI] 10.1042/CS20130601.
[PMID] 25052203.
2015
Lentiviral Vectors Mediate Long-Term and High Efficiency Transgene Expression in HEK 293T cells.
International journal of medical sciences.
12(5):407-15
[DOI] 10.7150/ijms.11270.
[PMID] 26005375.
2015
Neuroprotective mechanisms of the ACE2-angiotensin-(1-7)-Mas axis in stroke.
Current hypertension reports.
17(2)
[DOI] 10.1007/s11906-014-0512-2.
[PMID] 25620630.
2015
Novel mechanism within the paraventricular nucleus reduces both blood pressure and hypothalamic pituitary-adrenal axis responses to acute stress.
American journal of physiology. Heart and circulatory physiology.
309(4):H634-45
[DOI] 10.1152/ajpheart.00207.2015.
[PMID] 26071542.
2015
Role of neurons and glia in the CNS actions of the renin-angiotensin system in cardiovascular control.
American journal of physiology. Regulatory, integrative and comparative physiology.
309(5):R444-58
[DOI] 10.1152/ajpregu.00078.2015.
[PMID] 26084692.
2015
Selective activation of angiotensin AT2 receptors attenuates progression of pulmonary hypertension and inhibits cardiopulmonary fibrosis.
British journal of pharmacology.
172(9):2219-31
[DOI] 10.1111/bph.13044.
[PMID] 25522140.
2014
Arterial Pressure and Gene Expression in the Nucleus of the Solitary Tract in Rats Fed With High-Fat Diet
The FASEB's Journal.
28(1, S)
2014
Cardiovascular Effects of Chronically Increasing Angiotensin II Type 2 Receptor Expression in the Nucleus of the Solitary Tract
The FASEB's Journal.
28(1, S)
2014
Centrally administered angiotensin-(1-7) increases the survival of stroke-prone spontaneously hypertensive rats.
Experimental physiology.
99(2):442-53
[DOI] 10.1113/expphysiol.2013.075242.
[PMID] 24142453.
2014
Cerebroprotective action of angiotensin peptides in stroke.
Clinical science (London, England : 1979).
126(3):195-205
[DOI] 10.1042/CS20130324.
[PMID] 24102099.
2014
Direct pro-inflammatory effects of prorenin on microglia.
PloS one.
9(10)
[DOI] 10.1371/journal.pone.0092937.
[PMID] 25302502.
2014
Endocrine and neurobehavioral abnormalities induced by propofol administered to neonatal rats.
Anesthesiology.
121(5):1010-7
[DOI] 10.1097/ALN.0000000000000366.
[PMID] 24992523.
2014
Gene expression profiling associated with angiotensin II type 2 receptor-induced apoptosis in human prostate cancer cells.
PloS one.
9(3)
[DOI] 10.1371/journal.pone.0092253.
[PMID] 24658029.
2014
Increased expression of angiotensin II type 2 receptors in the solitary-vagal complex blunts renovascular hypertension.
Hypertension (Dallas, Tex. : 1979).
64(4):777-83
[DOI] 10.1161/HYPERTENSIONAHA.114.03188.
[PMID] 24958505.
2014
Obesity induces neuroinflammation mediated by altered expression of the renin-angiotensin system in mouse forebrain nuclei.
Physiology & behavior.
136:31-8
[DOI] 10.1016/j.physbeh.2014.01.016.
[PMID] 24508821.
2014
The angiotensin type 2 receptor agonist Compound 21 elicits cerebroprotection in endothelin-1 induced ischemic stroke.
Neuropharmacology.
81:134-41
[DOI] 10.1016/j.neuropharm.2014.01.044.
[PMID] 24508710.
2013
Adenoviral and adeno-associated viral vectors-mediated neuronal gene transfer to cardiovascular control regions of the rat brain.
International journal of medical sciences.
10(5):607-16
[DOI] 10.7150/ijms.5700.
[PMID] 23569423.
2013
Angiotensin type 1a receptors in the paraventricular nucleus of the hypothalamus protect against diet-induced obesity.
The Journal of neuroscience : the official journal of the Society for Neuroscience.
33(11):4825-33
[DOI] 10.1523/JNEUROSCI.3806-12.2013.
[PMID] 23486953.
2013
Anti-Inflammatory Action of Angiotensin-(1-7) and the Angiotensin Type 2 Receptor Agonist Compound 21 in Hypothalamic Microglia
The FASEB's Journal.
27
2013
Anti-inflammatory effects of angiotensin-(1-7) in ischemic stroke.
Neuropharmacology.
71:154-63
[DOI] 10.1016/j.neuropharm.2013.03.025.
[PMID] 23583926.
2013
Chronic knockdown of the nucleus of the solitary tract AT1 receptors increases blood inflammatory-endothelial progenitor cell ratio and exacerbates hypertension in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979).
61(6):1328-33
[DOI] 10.1161/HYPERTENSIONAHA.111.00156.
[PMID] 23547238.
2013
Comment on “protective arms of the renin-angiotensin system in neurological disease”: Reply.
Clinical and experimental pharmacology & physiology.
40(11):838-9
[DOI] 10.1111/1440-1681.12168.
[PMID] 24033585.
2013
Effects of angiotensin II type 2 receptor overexpression on the growth of hepatocellular carcinoma cells in vitro and in vivo.
PloS one.
8(12)
[DOI] 10.1371/journal.pone.0083754.
[PMID] 24391821.
2013
In Vitro Aav5-Mediated Expression of Metalloendopeptidase Neurolysin in Mouse Brain Primary Cultures
The FASEB's Journal.
27
2013
Increased Expression of At2 Receptors in the Nucleus of the Solitary Tract Improves Baroreflex Function in Renovascular Hypertensive Rats.
The FASEB's Journal.
27
2013
Interleukin-10 inhibits angiotensin II-induced decrease in neuronal potassium current.
American journal of physiology. Cell physiology.
304(8):C801-7
[DOI] 10.1152/ajpcell.00398.2012.
[PMID] 23426971.
2013
Macrophage Migration Inhibitory Factor (Mif) Acts in the Paraventricular Nucleus of the Hypothalamus (Pvn) To Decrease the Corticosterone Response To Stress
The FASEB's Journal.
27
2013
Macrophage Migration Inhibitory Factor (Mif) Decreases Neuroinflammation in the Solitary Tract Nucleus (Nts) of Spontaneously Hypertensive Rats (Shr).
The FASEB's Journal.
27
2013
Macrophage Migration Inhibitory Factor (Mif) Decreases Neuroinflammation in the Solitary Tract Nucleus (Nts) of Spontaneously Hypertensive Rats (Shr).
The FASEB's Journal.
27
2013
Macrophage migration inhibitory factor in the nucleus of solitary tract decreases blood pressure in SHRs.
Cardiovascular research.
97(1):153-60
[DOI] 10.1093/cvr/cvs297.
[PMID] 22997157.
2013
Mas Mediated Cerebroprotective Action of the Angiotensin Type 2 Receptor Agonist Compound 21 in Ischemic Stroke.
The FASEB's Journal.
27
2013
Neuroimmune communication in hypertension and obesity: a new therapeutic angle?
Pharmacology & therapeutics.
138(3):428-40
[DOI] 10.1016/j.pharmthera.2013.02.005.
[PMID] 23458610.
2013
Nucleus of the solitary tract (pro)renin receptor-mediated antihypertensive effect involves nuclear factor-κB-cytokine signaling in the spontaneously hypertensive rat.
Hypertension (Dallas, Tex. : 1979).
61(3):622-7
[DOI] 10.1161/HYPERTENSIONAHA.111.199836.
[PMID] 23319541.
2013
Protective arms of the renin-angiotensin-system in neurological disease.
Clinical and experimental pharmacology & physiology.
40(8):580-8
[DOI] 10.1111/1440-1681.12137.
[PMID] 23735163.
2013
Respiratory Responses To Over-Pressurization Blast Injury Rats Exposed To Hypercapnia
The FASEB's Journal.
27
2013
Role of Microglia Activation in Neurogenic Hypertension
Glia.
61
2012
Angiotensin II type 2 receptor-stimulated activation of plasma prekallikrein and bradykinin release: role of SHP-1.
American journal of physiology. Heart and circulatory physiology.
302(12):H2553-9
[DOI] 10.1152/ajpheart.01157.2011.
[PMID] 22523247.
2012
Angiotensin Type 2 Receptors (At2R) Over Expression in the Nucleus of the Solitary Tract (Nts) Attenuate Renovascular Hypertension
The FASEB's Journal.
26
2012
Angiotensin Type 2 Receptors Inhibit Growth of Hepatocellular Carcinoma Through Cell Cycle Arrest and Apoptosis
Molecular Therapy.
20
2012
Effects of Angiotensin Type 2 Receptor Overexpression On Gene Expression Profiles in Human Prostate Cancer Cells
Molecular Therapy.
20:S186-S187
2012
Macrophage Inhibitory Factor (Mif) in the Nucleus of Tract Solitary (Nts) Improves Baroreflex Function in Spontaneously Hypertensive Rats (Shr)
The FASEB's Journal.
26
2012
Microglial-Neuronal Interactions in the Paraventricular Nucleus (Pvn): a Potential Mechanism Underlying Neurogenic Hypertension
The FASEB's Journal.
26
2012
Moderate cardiac-selective overexpression of angiotensin II type 2 receptor protects cardiac functions from ischaemic injury.
Experimental physiology.
97(1):89-101
[DOI] 10.1113/expphysiol.2011.060673.
[PMID] 21967903.
2012
Pro-Inflammatory Action of Renin-Angiotensin-Aldosterone System (Raas) in Hypothalamic Astrocytes From Spontaneously Hypertensive Rats (Shr)
The FASEB's Journal.
26
2012
Repeated Restraint Stress Increases Baseline Blood Pressure in Spontaneously Hypertensive Rats
The FASEB's Journal.
26
2012
The Role of Macrophage Migration Inhibitory Factor (Mif) in the Paraventricular Nucleus (Pvn) During Acute Stress
The FASEB's Journal.
26
2012
The Role of Macrophage Migration Inhibitory Factor (Mif) in the Paraventricular Nucleus (Pvn) During Acute Stress
The FASEB's Journal.
26
2011
Cerebroprotection by angiotensin-(1-7) in endothelin-1-induced ischaemic stroke.
Experimental physiology.
96(10):1084-96
[DOI] 10.1113/expphysiol.2011.058578.
[PMID] 21685445.
2011
Halogenated aromatic amino acid 3,5-dibromo-D: -tyrosine produces beneficial effects in experimental stroke and seizures.
Amino acids.
40(4):1151-8
[DOI] 10.1007/s00726-010-0739-4.
[PMID] 20839013.
2011
Lentivirus-mediated overexpression of angiotensin-(1-7) attenuated ischaemia-induced cardiac pathophysiology.
Experimental physiology.
96(9):863-74
[DOI] 10.1113/expphysiol.2011.056994.
[PMID] 21685447.
2011
Role of Shp-1 in Angiotensin Ii Type 2 Receptor-Stimulated Activation of Plasma Kallikrein and Bradykinin Release
Hypertension.
58
2011
Stimulatory Action of the Renin-Angiotensin-Aldosterone System On the Production of Microglial Derived Cytokines
Hypertension.
58
2010
A current view of brain renin-angiotensin system: Is the (pro)renin receptor the missing link?
Pharmacology & therapeutics.
125(1):27-38
[DOI] 10.1016/j.pharmthera.2009.07.007.
[PMID] 19723538.
2010
Angiotensin II Type 2 Receptor Mediates Bradykinin Release Via Prolylcarboxypeptidase-Dependent Pathway in Endothelial Cells
Hypertension.
56
2010
Brain cytokines as neuromodulators in cardiovascular control.
Clinical and experimental pharmacology & physiology.
37(2):e52-7
[DOI] 10.1111/j.1440-1681.2009.05234.x.
[PMID] 19566837.
2010
Brain microglial cytokines in neurogenic hypertension.
Hypertension (Dallas, Tex. : 1979).
56(2):297-303
[DOI] 10.1161/HYPERTENSIONAHA.110.150409.
[PMID] 20547972.
2010
Elevated Expression of Macrophage Migration Inhibitory Factor Within Nucleus of Solitary Tract Neurons Decreases Blood Pressure in Spontaneously Hypertensive Rats
Hypertension.
56
2010
Hyperosmolality Induced Changes in Gene Expression in Cardiovascular Control Centers in the Brain
Hypertension.
56
2010
Interleukin-10 Decreases Angiotensin II Induced Neuronal Excitation
Hypertension.
56
2010
Involvement of the Brain (Pro) Renin Receptor in Cardiovascular Homeostasis
Hypertension.
56
2010
Involvement of the brain (pro)renin receptor in cardiovascular homeostasis.
Circulation research.
107(7):934-8
[DOI] 10.1161/CIRCRESAHA.110.226977.
[PMID] 20689062.
2010
Macrophage migration inhibitory factor in the paraventricular nucleus plays a major role in the sympathoexcitatory response to salt.
Hypertension (Dallas, Tex. : 1979).
56(5):956-63
[DOI] 10.1161/HYPERTENSIONAHA.110.155101.
[PMID] 20937969.
2010
Role of prolylcarboxypeptidase in angiotensin II type 2 receptor-mediated bradykinin release in mouse coronary artery endothelial cells.
Hypertension (Dallas, Tex. : 1979).
56(3):384-90
[DOI] 10.1161/HYPERTENSIONAHA.110.155051.
[PMID] 20606103.
2010
Selective tropism of the recombinant adeno-associated virus 9 serotype for rat cardiac tissue.
The journal of gene medicine.
12(1):22-34
[DOI] 10.1002/jgm.1404.
[PMID] 19830780.
2010
Therapeutic implications of the vasoprotective axis of the renin-angiotensin system in cardiovascular diseases.
Hypertension (Dallas, Tex. : 1979).
55(2):207-13
[DOI] 10.1161/HYPERTENSIONAHA.109.140145.
[PMID] 20038757.
2009
3,5-Dibromo-L-Phenylalanine Depresses Pentylenetetrazole-Induced Seizures and Reduces Neurological and Sensorimotor Gating Deficits Caused By Stroke
Journal of the Neurological Sciences.
285
2009
Aav-Mediated Increases in (Pro)Renin Receptor Expression in the Supraoptic Nucleus Regulate Vasopressin Secretion and Body Fluid Homeostasis
Hypertension.
54
2009
Angiotensin Type 2 Receptor Improves Cardiac Function and Attenuates Left Ventricular Remodeling Following Myocardial Infarction in the Rat
Hypertension.
54:E71-E72
2009
Angiotensin type 2 receptor-mediated apoptosis of human prostate cancer cells.
Molecular cancer therapeutics.
8(12):3255-65
[DOI] 10.1158/1535-7163.MCT-09-0237.
[PMID] 19996275.
2009
Candesartan pretreatment is cerebroprotective in a rat model of endothelin-1-induced middle cerebral artery occlusion.
Experimental physiology.
94(8):937-46
[DOI] 10.1113/expphysiol.2009.047936.
[PMID] 19429641.
2009
Central Angiotensin Type 2 Receptor: An Inhibitory Mediator of Sympathetic Drive in Heart Failure
Journal of Physiological Sciences.
59
2009
Efficacy of 3,5-dibromo-L-phenylalanine in rat models of stroke, seizures and sensorimotor gating deficit.
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2009
Increased Expression of Angiotensin Type 2 Receptors in the Rostral Ventrolateral Medulla Attenuates Renal Sympathetic Nerve Activity in Rats With Chronic Heart Failure
Hypertension.
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Increased Expression of Ndufa10, a Subunit of Mitochondrial Complex 1, in the Cardiovascular Relevant Brain Regions of the Spontaneously Hypertensive Rat
Hypertension.
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Interleukin-10 in the Hypothalamic Paraventricular Nucleus Attenuates the Pressor Response To Angiotensin II
Hypertension.
54
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Phosphate-activated glutaminase-containing neurons in the rat paraventricular nucleus express angiotensin type 1 receptors.
Hypertension (Dallas, Tex. : 1979).
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2009
Prorenin Receptor (Prr) Immunoreactivity (Ir) in Cardiovascular (Cv) Regulatory Brain Nuclei Is Exclusive To Neurons and Colocalized With the Angiotensin (Ang) II Type 1 Receptor (At1R)
Hypertension.
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2008
Angiotensin II increases GABAB receptor expression in nucleus tractus solitarii of rats.
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Characterization of the Rostral Vetrolateral Medulla (Rvlm) Neurons From Adult Rat Brain in Primary Culture
Journal of Hypertension.
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Effects of angiotensin type 2 receptor overexpression in the rostral ventrolateral medulla on blood pressure and urine excretion in normal rats.
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2008
Glutamatergic Neurons in Adult Rat Paraventricular Nucleus Contain Functional Angiotensin Type 1 Receptors
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Immunostaining evidence for PI(4,5)P2 localization at the leading edge of chemoattractant-stimulated HL-60 cells.
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Macrophage migration inhibitory factor in hypothalamic paraventricular nucleus neurons decreases blood pressure in spontaneously hypertensive rats.
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Perinatal loss of Nkx2-5 results in rapid conduction and contraction defects.
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Rvlm Neurons From the Adult Rat Brain Maintain in Vivo Physiological Properties in Primary Culture
Hypertension.
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Basal and angiotensin II-inhibited neuronal delayed-rectifier K+ current are regulated by thioredoxin.
American journal of physiology. Cell physiology.
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2007
Lack of macrophage migration inhibitory factor regulation is linked to the increased chronotropic action of angiotensin II in SHR neurons.
Hypertension (Dallas, Tex. : 1979).
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2007
Potentiation of the antihypertensive action of losartan by peripheral overexpression of the ANG II type 2 receptor.
American journal of physiology. Heart and circulatory physiology.
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2006
Halogenated derivatives of aromatic amino acids exhibit balanced antiglutamatergic actions: potential applications for the treatment of neurological and neuropsychiatric disorders.
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2006
Macrophage migration inhibitory factor in the PVN attenuates the central pressor and dipsogenic actions of angiotensin II.
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Macrophage migration inhibitory factor increases neuronal delayed rectifier K+ current.
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A pH-dependent increase in neuronal glutamate efflux in vitro: possible involvement of ASCT1.
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Adenoviral-mediated neuron specific transduction of angiotensin II type 2 receptors.
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Angiotensin II type 2 receptor-mediated gene expression profiling in human coronary artery endothelial cells.
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Differential modulation of glutamatergic transmission by 3,5-dibromo-L-phenylalanine.
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Impaired glutamatergic synaptic transmission in the PKU brain.
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Intronic enhancement of angiotensin II type 2 receptor transgene expression in vitro and in vivo.
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Long-term changes in glutamatergic synaptic transmission in phenylketonuria.
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NAD(P)H oxidase inhibition attenuates neuronal chronotropic actions of angiotensin II.
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Selective silencing of angiotensin receptor subtype 1a (AT1aR) by RNA interference.
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Angiotensin II type 2 receptor gene transfer elicits cardioprotective effects in an angiotensin II infusion rat model of hypertension.
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Central angiotensin II increases biosynthesis of tyrosine hydroxylase in the rat adrenal medulla.
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Elevated blood pressure in normotensive rats produced by ‘knockdown’ of the angiotensin type 2 receptor.
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Macrophage migration inhibitory factor: an intracellular inhibitor of angiotensin II-induced increases in neuronal activity.
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Prevention of cardiac hypertrophy by angiotensin II type-2 receptor gene transfer.
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Recombinant adeno-associated virus serotype 2 effectively transduces primary rat brain astrocytes and microglia.
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Angiotensin II induction of AP-1 in neurons requires stimulation of PI3-K and JNK.
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Cytokine-stimulated inducible nitric oxide synthase expression in astroglia: role of Erk mitogen-activated protein kinase and NF-kappaB.
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Desflurane and sevoflurane attenuate oxygen and glucose deprivation-induced neuronal cell death.
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Drinking behavior elicited by central injection of angiotensin II: roles for protein kinase C and Ca2+/calmodulin-dependent protein kinase II.
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L-phenylalanine selectively depresses currents at glutamatergic excitatory synapses.
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Modulation of delayed rectifier potassium current by angiotensin II in CATH.a cells.
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PI3-kinase inhibitors abolish the enhanced chronotropic effects of angiotensin II in spontaneously hypertensive rat brain neurons.
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Transduction of a functional domain of the AT1 receptor in neurons by HIV-Tat PTD.
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Angiotensin AT1 receptor signalling pathways in neurons.
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Obligatory role of protein kinase Cbeta and MARCKS in vesicular trafficking in living neurons.
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Specific inhibition of N-methyl-D-aspartate receptor function in rat hippocampal neurons by L-phenylalanine at concentrations observed during phenylketonuria.
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Chronotropic effect of angiotensin II via type 2 receptors in rat brain neurons.
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Gene expression profiling of rat brain neurons reveals angiotensin II-induced regulation of calmodulin and synapsin I: possible role in neuromodulation.
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Novel role of macrophage migration inhibitory factor in angiotensin II regulation of neuromodulation in rat brain.
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Angiotensin II increases neuronal delayed rectifier K(+) current: role of 12-lipoxygenase metabolites of arachidonic acid.
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Angiotensin II-induced decrease in expression of inducible nitric oxide synthase in rat astroglial cultures: role of protein kinase C.
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Antagonism of the positive dromotropic effect of isoproterenol by adenosine: role of nitric oxide, cGMP-dependent cAMP-phosphodiesterase and protein kinase G.
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Expression of angiotensin AT(1) and AT(2) receptors in adult rat cardiomyocytes after myocardial infarction. A single-cell reverse transcriptase-polymerase chain reaction study.
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The angiotensin II type 2 receptor: an enigma with multiple variations.
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Angiotensin II decreases neuronal delayed rectifier potassium current: role of calcium/calmodulin-dependent protein kinase II.
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Angiotensin II type 1 receptor-mediated inhibition of K+ channel subunit kv2.2 in brain stem and hypothalamic neurons.
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Angiotensin II type 2 receptor-mediated apoptosis of cultured neurons from newborn rat brain.
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Angiotensin II in central nervous system physiology.
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Angiotensin II stimulates activation of Fos-regulating kinase and c-Jun NH2-terminal kinase in neuronal cultures from rat brain.
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Angiotensin receptors and norepinephrine neuromodulation: implications of functional coupling.
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Cytokine- and endotoxin-induced nitric oxide synthase in rat astroglial cultures: differential modulation by angiotensin II.
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Functional interactions between neuronal AT1 and AT2 receptors.
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Modulation of K+ and Ca2+ currents in cultured neurons by an angiotensin II type 1a receptor peptide.
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Regulation of alpha 2A-adrenergic receptor mRNA in rat astroglial cultures: role of cyclic AMP and protein kinase C.
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Angiotensin II regulation of intracellular calcium in astroglia cultured from rat hypothalamus and brainstem.
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Angiotensin II stimulates protein phosphatase 2A activity in cultured neuronal cells via type 2 receptors in a pertussis toxin sensitive fashion.
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Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptors.
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Angiotensin II decreases inducible nitric oxide synthase expression in rat astroglial cultures.
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Angiotensin II type 1 receptor-mediated stimulation of c-fos gene expression in astroglial cultures.
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Changes in skin angiotensin II receptors in rats during wound healing.
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Characterization of a polyclonal anti-peptide antibody to the angiotensin II type-1 (AT1) receptor.
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Angiotensin II receptor subtypes are coupled with distinct signal-transduction mechanisms in neurons and astrocytes from rat brain.
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Effect of exercise training on blood pressure in 70- to 79-yr-old men and women.
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Journal of applied physiology (Bethesda, Md. : 1985).
62(5):1845-51
[PMID] 2885302.
1987
Norepinephrine metabolism in neuronal cultures is increased by angiotensin II.
The American journal of physiology.
252(6 Pt 1):C650-6
[PMID] 3591934.
1987
Norepinephrine regulation of alpha-1 receptors and alpha-1-stimulated phosphoinositide hydrolysis in primary neuronal cultures.
The Journal of pharmacology and experimental therapeutics.
242(3):764-71
[PMID] 2821226.
1987
Presence of renin in primary neuronal and glial cells from rat brain.
Brain research.
437(2):205-13
[PMID] 3325128.
1987
Protein kinase C agonists increase the expression of angiotensin II receptors in neuronal cultures.
Journal of neurochemistry.
48(6):1954-61
[PMID] 3572405.
1986
Alpha 1-adrenergic receptor-mediated downregulation of angiotensin II receptors in neuronal cultures.
Journal of neurochemistry.
47(4):1117-26
[PMID] 3018160.
1986
Alpha 1-adrenergic receptors in neuronal cultures from rat brain: increased expression in the spontaneously hypertensive rat.
Journal of neurochemistry.
47(4):1190-8
[PMID] 3018164.
1986
Angiotensin II stimulates norepinephrine uptake in hypothalamus-brain stem neuronal cultures.
The American journal of physiology.
250(2 Pt 1):C236-44
[PMID] 3513605.
1986
Characteristics of the beta-adrenoreceptor from neuronal and glial cells in primary cultures of rat brain.
Journal of neurochemistry.
47(4):1318-26
[PMID] 2875131.
1986
Decreased alpha 1-adrenergic receptor-mediated inositide hydrolysis in neurons from hypertensive rat brain.
The American journal of physiology.
251(2 Pt 1):C230-7
[PMID] 2874741.
1986
Mineralocorticoids modulate central angiotensin II receptors in rats.
Brain research.
382(1):87-96
[PMID] 3768684.
1986
Sodium increases angiotensin II receptors in neuronal cultures from brains of normotensive and hypertensive rats.
Brain research.
370(2):265-72
[PMID] 3011198.
1985
Altered norepinephrine uptake in neuronal cultures from spontaneously hypertensive rat brain.
The American journal of physiology.
248(5 Pt 1):C488-97
[PMID] 3993770.
1985
Effects of catecholamines on lactic acid output during progressive working contractions.
Journal of applied physiology (Bethesda, Md. : 1985).
59(6):1809-14
[PMID] 4077789.
1985
Reduced dipsogenic responsiveness to intracerebroventricularly administered angiotensin II in estrogen-treated rats.
Brain research.
338(1):115-21
[PMID] 4027581.
1984
Angiotensin II in neuronal cultures from brains of normotensive and hypertensive rats.
The American journal of physiology.
247(1 Pt 1):C115-9
[PMID] 6742179.
1984
Catecholamine-angiotensin II receptor interaction in primary cultures of rat brain.
The American journal of physiology.
246(5 Pt 1):C502-9
[PMID] 6144276.
1984
Increased angiotensin II receptors in neuronal cultures from hypertensive rat brain.
The American journal of physiology.
247(5 Pt 1):C364-72
[PMID] 6093569.
1984
Plasma catecholamines and their effect on blood lactate and muscle lactate output.
Journal of applied physiology: respiratory, environmental and exercise physiology.
57(2):321-5
[PMID] 6469801.
1983
A comparison of the potencies of various dopamine receptor agonists in models for pre- and postsynaptic receptor activity.
Naunyn-Schmiedeberg's archives of pharmacology.
324(2):108-15
[PMID] 6646238.
1983
Angiotensin II stimulates changes in the norepinephrine content of primary cultures of rat brain.
Neuroscience letters.
36(3):305-9
[PMID] 6866336.
1983
Central injection of angiotensin II alters catecholamine activity in rat brain.
The American journal of physiology.
244(2):R257-63
[PMID] 6130707.
1983
Rat brain cells in primary culture: visualization and measurement of catecholamines.
Brain research.
264(2):267-75
[PMID] 6850296.
1982
Central pressor action of neurotensin in conscious rats.
Hypertension (Dallas, Tex. : 1979).
4(6):888-93
[PMID] 6815078.
1981
Behavioural and neurochemical studies on apomorphine-induced hypomotility in mice.
Neuropharmacology.
20(12A):1203-8
[PMID] 7322296.
1981
Effects of specific dopamine lesions and dopamine receptor sensitivity on angiotensin II- and carbachol-induced thirst in rats.
Psychopharmacology.
73(2):180-3
[PMID] 6785812.
1981
Involvement of both dopaminergic and alpha-adrenergic receptors in the hypomotility induced by dibenzoyl-6,7-ADTN.
European journal of pharmacology.
70(4):541-50
[PMID] 6113149.
1981
Neurochemical and behavioural profiles of five dopamine analogues.
Naunyn-Schmiedeberg's archives of pharmacology.
316(4):304-10
[PMID] 7196506.
1979
The effect of neuroleptic drugs on drinking induced by central administration of angiotensin or carbachol.
Psychopharmacology.
60(3):291-4
[PMID] 35805.
1978
The effect of neuroleptic drugs on angiotensin- and carbachol-induced drinking [proceedings].
The Journal of physiology.
284:62P-63P
[PMID] 32390.
Grants
Mar 2023
– Sep 2023
Angiotensin-sensitive neurons in the nucleus of the solitary tract mediate social stress induced hypertension
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Dec 2017
– Nov 2022
Neurons expressing angiotensin type 2 receptors in the NTS as an access point for cardiovascular control.
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Dec 2014
– Aug 2016
Novel role of central AT2R in blood pressure regulation
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Apr 2013
– Dec 2016
FAPESP Collaborative Research Matching Fund
Role: Project Manager
Funding: UF DIV OF SPONSORED RES MATCHING FUNDS
May 2011
– Mar 2016
MIF: A Novel CNS Regulator Of Cardiovascular Function
Role: Principal Investigator
Funding: NATL INST OF HLTH NHLBI
Jul 2007
– Aug 2016
Clinical and Translational Science Institute
Role: Project Manager
Funding: UF RESEARCH FOU
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Phones:
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