Identification of Novel Cross-Talk Between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure.
Date and time: August 24, 2021. From: 12:00 PM – 1:00 PM ET
Join this interactive session as Khalid Elsaafien and Eric Krause discuss their paper, “Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure” with JNeurosci Editor-in-Chief Marina Picciotto. Attendees can submit questions at registration and live during the webinar.
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Below is the significance statement of Identification of Novel Cross-Talk between the Neuroendocrine and Autonomic Stress Axes Controlling Blood Pressure, published on May 26, 2021, in JNeurosci and authored by Khalid Elsaafien, Matthew K. Kirchner, Mazher Mohammed, Sophia A. Eikenberry, Chloe West, Karen A. Scott, Annette D. de Kloet, Javier E. Stern, and Eric G. Krause.
The survival of an organism is dependent on meeting the energetic demands imposed by stressors. This critical function is accomplished by the CNS’s ability to orchestrate simultaneous activities of neurosecretory and autonomic axes. Here, we unveil a novel signaling mechanism within the paraventricular nucleus of the hypothalamus that links excitation of neurons producing corticotropin-releasing-hormone with excitation of neurons controlling sympathetic nervous system activity and blood pressure. The implication is that chronic stress exposure may promote cardiometabolic disease by dysregulating the interneuronal cross-talk revealed by our experiments.
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